Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: A multicenter study (JOSL CT study)

Takashi Hirai, Toshitaka Yoshii, Narihito Nagoshi, Kazuhiro Takeuchi, Kanji Mori, Shuta Ushio, Akio Iwanami, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko AbematsuHirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masao Koda, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification. Methods: Data were collected from 20 institutions in Japan. Three hundred and twenty-two patients with a diagnosis of cervical OPLL were included. The OPLL index (OP index), defined as the sum of the vertebral body and intervertebral disc levels where OPLL is present, was used to determine disease severity. An OP index ≥20 was defined as severe OPLL. The prevalence of OPLL at each level of the thoracic and lumbar spinal segments was calculated. Results: Women were more likely to have ossified lesions in the thoracolumbar spine than men. Severe OPLL was significantly more common in women than in men (20% vs. 4.5%). For thoracic vertebral OPLL, the most frequently affected was the T1 segment in both men and women, followed by the T1/2 and T3/4 intervertebral levels in men and women, respectively. Ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men with severe OPLL, whereas OPLL was more diffusely distributed in the thoracic spine in women with severe OPLL. Conclusion: Thoracolumbar OPLL occurred most often at T1 in men and at T3/4 in women. In severe OPLL cases, although ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men, OPLL could be observed more diffusely in the thoracic spine in women.

Original languageEnglish
Article number107
JournalBMC Musculoskeletal Disorders
Volume19
Issue number1
DOIs
Publication statusPublished - 05-04-2018

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Ossification of Posterior Longitudinal Ligament
Multicenter Studies
Thorax
Spine

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Orthopedics and Sports Medicine

Cite this

Hirai, Takashi ; Yoshii, Toshitaka ; Nagoshi, Narihito ; Takeuchi, Kazuhiro ; Mori, Kanji ; Ushio, Shuta ; Iwanami, Akio ; Yamada, Tsuyoshi ; Seki, Shoji ; Tsuji, Takashi ; Fujiyoshi, Kanehiro ; Furukawa, Mitsuru ; Nishimura, Soraya ; Wada, Kanichiro ; Furuya, Takeo ; Matsuyama, Yukihiro ; Hasegawa, Tomohiko ; Takeshita, Katsushi ; Kimura, Atsushi ; Abematsu, Masahiko ; Haro, Hirotaka ; Ohba, Tetsuro ; Watanabe, Masahiko ; Katoh, Hiroyuki ; Watanabe, Kei ; Ozawa, Hiroshi ; Kanno, Haruo ; Imagama, Shiro ; Ando, Kei ; Fujibayashi, Shunsuke ; Koda, Masao ; Yamazaki, Masashi ; Matsumoto, Morio ; Nakamura, Masaya ; Okawa, Atsushi ; Kawaguchi, Yoshiharu. / Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification : A multicenter study (JOSL CT study). In: BMC Musculoskeletal Disorders. 2018 ; Vol. 19, No. 1.
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title = "Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: A multicenter study (JOSL CT study)",
abstract = "Background: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification. Methods: Data were collected from 20 institutions in Japan. Three hundred and twenty-two patients with a diagnosis of cervical OPLL were included. The OPLL index (OP index), defined as the sum of the vertebral body and intervertebral disc levels where OPLL is present, was used to determine disease severity. An OP index ≥20 was defined as severe OPLL. The prevalence of OPLL at each level of the thoracic and lumbar spinal segments was calculated. Results: Women were more likely to have ossified lesions in the thoracolumbar spine than men. Severe OPLL was significantly more common in women than in men (20{\%} vs. 4.5{\%}). For thoracic vertebral OPLL, the most frequently affected was the T1 segment in both men and women, followed by the T1/2 and T3/4 intervertebral levels in men and women, respectively. Ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men with severe OPLL, whereas OPLL was more diffusely distributed in the thoracic spine in women with severe OPLL. Conclusion: Thoracolumbar OPLL occurred most often at T1 in men and at T3/4 in women. In severe OPLL cases, although ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men, OPLL could be observed more diffusely in the thoracic spine in women.",
author = "Takashi Hirai and Toshitaka Yoshii and Narihito Nagoshi and Kazuhiro Takeuchi and Kanji Mori and Shuta Ushio and Akio Iwanami and Tsuyoshi Yamada and Shoji Seki and Takashi Tsuji and Kanehiro Fujiyoshi and Mitsuru Furukawa and Soraya Nishimura and Kanichiro Wada and Takeo Furuya and Yukihiro Matsuyama and Tomohiko Hasegawa and Katsushi Takeshita and Atsushi Kimura and Masahiko Abematsu and Hirotaka Haro and Tetsuro Ohba and Masahiko Watanabe and Hiroyuki Katoh and Kei Watanabe and Hiroshi Ozawa and Haruo Kanno and Shiro Imagama and Kei Ando and Shunsuke Fujibayashi and Masao Koda and Masashi Yamazaki and Morio Matsumoto and Masaya Nakamura and Atsushi Okawa and Yoshiharu Kawaguchi",
year = "2018",
month = "4",
day = "5",
doi = "10.1186/s12891-018-2009-7",
language = "English",
volume = "19",
journal = "BMC Musculoskeletal Disorders",
issn = "1471-2474",
publisher = "BioMed Central",
number = "1",

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Hirai, T, Yoshii, T, Nagoshi, N, Takeuchi, K, Mori, K, Ushio, S, Iwanami, A, Yamada, T, Seki, S, Tsuji, T, Fujiyoshi, K, Furukawa, M, Nishimura, S, Wada, K, Furuya, T, Matsuyama, Y, Hasegawa, T, Takeshita, K, Kimura, A, Abematsu, M, Haro, H, Ohba, T, Watanabe, M, Katoh, H, Watanabe, K, Ozawa, H, Kanno, H, Imagama, S, Ando, K, Fujibayashi, S, Koda, M, Yamazaki, M, Matsumoto, M, Nakamura, M, Okawa, A & Kawaguchi, Y 2018, 'Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: A multicenter study (JOSL CT study)', BMC Musculoskeletal Disorders, vol. 19, no. 1, 107. https://doi.org/10.1186/s12891-018-2009-7

Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification : A multicenter study (JOSL CT study). / Hirai, Takashi; Yoshii, Toshitaka; Nagoshi, Narihito; Takeuchi, Kazuhiro; Mori, Kanji; Ushio, Shuta; Iwanami, Akio; Yamada, Tsuyoshi; Seki, Shoji; Tsuji, Takashi; Fujiyoshi, Kanehiro; Furukawa, Mitsuru; Nishimura, Soraya; Wada, Kanichiro; Furuya, Takeo; Matsuyama, Yukihiro; Hasegawa, Tomohiko; Takeshita, Katsushi; Kimura, Atsushi; Abematsu, Masahiko; Haro, Hirotaka; Ohba, Tetsuro; Watanabe, Masahiko; Katoh, Hiroyuki; Watanabe, Kei; Ozawa, Hiroshi; Kanno, Haruo; Imagama, Shiro; Ando, Kei; Fujibayashi, Shunsuke; Koda, Masao; Yamazaki, Masashi; Matsumoto, Morio; Nakamura, Masaya; Okawa, Atsushi; Kawaguchi, Yoshiharu.

In: BMC Musculoskeletal Disorders, Vol. 19, No. 1, 107, 05.04.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification

T2 - A multicenter study (JOSL CT study)

AU - Hirai, Takashi

AU - Yoshii, Toshitaka

AU - Nagoshi, Narihito

AU - Takeuchi, Kazuhiro

AU - Mori, Kanji

AU - Ushio, Shuta

AU - Iwanami, Akio

AU - Yamada, Tsuyoshi

AU - Seki, Shoji

AU - Tsuji, Takashi

AU - Fujiyoshi, Kanehiro

AU - Furukawa, Mitsuru

AU - Nishimura, Soraya

AU - Wada, Kanichiro

AU - Furuya, Takeo

AU - Matsuyama, Yukihiro

AU - Hasegawa, Tomohiko

AU - Takeshita, Katsushi

AU - Kimura, Atsushi

AU - Abematsu, Masahiko

AU - Haro, Hirotaka

AU - Ohba, Tetsuro

AU - Watanabe, Masahiko

AU - Katoh, Hiroyuki

AU - Watanabe, Kei

AU - Ozawa, Hiroshi

AU - Kanno, Haruo

AU - Imagama, Shiro

AU - Ando, Kei

AU - Fujibayashi, Shunsuke

AU - Koda, Masao

AU - Yamazaki, Masashi

AU - Matsumoto, Morio

AU - Nakamura, Masaya

AU - Okawa, Atsushi

AU - Kawaguchi, Yoshiharu

PY - 2018/4/5

Y1 - 2018/4/5

N2 - Background: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification. Methods: Data were collected from 20 institutions in Japan. Three hundred and twenty-two patients with a diagnosis of cervical OPLL were included. The OPLL index (OP index), defined as the sum of the vertebral body and intervertebral disc levels where OPLL is present, was used to determine disease severity. An OP index ≥20 was defined as severe OPLL. The prevalence of OPLL at each level of the thoracic and lumbar spinal segments was calculated. Results: Women were more likely to have ossified lesions in the thoracolumbar spine than men. Severe OPLL was significantly more common in women than in men (20% vs. 4.5%). For thoracic vertebral OPLL, the most frequently affected was the T1 segment in both men and women, followed by the T1/2 and T3/4 intervertebral levels in men and women, respectively. Ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men with severe OPLL, whereas OPLL was more diffusely distributed in the thoracic spine in women with severe OPLL. Conclusion: Thoracolumbar OPLL occurred most often at T1 in men and at T3/4 in women. In severe OPLL cases, although ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men, OPLL could be observed more diffusely in the thoracic spine in women.

AB - Background: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification. Methods: Data were collected from 20 institutions in Japan. Three hundred and twenty-two patients with a diagnosis of cervical OPLL were included. The OPLL index (OP index), defined as the sum of the vertebral body and intervertebral disc levels where OPLL is present, was used to determine disease severity. An OP index ≥20 was defined as severe OPLL. The prevalence of OPLL at each level of the thoracic and lumbar spinal segments was calculated. Results: Women were more likely to have ossified lesions in the thoracolumbar spine than men. Severe OPLL was significantly more common in women than in men (20% vs. 4.5%). For thoracic vertebral OPLL, the most frequently affected was the T1 segment in both men and women, followed by the T1/2 and T3/4 intervertebral levels in men and women, respectively. Ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men with severe OPLL, whereas OPLL was more diffusely distributed in the thoracic spine in women with severe OPLL. Conclusion: Thoracolumbar OPLL occurred most often at T1 in men and at T3/4 in women. In severe OPLL cases, although ossified lesions were frequently seen at the intervertebral and vertebral levels around the cervicothoracic and thoracolumbar junctions in men, OPLL could be observed more diffusely in the thoracic spine in women.

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U2 - 10.1186/s12891-018-2009-7

DO - 10.1186/s12891-018-2009-7

M3 - Article

C2 - 29621987

AN - SCOPUS:85044921969

VL - 19

JO - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

SN - 1471-2474

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