Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds

Yijin Yan, Atsumi Nitta, Tomoko Mizuno, Akira Nakajima, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalBehavioural Brain Research
Volume173
Issue number1
DOIs
Publication statusPublished - 02-10-2006

Fingerprint

Methamphetamine
Morphine
Rolipram
Neomycin
Calcium Channel Blockers
Street Drugs
Calcium Channels
Nifedipine
Pharmaceutical Preparations
Animal Models
nefiracetam
Therapeutics

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Yan, Yijin ; Nitta, Atsumi ; Mizuno, Tomoko ; Nakajima, Akira ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. In: Behavioural Brain Research. 2006 ; Vol. 173, No. 1. pp. 39-46.
@article{af1d77dc90504587abe43383ebd39295,
title = "Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds",
abstract = "Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.",
author = "Yijin Yan and Atsumi Nitta and Tomoko Mizuno and Akira Nakajima and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "2006",
month = "10",
day = "2",
doi = "10.1016/j.bbr.2006.05.029",
language = "English",
volume = "173",
pages = "39--46",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. / Yan, Yijin; Nitta, Atsumi; Mizuno, Tomoko; Nakajima, Akira; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 173, No. 1, 02.10.2006, p. 39-46.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds

AU - Yan, Yijin

AU - Nitta, Atsumi

AU - Mizuno, Tomoko

AU - Nakajima, Akira

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 2006/10/2

Y1 - 2006/10/2

N2 - Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.

AB - Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.

UR - http://www.scopus.com/inward/record.url?scp=33749985646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749985646&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2006.05.029

DO - 10.1016/j.bbr.2006.05.029

M3 - Article

C2 - 16857277

AN - SCOPUS:33749985646

VL - 173

SP - 39

EP - 46

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -