TY - JOUR
T1 - Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis
AU - Jeong, Sangho
AU - Choi, Eunyoung
AU - Petersen, Christine P.
AU - Roland, Joseph T.
AU - Federico, Alessandro
AU - Ippolito, Rossana
AU - D'Armiento, Francesco P.
AU - Nardone, Gerardo
AU - Nagano, Osamu
AU - Saya, Hideyuki
AU - Romano, Marco
AU - Goldenring, James R.
N1 - Publisher Copyright:
© 2016, © Author(s) 2016.
PY - 2017/2
Y1 - 2017/2
N2 - Background: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. Methods: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma. Results: Both AIG and CAG patients demonstrated prominent SPEM and intestinal metaplasia. However, AIG patients displayed significantly lower numbers of infiltrating macrophages and significantly reduced mucosal cell proliferation as compared to CAG patients. Conclusions: These findings indicate that, while both AIG and CAG patients display prominent oxyntic atrophy and metaplasia, the AIG patients do not show proliferative metaplastic lineages that would predispose to adenocarcinoma.
AB - Background: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. Methods: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma. Results: Both AIG and CAG patients demonstrated prominent SPEM and intestinal metaplasia. However, AIG patients displayed significantly lower numbers of infiltrating macrophages and significantly reduced mucosal cell proliferation as compared to CAG patients. Conclusions: These findings indicate that, while both AIG and CAG patients display prominent oxyntic atrophy and metaplasia, the AIG patients do not show proliferative metaplastic lineages that would predispose to adenocarcinoma.
KW - CD44 variant 9
KW - DMBT1
KW - Spasmolytic polypeptide-expressing metaplasia
KW - gastritis
KW - intestinal metaplasia
KW - macrophage
KW - neutrophil
UR - http://www.scopus.com/inward/record.url?scp=85011629928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011629928&partnerID=8YFLogxK
U2 - 10.1177/2050640616644142
DO - 10.1177/2050640616644142
M3 - Article
AN - SCOPUS:85011629928
SN - 2050-6406
VL - 5
SP - 37
EP - 44
JO - United European Gastroenterology Journal
JF - United European Gastroenterology Journal
IS - 1
ER -