TY - JOUR
T1 - Distribution of NADPH-diaphorase in the cerebral blood vessels of rats
T2 - a histochemical study
AU - Tomimoto, Hidekazu
AU - Akiguchi, Ichiro
AU - Wakita, Hideaki
AU - Nakamura, Shinichi
AU - Kimura, Jun
PY - 1993/6/25
Y1 - 1993/6/25
N2 - NADPH-diaphorase (neuronal nitric oxide synthase) activity in the cerebral blood vessels was investigated by light and electron microscopic histochemistry to elucidate the sites of nitric oxide production. Networks of adventitial nerves containing NADPH-diaphorase were distributed in all parts of the circle of Willis. However, NADPH-diaphorase activity in adventitial nerves was much sparser in the region of the posterior cerebral artery, and absent in the pial arteries smaller than 100 μm in diameter. Endothelial cells were intensely stained in arteries and arterioles. These results support the hypothesis that vascular tone is regulated by nitric oxide, which is derived from endothelial cells and adventitial nerves.
AB - NADPH-diaphorase (neuronal nitric oxide synthase) activity in the cerebral blood vessels was investigated by light and electron microscopic histochemistry to elucidate the sites of nitric oxide production. Networks of adventitial nerves containing NADPH-diaphorase were distributed in all parts of the circle of Willis. However, NADPH-diaphorase activity in adventitial nerves was much sparser in the region of the posterior cerebral artery, and absent in the pial arteries smaller than 100 μm in diameter. Endothelial cells were intensely stained in arteries and arterioles. These results support the hypothesis that vascular tone is regulated by nitric oxide, which is derived from endothelial cells and adventitial nerves.
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U2 - 10.1016/0304-3940(93)90450-Y
DO - 10.1016/0304-3940(93)90450-Y
M3 - Article
C2 - 7692358
AN - SCOPUS:0027164631
VL - 156
SP - 105
EP - 108
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -