DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

Suhail Asrar, Keiko Kaneko, Keizo Takao, Jaina Negandhi, Makoto Matsui, Koji Shibasaki, Tsuyoshi Miyakawa, Robert V. Harrison, Zhengping Jia, Michael W. Salter, Makoto Tominaga, Tomoko Fukumi-Tominaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

Original languageEnglish
Article number39
JournalMolecular Brain
Volume4
Issue number1
DOIs
Publication statusPublished - 24-10-2011
Externally publishedYes

Fingerprint

Protein Deficiency
Proteins
Long-Term Potentiation
Spine
Wiskott-Aldrich Syndrome Protein
Actin Cytoskeleton
Synaptic Transmission
Microtubules
Synapses
Actins
Head
Neurons

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Asrar, S., Kaneko, K., Takao, K., Negandhi, J., Matsui, M., Shibasaki, K., ... Fukumi-Tominaga, T. (2011). DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze. Molecular Brain, 4(1), [39]. https://doi.org/10.1186/1756-6606-4-39
Asrar, Suhail ; Kaneko, Keiko ; Takao, Keizo ; Negandhi, Jaina ; Matsui, Makoto ; Shibasaki, Koji ; Miyakawa, Tsuyoshi ; Harrison, Robert V. ; Jia, Zhengping ; Salter, Michael W. ; Tominaga, Makoto ; Fukumi-Tominaga, Tomoko. / DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze. In: Molecular Brain. 2011 ; Vol. 4, No. 1.
@article{0de4add329644d3bb931cddcd9b42656,
title = "DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze",
abstract = "Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.",
author = "Suhail Asrar and Keiko Kaneko and Keizo Takao and Jaina Negandhi and Makoto Matsui and Koji Shibasaki and Tsuyoshi Miyakawa and Harrison, {Robert V.} and Zhengping Jia and Salter, {Michael W.} and Makoto Tominaga and Tomoko Fukumi-Tominaga",
year = "2011",
month = "10",
day = "24",
doi = "10.1186/1756-6606-4-39",
language = "English",
volume = "4",
journal = "Molecular Brain",
issn = "1756-6606",
publisher = "BioMed Central",
number = "1",

}

Asrar, S, Kaneko, K, Takao, K, Negandhi, J, Matsui, M, Shibasaki, K, Miyakawa, T, Harrison, RV, Jia, Z, Salter, MW, Tominaga, M & Fukumi-Tominaga, T 2011, 'DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze', Molecular Brain, vol. 4, no. 1, 39. https://doi.org/10.1186/1756-6606-4-39

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze. / Asrar, Suhail; Kaneko, Keiko; Takao, Keizo; Negandhi, Jaina; Matsui, Makoto; Shibasaki, Koji; Miyakawa, Tsuyoshi; Harrison, Robert V.; Jia, Zhengping; Salter, Michael W.; Tominaga, Makoto; Fukumi-Tominaga, Tomoko.

In: Molecular Brain, Vol. 4, No. 1, 39, 24.10.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

AU - Asrar, Suhail

AU - Kaneko, Keiko

AU - Takao, Keizo

AU - Negandhi, Jaina

AU - Matsui, Makoto

AU - Shibasaki, Koji

AU - Miyakawa, Tsuyoshi

AU - Harrison, Robert V.

AU - Jia, Zhengping

AU - Salter, Michael W.

AU - Tominaga, Makoto

AU - Fukumi-Tominaga, Tomoko

PY - 2011/10/24

Y1 - 2011/10/24

N2 - Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

AB - Background: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. Results: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. Conclusions: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

UR - http://www.scopus.com/inward/record.url?scp=80054729392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054729392&partnerID=8YFLogxK

U2 - 10.1186/1756-6606-4-39

DO - 10.1186/1756-6606-4-39

M3 - Article

C2 - 22018352

AN - SCOPUS:80054729392

VL - 4

JO - Molecular Brain

JF - Molecular Brain

SN - 1756-6606

IS - 1

M1 - 39

ER -

Asrar S, Kaneko K, Takao K, Negandhi J, Matsui M, Shibasaki K et al. DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze. Molecular Brain. 2011 Oct 24;4(1). 39. https://doi.org/10.1186/1756-6606-4-39