Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

Yuki Morishita, Yasuo Yoshioka, Yuya Takimura, Yuki Shimizu, Yuki Namba, Nao Nojiri, Takuya Ishizaka, Keizo Takao, Fumiyoshi Yamashita, Kazuhiro Takuma, Yukio Ago, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin Ichi Tsunoda, Shigeru Saito, Toshio Matsuda, Mitsuru Hashida, Tsuyoshi Miyakawa, Kazuma HigashisakaYasuo Tsutsumi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice to investigate the safety of nanoparticle use during lactation. When Ag and Au nanoparticles were intravenously administered to lactating mice, the nanoparticles were distributed to breast milk without producing apparent damage to the mammary gland, and the amount of Ag nanoparticles distributed to breast milk increased with decreasing particle size. Orally administered Ag nanoparticles were also distributed to breast milk and subsequently to the brains of breast-fed pups. Ten-nanometer Ag nanoparticles were retained longer in the pups' brains than in their livers and lungs. Nevertheless, no significant behavioral changes were observed in offspring breast-fed by dams that had received orally administered 10 nm Ag nanoparticles. These data provide basic information for evaluating the safety of nanoparticle use during lactation.

Original languageEnglish
Pages (from-to)8180-8191
Number of pages12
JournalACS Nano
Volume10
Issue number9
DOIs
Publication statusPublished - 27-09-2016

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biological effects
milk
Silver
breast
mice
silver
Nanoparticles
nanoparticles
safety
brain
Brain
mammary glands
Human Milk
rodents
dams
liver
Liver
lungs
Dams
Particle size

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Morishita, Y., Yoshioka, Y., Takimura, Y., Shimizu, Y., Namba, Y., Nojiri, N., ... Tsutsumi, Y. (2016). Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. ACS Nano, 10(9), 8180-8191. https://doi.org/10.1021/acsnano.6b01782
Morishita, Yuki ; Yoshioka, Yasuo ; Takimura, Yuya ; Shimizu, Yuki ; Namba, Yuki ; Nojiri, Nao ; Ishizaka, Takuya ; Takao, Keizo ; Yamashita, Fumiyoshi ; Takuma, Kazuhiro ; Ago, Yukio ; Nagano, Kazuya ; Mukai, Yohei ; Kamada, Haruhiko ; Tsunoda, Shin Ichi ; Saito, Shigeru ; Matsuda, Toshio ; Hashida, Mitsuru ; Miyakawa, Tsuyoshi ; Higashisaka, Kazuma ; Tsutsumi, Yasuo. / Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. In: ACS Nano. 2016 ; Vol. 10, No. 9. pp. 8180-8191.
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abstract = "Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice to investigate the safety of nanoparticle use during lactation. When Ag and Au nanoparticles were intravenously administered to lactating mice, the nanoparticles were distributed to breast milk without producing apparent damage to the mammary gland, and the amount of Ag nanoparticles distributed to breast milk increased with decreasing particle size. Orally administered Ag nanoparticles were also distributed to breast milk and subsequently to the brains of breast-fed pups. Ten-nanometer Ag nanoparticles were retained longer in the pups' brains than in their livers and lungs. Nevertheless, no significant behavioral changes were observed in offspring breast-fed by dams that had received orally administered 10 nm Ag nanoparticles. These data provide basic information for evaluating the safety of nanoparticle use during lactation.",
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Morishita, Y, Yoshioka, Y, Takimura, Y, Shimizu, Y, Namba, Y, Nojiri, N, Ishizaka, T, Takao, K, Yamashita, F, Takuma, K, Ago, Y, Nagano, K, Mukai, Y, Kamada, H, Tsunoda, SI, Saito, S, Matsuda, T, Hashida, M, Miyakawa, T, Higashisaka, K & Tsutsumi, Y 2016, 'Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice', ACS Nano, vol. 10, no. 9, pp. 8180-8191. https://doi.org/10.1021/acsnano.6b01782

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. / Morishita, Yuki; Yoshioka, Yasuo; Takimura, Yuya; Shimizu, Yuki; Namba, Yuki; Nojiri, Nao; Ishizaka, Takuya; Takao, Keizo; Yamashita, Fumiyoshi; Takuma, Kazuhiro; Ago, Yukio; Nagano, Kazuya; Mukai, Yohei; Kamada, Haruhiko; Tsunoda, Shin Ichi; Saito, Shigeru; Matsuda, Toshio; Hashida, Mitsuru; Miyakawa, Tsuyoshi; Higashisaka, Kazuma; Tsutsumi, Yasuo.

In: ACS Nano, Vol. 10, No. 9, 27.09.2016, p. 8180-8191.

Research output: Contribution to journalArticle

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T1 - Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

AU - Morishita, Yuki

AU - Yoshioka, Yasuo

AU - Takimura, Yuya

AU - Shimizu, Yuki

AU - Namba, Yuki

AU - Nojiri, Nao

AU - Ishizaka, Takuya

AU - Takao, Keizo

AU - Yamashita, Fumiyoshi

AU - Takuma, Kazuhiro

AU - Ago, Yukio

AU - Nagano, Kazuya

AU - Mukai, Yohei

AU - Kamada, Haruhiko

AU - Tsunoda, Shin Ichi

AU - Saito, Shigeru

AU - Matsuda, Toshio

AU - Hashida, Mitsuru

AU - Miyakawa, Tsuyoshi

AU - Higashisaka, Kazuma

AU - Tsutsumi, Yasuo

PY - 2016/9/27

Y1 - 2016/9/27

N2 - Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice to investigate the safety of nanoparticle use during lactation. When Ag and Au nanoparticles were intravenously administered to lactating mice, the nanoparticles were distributed to breast milk without producing apparent damage to the mammary gland, and the amount of Ag nanoparticles distributed to breast milk increased with decreasing particle size. Orally administered Ag nanoparticles were also distributed to breast milk and subsequently to the brains of breast-fed pups. Ten-nanometer Ag nanoparticles were retained longer in the pups' brains than in their livers and lungs. Nevertheless, no significant behavioral changes were observed in offspring breast-fed by dams that had received orally administered 10 nm Ag nanoparticles. These data provide basic information for evaluating the safety of nanoparticle use during lactation.

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Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N et al. Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. ACS Nano. 2016 Sep 27;10(9):8180-8191. https://doi.org/10.1021/acsnano.6b01782