Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients

Takashi Nihashi, Hiroshi Yatsuya, Kazumasa Hayasaka, Rikio Kato, Shoji Kawatsu, Yutaka Arahata, Katsushige Iwai, Akinori Takeda, Yukihiko Washimi, Kumiko Yoshimura, Kanako Mizuno, Takashi Kato, Shinji Naganawa, Kengo Ito

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Abstract

Purpose. The purpose of this study was to evaluate and compare the diagnostic ability of 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). Materials and methods. FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. Conclusion. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume25
Issue number6
DOIs
Publication statusPublished - 01-07-2007

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All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Nihashi, T., Yatsuya, H., Hayasaka, K., Kato, R., Kawatsu, S., Arahata, Y., Iwai, K., Takeda, A., Washimi, Y., Yoshimura, K., Mizuno, K., Kato, T., Naganawa, S., & Ito, K. (2007). Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. Radiation Medicine - Medical Imaging and Radiation Oncology, 25(6), 255-262. https://doi.org/10.1007/s11604-007-0132-8