TY - JOUR
T1 - Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy
AU - Mizokami, Masashi
AU - Lau, Johnson Y.N.
AU - Suzuki, Kaoru
AU - Nakano, Tatsunori
AU - Gojobori, Takashi
N1 - Funding Information:
of Japan. JYNL was supported in part by the DSR-D-I 5, DSR-RDA-I-15 grants from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; the American Liver Association Hans Popper Liver Scholar Award; and the Glaxo Institute of Digestive Health Clinical Investigator Award.
Funding Information:
MM was supported by grants from the Japanese Ministry of Welfare and Viral Hepatitis Research Foundation
PY - 1994
Y1 - 1994
N2 - The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.
AB - The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.
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U2 - 10.1016/S0168-8278(94)80254-8
DO - 10.1016/S0168-8278(94)80254-8
M3 - Article
C2 - 7890907
AN - SCOPUS:0028019391
VL - 21
SP - 884
EP - 886
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 5
ER -