Diffuse Infiltrating T-cell Lymphoma of the Colon Associated with Polyclonal Hypergammaglobulinemia and Hepatocellular Carcinoma: Report of a Case

Tadanori Nagai, Rhyuzou Koyama, Yutaka Sasagawa, Shuji Matsumoto, Yohoshiro Niitsu, Shin Ichi Takayama, Toshiya Murakami, Akihiro Matsuura

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A 55-year-old man with a chief complaint of melena had diffusely infiltrated lymphoma from the rectum to the sigmoid colon and polyclonal hypergammaglobulinemia. Biopsy specimen obtained from the rectum revealed diffuse medium-sized lymphoma cell with plasmocytosis. Histochemical analysis with monoclonal antibodies indicated that the origin of the tumor cell to be T-lymphocyte. Chemotherapy with cyclophosphamide, vincristine and prednisolone (VEP regimen) was effective for mucosal bleeding of the colonic lesion and reduction of polyclonal hypergammaglobulinemia. Five yrs later he showed recurrence of the disease and elevation of serum alphafetoprotein, and died of pulmonary infections. Autopsy finding confirmed the diagnosis of malignant lymphoma of the colon and disclosed the association of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalJapanese Journal of Medicine
Issue number1
Publication statusPublished - 01-01-1991


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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