Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells

Osamu Kamihira, Izumi Nakashima, Tadao Hasegawa, Ko ichi Ando, Ken ichi Isobe, Fumihiko Nagase, Yoshinori Hasegawa, Tomoaki Yoshida, Kohei Kawashima, Tetsuya Yoshida, Takashi Yokochi

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Abstract

Syngeneic spleen cells (SPC) sensitized in vitro with noninfectious NVJ were shown to effectively stimulate mice to generate the HVJ-specific cell-mediated immunity for second set rejection (SSR) of virus-infected syngeneic leukemia cells. As few as 104 live but not disrupted SPC either infected with a temperature-sensitive mutant of HVJ (HVJts) or sensitized passively with ultraviolet (UV)-inactivated HVJts were active as immunogen. Syngeneic SPC as the carrier of virus could be replaced by allogeneic SPC or L cells, a fibroblast cell line, without reduction of the immunogenicity. Further study demonstrated that a special density of antigen on the surface of HVJts-sensitized SPC is required for high immunogenicity. It was suggested that live cells appropriately sensitized with noninfectious virus would serve as an excellent vaccine for virus-specific cell-mediated immunity.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalImmunology Letters
Volume11
Issue number2
DOIs
Publication statusPublished - 1985

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Kamihira, O., Nakashima, I., Hasegawa, T., Ando, K. I., Isobe, K. I., Nagase, F., Hasegawa, Y., Yoshida, T., Kawashima, K., Yoshida, T., & Yokochi, T. (1985). Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells. Immunology Letters, 11(2), 75-81. https://doi.org/10.1016/0165-2478(85)90146-4