Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity

Kayou Narita; Naoki Koide; Akiko Morikawa; Yutaka Kato; Tsuyoshi Sugiyama; Tomoaki Yoshida; Takashi Yokochi

doi:10.7883/yoken1952.50.233

Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity

Kayou Narita
, Naoki Koide
, Akiko Morikawa
, Yutaka Kato
, Tsuyoshi Sugiyama
, Tomoaki Yoshida
, Takashi Yokochi

Medical Biology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.

Original language	English
Pages (from-to)	233-239
Number of pages	7
Journal	Japanese Journal of Medical Science and Biology
Volume	50
Issue number	6
DOIs	https://doi.org/10.7883/yoken1952.50.233
Publication status	Published - 12-1997

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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title = "Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity",

abstract = "The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.",

author = "Kayou Narita and Naoki Koide and Akiko Morikawa and Yutaka Kato and Tsuyoshi Sugiyama and Tomoaki Yoshida and Takashi Yokochi",

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AU - Narita, Kayou

AU - Koide, Naoki

AU - Morikawa, Akiko

AU - Kato, Yutaka

AU - Sugiyama, Tsuyoshi

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

PY - 1997/12

Y1 - 1997/12

N2 - The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.

AB - The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.

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JO - Japanese Journal of Medical Science and Biology

JF - Japanese Journal of Medical Science and Biology

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Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity

Abstract

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