Abstract
Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.
| Original language | English |
|---|---|
| Pages (from-to) | 39-46 |
| Number of pages | 8 |
| Journal | Behavioural Brain Research |
| Volume | 173 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 02-10-2006 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Behavioral Neuroscience
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Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. / Yan, Yijin; Nitta, Atsumi; Mizuno, Tomoko; Nakajima, Akira; Yamada, Kiyofumi; Nabeshima, Toshitaka.
In: Behavioural Brain Research, Vol. 173, No. 1, 02.10.2006, p. 39-46.Research output: Contribution to journal › Article
TY - JOUR
T1 - Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds
AU - Yan, Yijin
AU - Nitta, Atsumi
AU - Mizuno, Tomoko
AU - Nakajima, Akira
AU - Yamada, Kiyofumi
AU - Nabeshima, Toshitaka
PY - 2006/10/2
Y1 - 2006/10/2
N2 - Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.
AB - Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.
UR - http://www.scopus.com/inward/record.url?scp=33749985646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749985646&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2006.05.029
DO - 10.1016/j.bbr.2006.05.029
M3 - Article
VL - 173
SP - 39
EP - 46
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -