TY - JOUR
T1 - Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear
AU - Yamaguchi, Takashi
AU - Danjo, Teruko
AU - Pastan, Ira
AU - Hikida, Takatoshi
AU - Nakanishi, Shigetada
N1 - Funding Information:
We thank S. Chaki and T. Shimazaki for technical advice on the behavioral analysis. This work was supported by Research Grants-in-Aid 22220005 (S.N.), 23120011 (T.H. and S.N.), and 23680034 (T.H.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by grants from the JST PRESTO Program (T.H.), the Takeda Science Foundation (S.N.), and the Naito Foundation (T.H.).
PY - 2013/5/8
Y1 - 2013/5/8
N2 - The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We established a transgenic mouse model in which the TS and BAC projection neurons were visualized by GFP fluorescence and selectively eliminated by immunotoxin-mediated cell targeting. The linkage between the TS/BAC and the MHb constitutes two parallel pathways composed of the TS-ventral MHb, the core part of the interpeduncular nucleus (IPN), and the BAC-dorsal MHb, the peripheral part of the IPN. Ablation of the TS and BAC projection neurons selectively impaired anxiety and enhanced fear responses and learning, respectively. Inputs from the TS and BAC to the MHb are thus segregated by two parallel pathways and play specialized roles in controlling emotional behaviors
AB - The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We established a transgenic mouse model in which the TS and BAC projection neurons were visualized by GFP fluorescence and selectively eliminated by immunotoxin-mediated cell targeting. The linkage between the TS/BAC and the MHb constitutes two parallel pathways composed of the TS-ventral MHb, the core part of the interpeduncular nucleus (IPN), and the BAC-dorsal MHb, the peripheral part of the IPN. Ablation of the TS and BAC projection neurons selectively impaired anxiety and enhanced fear responses and learning, respectively. Inputs from the TS and BAC to the MHb are thus segregated by two parallel pathways and play specialized roles in controlling emotional behaviors
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U2 - 10.1016/j.neuron.2013.02.035
DO - 10.1016/j.neuron.2013.02.035
M3 - Article
C2 - 23602500
AN - SCOPUS:84877340712
SN - 0896-6273
VL - 78
SP - 537
EP - 544
JO - Neuron
JF - Neuron
IS - 3
ER -