Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling

Yoshiki Akatsuka, Edus H. Warren, Ted A. Gooley, Anthony G. Brickner, Ming Tseh Lin, John A. Hansen, Paul J. Martin, David K. Madtes, Victor H. Engelhard, Toshitada Takahashi, Stanley R. Riddell

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Abstract

We recently identified a new minor histocompatibility antigen, termed HA-8, which is presented by human leucocyte antigen (HLA)-A*0201 or HLA-A*0202 and expressed ubiquitously among tissues. A retrospective analysis of 577 Caucasian patients with HLA-A*0201 or A*0202 who had received a haematopoietic stem cell transplant from a human leucocyte antigen (HLA)-identical sibling was conducted to determine whether HA-8 disparity correlated with clinical outcome. HA-8 disparity was detected in 72 recipients, and grades II-IV graft-versus-host disease (GVHD) occurred in 46 (64%). compared with 251 (50%) of the 503 patients without HA-8 disparity. After adjusting for known risk factors for acute GVHD, this difference was statistically significant (odds ratio, 1.8; 95% confidence interval, 1.0-3.1; P = 0.04). However, the hazards of clinical extensive chronic GVHD, overall mortality and recurrent malignancy were not statistically significantly different between the two groups. These data suggest that the increased risk of acute GVHD associated with recipient HA-8 disparity was not sufficient to change other clinical outcomes.

Original languageEnglish
Pages (from-to)671-675
Number of pages5
JournalBritish Journal of Haematology
Volume123
Issue number4
DOIs
Publication statusPublished - 01-11-2003

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Minor Histocompatibility Antigens
Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
HLA Antigens
Siblings
Hematopoietic Stem Cells
Odds Ratio
Confidence Intervals
Transplants
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Akatsuka, Yoshiki ; Warren, Edus H. ; Gooley, Ted A. ; Brickner, Anthony G. ; Lin, Ming Tseh ; Hansen, John A. ; Martin, Paul J. ; Madtes, David K. ; Engelhard, Victor H. ; Takahashi, Toshitada ; Riddell, Stanley R. / Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling. In: British Journal of Haematology. 2003 ; Vol. 123, No. 4. pp. 671-675.
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Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling. / Akatsuka, Yoshiki; Warren, Edus H.; Gooley, Ted A.; Brickner, Anthony G.; Lin, Ming Tseh; Hansen, John A.; Martin, Paul J.; Madtes, David K.; Engelhard, Victor H.; Takahashi, Toshitada; Riddell, Stanley R.

In: British Journal of Haematology, Vol. 123, No. 4, 01.11.2003, p. 671-675.

Research output: Contribution to journalArticle

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AU - Riddell, Stanley R.

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