Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization

Hiroshi Yamaguchi, Hiroaki Nagase, Yusuke Ishida, Daisaku Toyoshima, Azusa Maruyama, Kazumi Tomioka, Tsukasa Tanaka, Masahiro Nishiyama, Kyoko Fujita, Mariko Ikeda, Kandai Nozu, Ichiro Morioka, Noriyuki Nishimura, Hiroshi Kurosawa, Satoshi Takada, Yoshiyuki Uetani, Kazumoto Iijima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several studies describing the diurnal occurrence of febrile seizures have reported greater seizure frequency early or late in the evening relative to midnight or early morning. However, no articles have reported on the diurnal occurrence of complex febrile seizure. Moreover, no studies have addressed the relationship between seizure severity and diurnal occurrence. We retrospectively evaluated complex febrile seizures in 462 children needing hospitalization, and investigated the relationship between severity and diurnal occurrence according to four categorized time periods (morning, afternoon, evening, and night). Our study showed that complex febrile seizures occurred most often in the evening, peaking around 18:00 (18:00–18:59), and least often at night (02:00–02:59). In addition, the frequency with which patients developed status epilepticus or needed anticonvulsant treatments was also lower during the night. However, the seizure duration and the proportion of the patients who needed anticonvulsant treatment were the same among the four time periods. Furthermore, we compared three subclasses (repeated episodes of convulsions, focal seizures, and prolonged seizures (≧ 15 min)), two of the complex features (focal seizures and prolonged seizures), and all complex features among the four time periods. However, they were the same among the four time periods. Taken together, our data indicate that although the severity of seizures was stable over a 24-hour period, the occurrence of seizures in our cohort of pediatric patients with complex febrile seizures requiring hospitalization was highest in the evening and lowest at night.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalEpilepsy and Behavior
Volume80
DOIs
Publication statusPublished - 01-03-2018

Fingerprint

Febrile Seizures
Seizures
Hospitalization
Pediatrics
Anticonvulsants
Status Epilepticus

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Yamaguchi, H., Nagase, H., Ishida, Y., Toyoshima, D., Maruyama, A., Tomioka, K., ... Iijima, K. (2018). Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization. Epilepsy and Behavior, 80, 280-284. https://doi.org/10.1016/j.yebeh.2018.01.015
Yamaguchi, Hiroshi ; Nagase, Hiroaki ; Ishida, Yusuke ; Toyoshima, Daisaku ; Maruyama, Azusa ; Tomioka, Kazumi ; Tanaka, Tsukasa ; Nishiyama, Masahiro ; Fujita, Kyoko ; Ikeda, Mariko ; Nozu, Kandai ; Morioka, Ichiro ; Nishimura, Noriyuki ; Kurosawa, Hiroshi ; Takada, Satoshi ; Uetani, Yoshiyuki ; Iijima, Kazumoto. / Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization. In: Epilepsy and Behavior. 2018 ; Vol. 80. pp. 280-284.
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abstract = "Several studies describing the diurnal occurrence of febrile seizures have reported greater seizure frequency early or late in the evening relative to midnight or early morning. However, no articles have reported on the diurnal occurrence of complex febrile seizure. Moreover, no studies have addressed the relationship between seizure severity and diurnal occurrence. We retrospectively evaluated complex febrile seizures in 462 children needing hospitalization, and investigated the relationship between severity and diurnal occurrence according to four categorized time periods (morning, afternoon, evening, and night). Our study showed that complex febrile seizures occurred most often in the evening, peaking around 18:00 (18:00–18:59), and least often at night (02:00–02:59). In addition, the frequency with which patients developed status epilepticus or needed anticonvulsant treatments was also lower during the night. However, the seizure duration and the proportion of the patients who needed anticonvulsant treatment were the same among the four time periods. Furthermore, we compared three subclasses (repeated episodes of convulsions, focal seizures, and prolonged seizures (≧ 15 min)), two of the complex features (focal seizures and prolonged seizures), and all complex features among the four time periods. However, they were the same among the four time periods. Taken together, our data indicate that although the severity of seizures was stable over a 24-hour period, the occurrence of seizures in our cohort of pediatric patients with complex febrile seizures requiring hospitalization was highest in the evening and lowest at night.",
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Yamaguchi, H, Nagase, H, Ishida, Y, Toyoshima, D, Maruyama, A, Tomioka, K, Tanaka, T, Nishiyama, M, Fujita, K, Ikeda, M, Nozu, K, Morioka, I, Nishimura, N, Kurosawa, H, Takada, S, Uetani, Y & Iijima, K 2018, 'Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization', Epilepsy and Behavior, vol. 80, pp. 280-284. https://doi.org/10.1016/j.yebeh.2018.01.015

Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization. / Yamaguchi, Hiroshi; Nagase, Hiroaki; Ishida, Yusuke; Toyoshima, Daisaku; Maruyama, Azusa; Tomioka, Kazumi; Tanaka, Tsukasa; Nishiyama, Masahiro; Fujita, Kyoko; Ikeda, Mariko; Nozu, Kandai; Morioka, Ichiro; Nishimura, Noriyuki; Kurosawa, Hiroshi; Takada, Satoshi; Uetani, Yoshiyuki; Iijima, Kazumoto.

In: Epilepsy and Behavior, Vol. 80, 01.03.2018, p. 280-284.

Research output: Contribution to journalArticle

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T1 - Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization

AU - Yamaguchi, Hiroshi

AU - Nagase, Hiroaki

AU - Ishida, Yusuke

AU - Toyoshima, Daisaku

AU - Maruyama, Azusa

AU - Tomioka, Kazumi

AU - Tanaka, Tsukasa

AU - Nishiyama, Masahiro

AU - Fujita, Kyoko

AU - Ikeda, Mariko

AU - Nozu, Kandai

AU - Morioka, Ichiro

AU - Nishimura, Noriyuki

AU - Kurosawa, Hiroshi

AU - Takada, Satoshi

AU - Uetani, Yoshiyuki

AU - Iijima, Kazumoto

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N2 - Several studies describing the diurnal occurrence of febrile seizures have reported greater seizure frequency early or late in the evening relative to midnight or early morning. However, no articles have reported on the diurnal occurrence of complex febrile seizure. Moreover, no studies have addressed the relationship between seizure severity and diurnal occurrence. We retrospectively evaluated complex febrile seizures in 462 children needing hospitalization, and investigated the relationship between severity and diurnal occurrence according to four categorized time periods (morning, afternoon, evening, and night). Our study showed that complex febrile seizures occurred most often in the evening, peaking around 18:00 (18:00–18:59), and least often at night (02:00–02:59). In addition, the frequency with which patients developed status epilepticus or needed anticonvulsant treatments was also lower during the night. However, the seizure duration and the proportion of the patients who needed anticonvulsant treatment were the same among the four time periods. Furthermore, we compared three subclasses (repeated episodes of convulsions, focal seizures, and prolonged seizures (≧ 15 min)), two of the complex features (focal seizures and prolonged seizures), and all complex features among the four time periods. However, they were the same among the four time periods. Taken together, our data indicate that although the severity of seizures was stable over a 24-hour period, the occurrence of seizures in our cohort of pediatric patients with complex febrile seizures requiring hospitalization was highest in the evening and lowest at night.

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