DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

Suhail Asrar, Keiko Kaneko, Keizo Takao, Jaina Negandhi, Makoto Matsui, Koji Shibasaki, Tsuyoshi Miyakawa, Robert V. Harrison, Zhengping Jia, Michael W. Salter, Makoto Tominaga, Tomoko Fukumi-Tominaga

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

Original languageEnglish
Article number39
JournalMolecular brain
Issue number1
Publication statusPublished - 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze'. Together they form a unique fingerprint.

Cite this