DNA methylation as a molecular biomarker in gastric cancer

Tomomitsu Tahara, Tomiyasu Arisawa

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

DNA methylation plays a significant role in gastric carcinogenesis. The CpG island methylator phenotype (CIMP) characterizes distinct subtypes of gastric cancer (GC) and the relationship between specific methylation patterns and clinicopathological features has been evaluated. Altered DNA methylation is also observed in Helicobacter pylori-infected gastric mucosa, and its potential utility for GC risk estimation has been suggested. The ability to detect small amounts of methylated DNA among tissues allows us to use DNA methylation as a molecular biomarker in GC in a variety of samples, including serum, plasma and gastric washes. The DNA methylation status of nontargeted tissue, particularly blood, has been associated with predisposition to GC. We focus on the recent development of DNA methylation-based biomarkers in GC.

Original languageEnglish
Pages (from-to)475-486
Number of pages12
JournalEpigenomics
Volume7
Issue number3
DOIs
Publication statusPublished - 01-06-2015

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

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