Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan?

Masaki Tsuboi, Yukiharu Hasegawa, Yukihiro Matsuyama, Sadao Suzuki, Koji Suzuki, Shiro Imagama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

There are several reports from Europe and the United States on mortality from musculoskeletal degenerative diseases; however, no reports have been published from Japan. This study is the first that has examined whether musculoskeletal degenerative diseases affect life prognosis in Japan. As many as 944 persons who were 60 years of age and older and who underwent one or more musculoskeletal checkups (knee, lower back, and bone mineral density examination) were enrolled. Survival and death after 10 years were examined. For each knee, lower back, and bone mineral density examination, subjects were divided into normal and abnormal groups. For each of the examinations (knee, lower back, or bone mineral density), 10-year mortality was compared between the two groups. Also, causes of death were examined after 10 years. As many as 805 subjects survived and 125 died. For those with and without osteoarthritis of the knee, mortality after 10 years was 17 and 10%, respectively. For those with and without lower back abnormalities, mortality after 10 years was 12 and 14%, respectively. For those with or without low bone mineral density, mortality after 10 years was 17 and 10%, respectively. Multivariate analysis adjusted for age, gender, body mass index, and lifestyle revealed that odds ratio of death after 10 years was 2.32 and 2.33 in the presence of osteoarthritis of the knee and a low bone mineral density, respectively, and thus the risk of death after 10 years was significantly high. With regard to the cause of death, cerebrovascular and cardiovascular diseases were most frequently evident in patients with osteoarthritis of the knee. Musculoskeletal degenerative diseases influence mortality after 10 years.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalJournal of Bone and Mineral Metabolism
Volume29
Issue number2
DOIs
Publication statusPublished - 01-03-2011

Fingerprint

Musculoskeletal Diseases
Cause of Death
Japan
Bone Density
Mortality
Knee Osteoarthritis
Knee
Cerebrovascular Disorders
Life Style
Body Mass Index
Cardiovascular Diseases
Multivariate Analysis
Odds Ratio
Survival

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Tsuboi, Masaki ; Hasegawa, Yukiharu ; Matsuyama, Yukihiro ; Suzuki, Sadao ; Suzuki, Koji ; Imagama, Shiro. / Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan?. In: Journal of Bone and Mineral Metabolism. 2011 ; Vol. 29, No. 2. pp. 217-223.
@article{39a0bd000b0840a6965088b0729b93d6,
title = "Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan?",
abstract = "There are several reports from Europe and the United States on mortality from musculoskeletal degenerative diseases; however, no reports have been published from Japan. This study is the first that has examined whether musculoskeletal degenerative diseases affect life prognosis in Japan. As many as 944 persons who were 60 years of age and older and who underwent one or more musculoskeletal checkups (knee, lower back, and bone mineral density examination) were enrolled. Survival and death after 10 years were examined. For each knee, lower back, and bone mineral density examination, subjects were divided into normal and abnormal groups. For each of the examinations (knee, lower back, or bone mineral density), 10-year mortality was compared between the two groups. Also, causes of death were examined after 10 years. As many as 805 subjects survived and 125 died. For those with and without osteoarthritis of the knee, mortality after 10 years was 17 and 10{\%}, respectively. For those with and without lower back abnormalities, mortality after 10 years was 12 and 14{\%}, respectively. For those with or without low bone mineral density, mortality after 10 years was 17 and 10{\%}, respectively. Multivariate analysis adjusted for age, gender, body mass index, and lifestyle revealed that odds ratio of death after 10 years was 2.32 and 2.33 in the presence of osteoarthritis of the knee and a low bone mineral density, respectively, and thus the risk of death after 10 years was significantly high. With regard to the cause of death, cerebrovascular and cardiovascular diseases were most frequently evident in patients with osteoarthritis of the knee. Musculoskeletal degenerative diseases influence mortality after 10 years.",
author = "Masaki Tsuboi and Yukiharu Hasegawa and Yukihiro Matsuyama and Sadao Suzuki and Koji Suzuki and Shiro Imagama",
year = "2011",
month = "3",
day = "1",
doi = "10.1007/s00774-010-0214-z",
language = "English",
volume = "29",
pages = "217--223",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",
number = "2",

}

Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan? / Tsuboi, Masaki; Hasegawa, Yukiharu; Matsuyama, Yukihiro; Suzuki, Sadao; Suzuki, Koji; Imagama, Shiro.

In: Journal of Bone and Mineral Metabolism, Vol. 29, No. 2, 01.03.2011, p. 217-223.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan?

AU - Tsuboi, Masaki

AU - Hasegawa, Yukiharu

AU - Matsuyama, Yukihiro

AU - Suzuki, Sadao

AU - Suzuki, Koji

AU - Imagama, Shiro

PY - 2011/3/1

Y1 - 2011/3/1

N2 - There are several reports from Europe and the United States on mortality from musculoskeletal degenerative diseases; however, no reports have been published from Japan. This study is the first that has examined whether musculoskeletal degenerative diseases affect life prognosis in Japan. As many as 944 persons who were 60 years of age and older and who underwent one or more musculoskeletal checkups (knee, lower back, and bone mineral density examination) were enrolled. Survival and death after 10 years were examined. For each knee, lower back, and bone mineral density examination, subjects were divided into normal and abnormal groups. For each of the examinations (knee, lower back, or bone mineral density), 10-year mortality was compared between the two groups. Also, causes of death were examined after 10 years. As many as 805 subjects survived and 125 died. For those with and without osteoarthritis of the knee, mortality after 10 years was 17 and 10%, respectively. For those with and without lower back abnormalities, mortality after 10 years was 12 and 14%, respectively. For those with or without low bone mineral density, mortality after 10 years was 17 and 10%, respectively. Multivariate analysis adjusted for age, gender, body mass index, and lifestyle revealed that odds ratio of death after 10 years was 2.32 and 2.33 in the presence of osteoarthritis of the knee and a low bone mineral density, respectively, and thus the risk of death after 10 years was significantly high. With regard to the cause of death, cerebrovascular and cardiovascular diseases were most frequently evident in patients with osteoarthritis of the knee. Musculoskeletal degenerative diseases influence mortality after 10 years.

AB - There are several reports from Europe and the United States on mortality from musculoskeletal degenerative diseases; however, no reports have been published from Japan. This study is the first that has examined whether musculoskeletal degenerative diseases affect life prognosis in Japan. As many as 944 persons who were 60 years of age and older and who underwent one or more musculoskeletal checkups (knee, lower back, and bone mineral density examination) were enrolled. Survival and death after 10 years were examined. For each knee, lower back, and bone mineral density examination, subjects were divided into normal and abnormal groups. For each of the examinations (knee, lower back, or bone mineral density), 10-year mortality was compared between the two groups. Also, causes of death were examined after 10 years. As many as 805 subjects survived and 125 died. For those with and without osteoarthritis of the knee, mortality after 10 years was 17 and 10%, respectively. For those with and without lower back abnormalities, mortality after 10 years was 12 and 14%, respectively. For those with or without low bone mineral density, mortality after 10 years was 17 and 10%, respectively. Multivariate analysis adjusted for age, gender, body mass index, and lifestyle revealed that odds ratio of death after 10 years was 2.32 and 2.33 in the presence of osteoarthritis of the knee and a low bone mineral density, respectively, and thus the risk of death after 10 years was significantly high. With regard to the cause of death, cerebrovascular and cardiovascular diseases were most frequently evident in patients with osteoarthritis of the knee. Musculoskeletal degenerative diseases influence mortality after 10 years.

UR - http://www.scopus.com/inward/record.url?scp=79959982639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959982639&partnerID=8YFLogxK

U2 - 10.1007/s00774-010-0214-z

DO - 10.1007/s00774-010-0214-z

M3 - Article

VL - 29

SP - 217

EP - 223

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 2

ER -