DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

Suhail Asrar; Keiko Kaneko; Keizo Takao; Jaina Negandhi; Makoto Matsui; Koji Shibasaki; Tsuyoshi Miyakawa; Robert V. Harrison; Zhengping Jia; Michael W. Salter; Makoto Tominaga; Tomoko Fukumi-Tominaga

doi:10.1186/1756-6606-4-39

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

Suhail Asrar, Keiko Kaneko, Keizo Takao, Jaina Negandhi, Makoto Matsui, Koji Shibasaki, Tsuyoshi Miyakawa, Robert V. Harrison, Zhengping Jia, Michael W. Salter, Makoto Tominaga, Tomoko Fukumi-Tominaga

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

Original language	English
Article number	39
Journal	Molecular brain
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/1756-6606-4-39
Publication status	Published - 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1186/1756-6606-4-39

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@article{0de4add329644d3bb931cddcd9b42656,

title = "DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze",

abstract = "Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.",

author = "Suhail Asrar and Keiko Kaneko and Keizo Takao and Jaina Negandhi and Makoto Matsui and Koji Shibasaki and Tsuyoshi Miyakawa and Harrison, {Robert V.} and Zhengping Jia and Salter, {Michael W.} and Makoto Tominaga and Tomoko Fukumi-Tominaga",

note = "Funding Information: This work was supported by grants to TF-T and MT from the Ministry of Education, Culture, Sports, Science. We thank Dr. Yugo Fukazawa (National Institute for Physiological Science, Japan) for his assistance for Golgi-staining.",

year = "2011",

doi = "10.1186/1756-6606-4-39",

language = "English",

volume = "4",

journal = "Molecular brain",

issn = "1756-6606",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

AU - Asrar, Suhail

AU - Kaneko, Keiko

AU - Takao, Keizo

AU - Negandhi, Jaina

AU - Matsui, Makoto

AU - Shibasaki, Koji

AU - Miyakawa, Tsuyoshi

AU - Harrison, Robert V.

AU - Jia, Zhengping

AU - Salter, Michael W.

AU - Tominaga, Makoto

AU - Fukumi-Tominaga, Tomoko

N1 - Funding Information: This work was supported by grants to TF-T and MT from the Ministry of Education, Culture, Sports, Science. We thank Dr. Yugo Fukazawa (National Institute for Physiological Science, Japan) for his assistance for Golgi-staining.

PY - 2011

Y1 - 2011

N2 - Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

AB - Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

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VL - 4

JO - Molecular brain

JF - Molecular brain

IS - 1

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ER -

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

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