Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity

Kayou Narita, Naoki Koide, Akiko Morikawa, Yutaka Kato, Tsuyoshi Sugiyama, Tomoaki Yoshida, Takashi Yokochi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalJapanese Journal of Medical Science and Biology
Volume50
Issue number6
DOIs
Publication statusPublished - 12-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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