Diisopropylfluorophosphate and GABA synaptic function

Effect on levels, enzymes, release and uptake in the rat striatum

S. P. Sivam, Toshitaka Nabeshima, D. K. Lim, B. Hoskins, I. K. Ho

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The present study revealed that diisopropylfluorophosphate increased the GABA and glutamate levels, decreased the uptake of GABA, decreased the spontaneous release of GABA and did not exhibit its effects on the metabolic enzymes of GABA, glutamic acid decarboxylase and GABA-transaminase. These results, together with our previous findings that the postsynaptic GABA receptor population is increased by DFP treatment, indicate that GABA transmission is affected by DFP. An overall enhancement of GABA function appears to be involved in DFP poisoning; it is suggested that this may be a compensatory mechanism to counteract the cholinergic hyperactivity.

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume42
Issue number1
Publication statusPublished - 01-12-1983

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Isoflurophate
gamma-Aminobutyric Acid
Rats
Enzymes
4-Aminobutyrate Transaminase
GABA Receptors
Glutamate Decarboxylase
Poisoning
Cholinergic Agents
Glutamic Acid
Population

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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Diisopropylfluorophosphate and GABA synaptic function : Effect on levels, enzymes, release and uptake in the rat striatum. / Sivam, S. P.; Nabeshima, Toshitaka; Lim, D. K.; Hoskins, B.; Ho, I. K.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 42, No. 1, 01.12.1983, p. 51-60.

Research output: Contribution to journalArticle

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