Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats

Hidekazu Miyagawa, Masaya Hasegawa, Taneo Fukuta, Manabu Amano, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

We investigated changes in learning and memory in aged rats, in relation to motor function and emotional behavior. Male Kbl Wistar aged rats (108- weeks-old) were divided into two groups, memory impaired and non-impaired, based on performance during six training trials in the Morris water maze task. Aged rats with a goal latency longer than the mean plus the 99% confidence limit of young rats, were regarded as memory impaired, whereas those with a goal latency within the range of the 99% confidence limit of the mean of young rats, were considered as memory non-impaired. Although the performance of the memory impaired aged rats in the standard test of the Morris water maze improved after six re-training trials to the level of the non-impaired aged rats and young rats, working memory impairment was evident. There were no differences in motor function and emotional behavior between the impaired and non-impaired aged rats. These results suggest that deficits of learning and memory in memory impaired aged rats can be dissociated from changes in motor function and emotional behavior.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalBehavioural Brain Research
Volume91
Issue number1-2
DOIs
Publication statusPublished - 01-03-1998
Externally publishedYes

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Learning
Spatial Memory
Water
Memory Disorders
Short-Term Memory
Wistar Rats

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Miyagawa, Hidekazu ; Hasegawa, Masaya ; Fukuta, Taneo ; Amano, Manabu ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats. In: Behavioural Brain Research. 1998 ; Vol. 91, No. 1-2. pp. 73-81.
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Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats. / Miyagawa, Hidekazu; Hasegawa, Masaya; Fukuta, Taneo; Amano, Manabu; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 91, No. 1-2, 01.03.1998, p. 73-81.

Research output: Contribution to journalArticle

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