Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients

Takashi Nihashi, Hiroshi Yatsuya, Kazumasa Hayasaka, Rikio Kato, Shoji Kawatsu, Yutaka Arahata, Katsushige Iwai, Akinori Takeda, Yukihiko Washimi, Kumiko Yoshimura, Kanako Mizuno, Takashi Kato, Shinji Naganawa, Kengo Ito

Research output: Contribution to journalArticle

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Abstract

Purpose. The purpose of this study was to evaluate and compare the diagnostic ability of 2-[ 18 F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p- 123 I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). Materials and methods. FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. Conclusion. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume25
Issue number6
DOIs
Publication statusPublished - 01-07-2007
Externally publishedYes

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Single-Photon Emission-Computed Tomography
glucose
Positron-Emission Tomography
positrons
Alzheimer Disease
tomography
Glucose
photons
Gyrus Cinguli
ROC Curve
Cerebrovascular Circulation
Parietal Lobe
Aptitude
hypometabolism
Regional Blood Flow
Area Under Curve
curves
receivers
physicians
Physicians

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Nihashi, Takashi ; Yatsuya, Hiroshi ; Hayasaka, Kazumasa ; Kato, Rikio ; Kawatsu, Shoji ; Arahata, Yutaka ; Iwai, Katsushige ; Takeda, Akinori ; Washimi, Yukihiko ; Yoshimura, Kumiko ; Mizuno, Kanako ; Kato, Takashi ; Naganawa, Shinji ; Ito, Kengo. / Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. In: Radiation Medicine - Medical Imaging and Radiation Oncology. 2007 ; Vol. 25, No. 6. pp. 255-262.
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abstract = "Purpose. The purpose of this study was to evaluate and compare the diagnostic ability of 2-[ 18 F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p- 123 I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). Materials and methods. FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. Conclusion. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86{\%}, and 97{\%} for FDG-PET and 70{\%} and 100{\%} for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).",
author = "Takashi Nihashi and Hiroshi Yatsuya and Kazumasa Hayasaka and Rikio Kato and Shoji Kawatsu and Yutaka Arahata and Katsushige Iwai and Akinori Takeda and Yukihiko Washimi and Kumiko Yoshimura and Kanako Mizuno and Takashi Kato and Shinji Naganawa and Kengo Ito",
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Nihashi, T, Yatsuya, H, Hayasaka, K, Kato, R, Kawatsu, S, Arahata, Y, Iwai, K, Takeda, A, Washimi, Y, Yoshimura, K, Mizuno, K, Kato, T, Naganawa, S & Ito, K 2007, 'Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients', Radiation Medicine - Medical Imaging and Radiation Oncology, vol. 25, no. 6, pp. 255-262. https://doi.org/10.1007/s11604-007-0132-8

Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. / Nihashi, Takashi; Yatsuya, Hiroshi; Hayasaka, Kazumasa; Kato, Rikio; Kawatsu, Shoji; Arahata, Yutaka; Iwai, Katsushige; Takeda, Akinori; Washimi, Yukihiko; Yoshimura, Kumiko; Mizuno, Kanako; Kato, Takashi; Naganawa, Shinji; Ito, Kengo.

In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 25, No. 6, 01.07.2007, p. 255-262.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients

AU - Nihashi, Takashi

AU - Yatsuya, Hiroshi

AU - Hayasaka, Kazumasa

AU - Kato, Rikio

AU - Kawatsu, Shoji

AU - Arahata, Yutaka

AU - Iwai, Katsushige

AU - Takeda, Akinori

AU - Washimi, Yukihiko

AU - Yoshimura, Kumiko

AU - Mizuno, Kanako

AU - Kato, Takashi

AU - Naganawa, Shinji

AU - Ito, Kengo

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Purpose. The purpose of this study was to evaluate and compare the diagnostic ability of 2-[ 18 F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p- 123 I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). Materials and methods. FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. Conclusion. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

AB - Purpose. The purpose of this study was to evaluate and compare the diagnostic ability of 2-[ 18 F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p- 123 I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). Materials and methods. FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. Conclusion. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

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