Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells

Osamu Kamihira; Izumi Nakashima; Tadao Hasegawa; Ko ichi Ando; Ken ichi Isobe; Fumihiko Nagase; Yoshinori Hasegawa; Tomoaki Yoshida; Kohei Kawashima; Tetsuya Yoshida; Takashi Yokochi

doi:10.1016/0165-2478(85)90146-4

Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells

Osamu Kamihira, Izumi Nakashima, Tadao Hasegawa, Ko ichi Ando, Ken ichi Isobe, Fumihiko Nagase, Yoshinori Hasegawa, Tomoaki Yoshida, Kohei Kawashima, Tetsuya Yoshida, Takashi Yokochi

Medical Biology

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Abstract

Syngeneic spleen cells (SPC) sensitized in vitro with noninfectious NVJ were shown to effectively stimulate mice to generate the HVJ-specific cell-mediated immunity for second set rejection (SSR) of virus-infected syngeneic leukemia cells. As few as 10⁴ live but not disrupted SPC either infected with a temperature-sensitive mutant of HVJ (HVJ_ts) or sensitized passively with ultraviolet (UV)-inactivated HVJ_ts were active as immunogen. Syngeneic SPC as the carrier of virus could be replaced by allogeneic SPC or L cells, a fibroblast cell line, without reduction of the immunogenicity. Further study demonstrated that a special density of antigen on the surface of HVJ_ts-sensitized SPC is required for high immunogenicity. It was suggested that live cells appropriately sensitized with noninfectious virus would serve as an excellent vaccine for virus-specific cell-mediated immunity.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Immunology Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0165-2478(85)90146-4
Publication status	Published - 1985

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-2478(85)90146-4

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Kamihira, O., Nakashima, I., Hasegawa, T., Ando, K. I., Isobe, K. I., Nagase, F., Hasegawa, Y., Yoshida, T., Kawashima, K., Yoshida, T., & Yokochi, T. (1985). Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells. Immunology Letters, 11(2), 75-81. https://doi.org/10.1016/0165-2478(85)90146-4

@article{1da228f14f0745b1819e31035d54156c,

title = "Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells",

abstract = "Syngeneic spleen cells (SPC) sensitized in vitro with noninfectious NVJ were shown to effectively stimulate mice to generate the HVJ-specific cell-mediated immunity for second set rejection (SSR) of virus-infected syngeneic leukemia cells. As few as 104 live but not disrupted SPC either infected with a temperature-sensitive mutant of HVJ (HVJts) or sensitized passively with ultraviolet (UV)-inactivated HVJts were active as immunogen. Syngeneic SPC as the carrier of virus could be replaced by allogeneic SPC or L cells, a fibroblast cell line, without reduction of the immunogenicity. Further study demonstrated that a special density of antigen on the surface of HVJts-sensitized SPC is required for high immunogenicity. It was suggested that live cells appropriately sensitized with noninfectious virus would serve as an excellent vaccine for virus-specific cell-mediated immunity.",

author = "Osamu Kamihira and Izumi Nakashima and Tadao Hasegawa and Ando, \{Ko ichi\} and Isobe, \{Ken ichi\} and Fumihiko Nagase and Yoshinori Hasegawa and Tomoaki Yoshida and Kohei Kawashima and Tetsuya Yoshida and Takashi Yokochi",

note = "Funding Information: This study was supported in part by a Grant-in-aid for Cancer Research from the Ministry of Education, Science and Culture of Japan, and by The Ishida Foundation. The authors thank Dr. Y. Nagai, Research Institute of Disease Mechanism and Control, for discussion.",

year = "1985",

doi = "10.1016/0165-2478(85)90146-4",

language = "English",

volume = "11",

pages = "75--81",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

number = "2",

}

Kamihira, O, Nakashima, I, Hasegawa, T, Ando, KI, Isobe, KI, Nagase, F, Hasegawa, Y, Yoshida, T, Kawashima, K, Yoshida, T & Yokochi, T 1985, 'Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells', Immunology Letters, vol. 11, no. 2, pp. 75-81. https://doi.org/10.1016/0165-2478(85)90146-4

Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells. / Kamihira, Osamu; Nakashima, Izumi; Hasegawa, Tadao et al.
In: Immunology Letters, Vol. 11, No. 2, 1985, p. 75-81.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells

AU - Kamihira, Osamu

AU - Nakashima, Izumi

AU - Hasegawa, Tadao

AU - Ando, Ko ichi

AU - Isobe, Ken ichi

AU - Nagase, Fumihiko

AU - Hasegawa, Yoshinori

AU - Yoshida, Tomoaki

AU - Kawashima, Kohei

AU - Yoshida, Tetsuya

AU - Yokochi, Takashi

N1 - Funding Information: This study was supported in part by a Grant-in-aid for Cancer Research from the Ministry of Education, Science and Culture of Japan, and by The Ishida Foundation. The authors thank Dr. Y. Nagai, Research Institute of Disease Mechanism and Control, for discussion.

PY - 1985

Y1 - 1985

N2 - Syngeneic spleen cells (SPC) sensitized in vitro with noninfectious NVJ were shown to effectively stimulate mice to generate the HVJ-specific cell-mediated immunity for second set rejection (SSR) of virus-infected syngeneic leukemia cells. As few as 104 live but not disrupted SPC either infected with a temperature-sensitive mutant of HVJ (HVJts) or sensitized passively with ultraviolet (UV)-inactivated HVJts were active as immunogen. Syngeneic SPC as the carrier of virus could be replaced by allogeneic SPC or L cells, a fibroblast cell line, without reduction of the immunogenicity. Further study demonstrated that a special density of antigen on the surface of HVJts-sensitized SPC is required for high immunogenicity. It was suggested that live cells appropriately sensitized with noninfectious virus would serve as an excellent vaccine for virus-specific cell-mediated immunity.

AB - Syngeneic spleen cells (SPC) sensitized in vitro with noninfectious NVJ were shown to effectively stimulate mice to generate the HVJ-specific cell-mediated immunity for second set rejection (SSR) of virus-infected syngeneic leukemia cells. As few as 104 live but not disrupted SPC either infected with a temperature-sensitive mutant of HVJ (HVJts) or sensitized passively with ultraviolet (UV)-inactivated HVJts were active as immunogen. Syngeneic SPC as the carrier of virus could be replaced by allogeneic SPC or L cells, a fibroblast cell line, without reduction of the immunogenicity. Further study demonstrated that a special density of antigen on the surface of HVJts-sensitized SPC is required for high immunogenicity. It was suggested that live cells appropriately sensitized with noninfectious virus would serve as an excellent vaccine for virus-specific cell-mediated immunity.

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U2 - 10.1016/0165-2478(85)90146-4

DO - 10.1016/0165-2478(85)90146-4

M3 - Article

C2 - 3002972

AN - SCOPUS:0022358855

SN - 0165-2478

VL - 11

SP - 75

EP - 81

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells

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