Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear

Takashi Yamaguchi, Teruko Danjo, Ira Pastan, Takatoshi Hikida, Shigetada Nakanishi

Research output: Contribution to journalArticlepeer-review

138 Citations (Scopus)


The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We established a transgenic mouse model in which the TS and BAC projection neurons were visualized by GFP fluorescence and selectively eliminated by immunotoxin-mediated cell targeting. The linkage between the TS/BAC and the MHb constitutes two parallel pathways composed of the TS-ventral MHb, the core part of the interpeduncular nucleus (IPN), and the BAC-dorsal MHb, the peripheral part of the IPN. Ablation of the TS and BAC projection neurons selectively impaired anxiety and enhanced fear responses and learning, respectively. Inputs from the TS and BAC to the MHb are thus segregated by two parallel pathways and play specialized roles in controlling emotional behaviors

Original languageEnglish
Pages (from-to)537-544
Number of pages8
Issue number3
Publication statusPublished - 08-05-2013

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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