Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals

Tetsushi Yoshikawa, S. Suga, Y. Asano, T. Yazaki, H. Kodama, T. Ozaki

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

The transfer of IgG antibodies to a causative agent of exanthem subitum (human herpesvirus-6) from mother to infant was examined with an indirect immunofluorescence assay. Of 20 mothers, 85% had the antibody more than 1:10, and the significantly higher level of the antibody was found in the cord blood with a positive rate of 95%. A mean ratio of cord blood to maternal antibody titer was 1.63. A total of 301 sera from healthy individuals was examined for the age-specific prevalence of antibody to the virus. In the first 2 months of life, 87% of infants had the antibody; the positive rate and the level of antibody decreased during the first 6 months of life with the lowest positive rate of 6% at 4 to 5 months of age. After 6 months of age, they increased gradually and reached the highest level at 1 year of age with the positive rate of 86%. From 2 years of age, the prevalence of the antibody was almost stable (69% to 76%) and similar to those in adolescents and adults.

Original languageEnglish
Pages (from-to)675-677
Number of pages3
JournalPediatrics
Volume84
Issue number4
Publication statusPublished - 01-01-1989

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Human Herpesvirus 6
Exanthema
Antibodies
Mothers
Fetal Blood
Indirect Fluorescent Antibody Technique
Immunoglobulin G
Viruses

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Yoshikawa, Tetsushi ; Suga, S. ; Asano, Y. ; Yazaki, T. ; Kodama, H. ; Ozaki, T. / Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. In: Pediatrics. 1989 ; Vol. 84, No. 4. pp. 675-677.
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Yoshikawa, T, Suga, S, Asano, Y, Yazaki, T, Kodama, H & Ozaki, T 1989, 'Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals', Pediatrics, vol. 84, no. 4, pp. 675-677.

Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. / Yoshikawa, Tetsushi; Suga, S.; Asano, Y.; Yazaki, T.; Kodama, H.; Ozaki, T.

In: Pediatrics, Vol. 84, No. 4, 01.01.1989, p. 675-677.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

AU - Suga, S.

AU - Asano, Y.

AU - Yazaki, T.

AU - Kodama, H.

AU - Ozaki, T.

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