TY - JOUR
T1 - Diffusion-weighted imaging vs STIR turbo SE imaging
T2 - Capability for quantitative differentiation of small-cell lung cancer from non-small-cell lung cancer
AU - Koyama, H.
AU - Ohno, Y.
AU - Nishio, M.
AU - Takenaka, D.
AU - Yoshikawa, T.
AU - Matsumoto, S.
AU - Seki, S.
AU - Maniwa, Y.
AU - Ito, T.
AU - Nishimura, Y.
AU - Sugimura, K.
N1 - Publisher Copyright:
© 2014 The Authors.
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Objective: To compare the capability of differentiation of small-cell lung cancer (SCLC) from non-SCLC (NSCLC) between diffusion-weighted imaging (DWI) and short tau inversion recovery (STIR) turbo spin-echo imaging.Methods: The institutional review board of Kobe University Hospital, Kobe, Japan, approved this study, and written informed consent was obtained from each patient. 49 patients with NSCLC (30 males and 19 females; mean age, 66.8 years) and 7 patients with SCLC (5 males and 2 females; mean age, 68.6 years) enrolled and underwent DWI and STIR. To quantitatively differentiate SCLC from NSCLC, apparent diffusion coefficient (ADC) values on DWI and contrast ratios (CRs) between cancer and muscle on STIR were evaluated. ADC values and CRs were then compared between the two cell types by Mann-Whitney's U-tests, and the diagnostic performances were compared by McNemar's test.Results: There were significant differences of mean ADC values (p<0.001) and mean CRs (p=0.003). With adopted threshold values, the specificity (85.7%) and accuracy (85.7%) of DWI were higher than those of STIR (specificity, 63.3%; p=0.001 and accuracy, 66.1%; p=0.001). In addition, the accuracy of combination of bothindexes (94.6%;p=0.04) couldsignificantlyimprove as compared with DWI alone.Conclusion: DWI is more useful for the differentiation of SCLC from NSCLC than STIR, and their combination can significantly improve the accuracy in this setting.Advances in knowledge: Pulmonary MRI, including DWI and STIR, had a potential of the suggestion of the possibility as SCLC.
AB - Objective: To compare the capability of differentiation of small-cell lung cancer (SCLC) from non-SCLC (NSCLC) between diffusion-weighted imaging (DWI) and short tau inversion recovery (STIR) turbo spin-echo imaging.Methods: The institutional review board of Kobe University Hospital, Kobe, Japan, approved this study, and written informed consent was obtained from each patient. 49 patients with NSCLC (30 males and 19 females; mean age, 66.8 years) and 7 patients with SCLC (5 males and 2 females; mean age, 68.6 years) enrolled and underwent DWI and STIR. To quantitatively differentiate SCLC from NSCLC, apparent diffusion coefficient (ADC) values on DWI and contrast ratios (CRs) between cancer and muscle on STIR were evaluated. ADC values and CRs were then compared between the two cell types by Mann-Whitney's U-tests, and the diagnostic performances were compared by McNemar's test.Results: There were significant differences of mean ADC values (p<0.001) and mean CRs (p=0.003). With adopted threshold values, the specificity (85.7%) and accuracy (85.7%) of DWI were higher than those of STIR (specificity, 63.3%; p=0.001 and accuracy, 66.1%; p=0.001). In addition, the accuracy of combination of bothindexes (94.6%;p=0.04) couldsignificantlyimprove as compared with DWI alone.Conclusion: DWI is more useful for the differentiation of SCLC from NSCLC than STIR, and their combination can significantly improve the accuracy in this setting.Advances in knowledge: Pulmonary MRI, including DWI and STIR, had a potential of the suggestion of the possibility as SCLC.
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U2 - 10.1259/bjr.20130307
DO - 10.1259/bjr.20130307
M3 - Article
C2 - 24786147
AN - SCOPUS:84907485571
SN - 0007-1285
VL - 87
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1038
M1 - 20130307
ER -
