TY - JOUR
T1 - Diffusion-weighted MR imaging vs. Multi-detector row CT
T2 - Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors
AU - Seki, Shinichiro
AU - Koyama, Hisanobu
AU - Ohno, Yoshiharu
AU - Nishio, Mizuho
AU - Takenaka, Daisuke
AU - Maniwa, Yoshimasa
AU - Itoh, Tomoo
AU - Nishimura, Yoshihiro
AU - Sugimura, Kazuro
N1 - Funding Information:
This prospective study was approved by the Institutional Review Board of (*Anonymized*) and technically and financially supported by (*Anonymized*). Written informed consent was obtained from all subjects prior to enrolment in the study.
PY - 2014/5
Y1 - 2014/5
N2 - Purpose To evaluate and compare the capability of diffusion-weighted MR imaging (DWI) and CT for assessment of management needs for anterior mediastinal solitary tumors. Materials and methods Thirty-five patients with pathologically confirmed anterior mediastinal tumors were enrolled. The tumors were divided into two groups according to need for management: tumors not needing further intervention or treatment (group A; thymoma type A, AB and B1) and tumors needing further intervention and treatment (group B; other thymoma types and malignancies). The apparent diffusion coefficient (ADC) of each tumor was measured, and probabilities of malignancy and need for further intervention and treatment were visually assessed on CT. The differences in ADCs between group A and B and between malignancies and thymomas in group B were evaluated with the Mann-Whitney's U-test. Feasible threshold values for differentiation of group B from group A and distinguishing malignancies from thymomas assessed as group B were determined by the ROC-based positive test, and McNemar's test was used for comparing diagnostic capabilities of DWI with those of CT. Results ADCs for the two groups were significantly different (p < 0.001). Application of the threshold value for differentiation of group B from A showed no significant difference (p > 0.05). Application of the feasible threshold value for distinguishing malignant from thymomas assessed as group B showed that specificity (76.9%) and accuracy (85.2%) of DWI were significantly better than those of visual score (p < 0.05). Conclusion DWI has useful potential for the assessment of management needs for anterior mediastinum solitary tumors as well as CT.
AB - Purpose To evaluate and compare the capability of diffusion-weighted MR imaging (DWI) and CT for assessment of management needs for anterior mediastinal solitary tumors. Materials and methods Thirty-five patients with pathologically confirmed anterior mediastinal tumors were enrolled. The tumors were divided into two groups according to need for management: tumors not needing further intervention or treatment (group A; thymoma type A, AB and B1) and tumors needing further intervention and treatment (group B; other thymoma types and malignancies). The apparent diffusion coefficient (ADC) of each tumor was measured, and probabilities of malignancy and need for further intervention and treatment were visually assessed on CT. The differences in ADCs between group A and B and between malignancies and thymomas in group B were evaluated with the Mann-Whitney's U-test. Feasible threshold values for differentiation of group B from group A and distinguishing malignancies from thymomas assessed as group B were determined by the ROC-based positive test, and McNemar's test was used for comparing diagnostic capabilities of DWI with those of CT. Results ADCs for the two groups were significantly different (p < 0.001). Application of the threshold value for differentiation of group B from A showed no significant difference (p > 0.05). Application of the feasible threshold value for distinguishing malignant from thymomas assessed as group B showed that specificity (76.9%) and accuracy (85.2%) of DWI were significantly better than those of visual score (p < 0.05). Conclusion DWI has useful potential for the assessment of management needs for anterior mediastinum solitary tumors as well as CT.
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U2 - 10.1016/j.ejrad.2014.01.005
DO - 10.1016/j.ejrad.2014.01.005
M3 - Article
C2 - 24636535
AN - SCOPUS:84897439974
VL - 83
SP - 835
EP - 842
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 5
ER -