TY - JOUR
T1 - Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice
AU - Morishita, Yuki
AU - Yoshioka, Yasuo
AU - Takimura, Yuya
AU - Shimizu, Yuki
AU - Namba, Yuki
AU - Nojiri, Nao
AU - Ishizaka, Takuya
AU - Takao, Keizo
AU - Yamashita, Fumiyoshi
AU - Takuma, Kazuhiro
AU - Ago, Yukio
AU - Nagano, Kazuya
AU - Mukai, Yohei
AU - Kamada, Haruhiko
AU - Tsunoda, Shin Ichi
AU - Saito, Shigeru
AU - Matsuda, Toshio
AU - Hashida, Mitsuru
AU - Miyakawa, Tsuyoshi
AU - Higashisaka, Kazuma
AU - Tsutsumi, Yasuo
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (no. 25136712 to Y. Yoshioka, no. 13J00945 to Y. Morishita, no. 26242055 to Y. Tsutsumi, and no. 15K12540 to Y. Tsutsumi); by a Health Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan (no. H25-kagaku-ippan-005 to Y. Tsutsumi); and by The Uehara Memorial Foundation (to Y. Yoshioka). The authors wish to acknowledge the Division for Medical Research Engineering, Nagoya University Graduate School of Medicine, for the use of energy dispersive X-ray spectroscopy equipment.
Publisher Copyright:
© 2016 American Chemical Society.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/9/27
Y1 - 2016/9/27
N2 - Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice to investigate the safety of nanoparticle use during lactation. When Ag and Au nanoparticles were intravenously administered to lactating mice, the nanoparticles were distributed to breast milk without producing apparent damage to the mammary gland, and the amount of Ag nanoparticles distributed to breast milk increased with decreasing particle size. Orally administered Ag nanoparticles were also distributed to breast milk and subsequently to the brains of breast-fed pups. Ten-nanometer Ag nanoparticles were retained longer in the pups' brains than in their livers and lungs. Nevertheless, no significant behavioral changes were observed in offspring breast-fed by dams that had received orally administered 10 nm Ag nanoparticles. These data provide basic information for evaluating the safety of nanoparticle use during lactation.
AB - Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice to investigate the safety of nanoparticle use during lactation. When Ag and Au nanoparticles were intravenously administered to lactating mice, the nanoparticles were distributed to breast milk without producing apparent damage to the mammary gland, and the amount of Ag nanoparticles distributed to breast milk increased with decreasing particle size. Orally administered Ag nanoparticles were also distributed to breast milk and subsequently to the brains of breast-fed pups. Ten-nanometer Ag nanoparticles were retained longer in the pups' brains than in their livers and lungs. Nevertheless, no significant behavioral changes were observed in offspring breast-fed by dams that had received orally administered 10 nm Ag nanoparticles. These data provide basic information for evaluating the safety of nanoparticle use during lactation.
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U2 - 10.1021/acsnano.6b01782
DO - 10.1021/acsnano.6b01782
M3 - Article
C2 - 27498759
AN - SCOPUS:84989196123
VL - 10
SP - 8180
EP - 8191
JO - ACS Nano
JF - ACS Nano
SN - 1936-0851
IS - 9
ER -