Differential expression of c-fos and hsp72 mRNA in focal cerebral ischemia of mice

R. Hata, G. Mies, C. Wiessner, K. A. Hossmann

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


THE heterogeneity of c-fos and hsp72 mRNA expression during focal ischemia was studied in mice by combining in situ hybridization with metabolic imaging. Focal ischemia was produced by middle cerebral artery occlusion for 3 h. The infarct core and the penumbra were differentiated by regional ATP and cerebral protein synthesis (CPS) imaging. hsp72 mRNA expression was restricted to the ischemic penumbra, as defined by the dissociation between preserved ATP and suppressed CPS. c-fos mRNA was expressed not only in the penumbra but also in the peri-ischemic normal brain tissue in which both ATP and CPS were preserved. These data demonstrate a highly selective differential expression of immediate-early and stress- related genes in the peri-infarct surrounding which is explained by different mechanisms of gene induction.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
Issue number1
Publication statusPublished - 05-01-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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