Differential TH1/TH2 chemokine expression in interstitial pneumonia

Toyohiro Honda, Kazuyoshi Imaizumi, Toyoharu Yokoi, Naozumi Hashimoto, Izumi Hashimoto, Tsutomu Kawabe, Masaki Matsuo, Shingo Iwano, Kaoru Shimokata, Yoshinori Hasegawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: T-helper (Th)-2 background in the lungs may favor the development of pulmonary fibrosis. We hypothesized that usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), major pathologic patterns of chronic interstitial pneumonia, would have different expression profiles of TH1 and TH2 chemokines. Methods: Total RNA was isolated from lung tissues obtained by surgical biopsy (18 cases of UIP and 29 cases of NSIP). The expression of ligands for CXCR3 [TH1 cells chemoattractant: monokine induced by interferon (IFN)-γ (MIG), IFN-γ-inducible protein of 10 kD, and IFN-inducible T cell α chemoattractant] and ligands for CCR4 [TH2 cells chemoattractant: thymus- and activation-regulated chemokine and macrophage-derived chemokine (MDC)] were analyzed by real-time reverse transcriptase polymerase chain reaction. Results: MIG and IFNγ-inducible protein of 10 kD expression were significantly higher in NSIP compared with UIP. MDC expression was increased in UIP compared with NSIP, although the difference was not significant. MIG/MDC is significantly elevated in NSIP but not UIP. Interestingly, MIG/MDC was significantly higher in NSIP group 3 (NSIP with extensive fibrosis) compared with UIP. Conclusions: These results may indicate that these 2 diseases have a different pathophysiology. MIG/MDC may be a useful marker to distinguish these 2 diseases.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalAmerican Journal of the Medical Sciences
Volume339
Issue number1
DOIs
Publication statusPublished - 01-2010

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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