Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade

Ei Ei Khin, Fumitaka Kikkawa, Kazuhiko Ino, Hiroaki Kajiyama, Takahiro Suzuki, Kiyosumi Shibata, Koji Tamakoshi, Tetsuro Nagasaka, Shigehiko Mizutani

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

OBJECTIVES: Dipeptidyl peptidase IV (DPPIV)/CD26 is a ceil surface aminopeptidase. This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades. STUDY DESIGN: Immunohistochemical analysis was performed by using DPPIV and regulated on activation, normal T-cell expressed and secreted (RANTES) specific monoclonal antibodies. Cell proliferation was evaluated by bromodeoxyuridine (BrdU) uptake assay. RESULTS: Immunohistochemical analyses showed that DPPIV was strongly or moderately stained in glandular cells of the normal secretory phase. In endometrial adenocarcinoma, the DPPIV expression decreased with advancing grade (P < .01). Furthermore, RANTES, one of the possible DPPIV substrates, was highly expressed in all grades of endometrial adenocarcinoma cells. The addition of RANTES to endometrial adenocarcinoma ceils increased proliferation in a concentration-dependent manner. CONCLUSION: DPPIV is expressed in normal endometrial glandular cells, but its expression in endometrial adenocarcinoma is down-regulated with increasing grade. Our data also suggest a regulatory role of this ectoenzyme in neoplastic transformation and progression of endometrial adenocarcinomas possibly by degrading certain bioactive peptides such as RANTES.

Original languageEnglish
Pages (from-to)670-676
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume188
Issue number3
DOIs
Publication statusPublished - 01-03-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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