Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients

Nobuo Masumoto, Takuma Fujii, Mitsuya Ishikawa, Makio Mukai, Akiko Ono, Takashi Iwata, Kaneyuki Kubushiro, Shiro Nozawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective. Human papillomavirus (HPV) infection is reported to be related to carcinogenesis in the uterine cervix. In Japan, screening for cervical cancer by cytology is performed in women over 30 years old. The purpose of this study was to determine whether there is an association between patient age and cervical neoplasia or HPV infection in Japanese women. Methods. Specimens from 881 randomly selected patients who came to our clinic were tested for HPV DNA by using Hybrid Capture II, whereas specimens from a 204-patient randomly selected subset diagnosed with cervical neoplasia were tested for HPV DNA by using polymerase chain reaction (PCR). HPV typing was performed in all the PCR-positive cases. Results. The HPV-positive rate in the 20- to 29-year-old patients (29.0% in the normal cytology/histology group and 85.5% in the abnormal group) was higher than in the 30- to 59-year-old patients, and the rate declined until age 60 when age increased. While HPV 18, HPV 52, other HPV types, and HPV types as a whole were frequently detected in 30- to 49-year-old patients, HPV 16 was detected more frequently in the younger group than the other HPV types (P = 0.03). Among the HPV 16-positive patients with cervical neoplasia, the proportion of cervical intraepithelial neoplasia (CIN) 3 cases was high (44%) in the 20- to 29-year-old group. Conclusions. Screening for cervical neoplasia by cytology should also be performed in women under 30 years old in Japan. The HPV typing could be a tool to strictly follow-up younger women who were diagnosed with CIN.

Original languageEnglish
Pages (from-to)509-514
Number of pages6
JournalGynecologic Oncology
Volume94
Issue number2
DOIs
Publication statusPublished - 01-08-2004

Fingerprint

Papillomavirus Infections
Human papillomavirus 16
Outpatients
Neoplasms
Cell Biology
Cervical Intraepithelial Neoplasia
Japan
Human papillomavirus 18
Polymerase Chain Reaction
DNA-Directed DNA Polymerase
Cervix Uteri
Uterine Cervical Neoplasms
Histology
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Masumoto, Nobuo ; Fujii, Takuma ; Ishikawa, Mitsuya ; Mukai, Makio ; Ono, Akiko ; Iwata, Takashi ; Kubushiro, Kaneyuki ; Nozawa, Shiro. / Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients. In: Gynecologic Oncology. 2004 ; Vol. 94, No. 2. pp. 509-514.
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title = "Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients",
abstract = "Objective. Human papillomavirus (HPV) infection is reported to be related to carcinogenesis in the uterine cervix. In Japan, screening for cervical cancer by cytology is performed in women over 30 years old. The purpose of this study was to determine whether there is an association between patient age and cervical neoplasia or HPV infection in Japanese women. Methods. Specimens from 881 randomly selected patients who came to our clinic were tested for HPV DNA by using Hybrid Capture II, whereas specimens from a 204-patient randomly selected subset diagnosed with cervical neoplasia were tested for HPV DNA by using polymerase chain reaction (PCR). HPV typing was performed in all the PCR-positive cases. Results. The HPV-positive rate in the 20- to 29-year-old patients (29.0{\%} in the normal cytology/histology group and 85.5{\%} in the abnormal group) was higher than in the 30- to 59-year-old patients, and the rate declined until age 60 when age increased. While HPV 18, HPV 52, other HPV types, and HPV types as a whole were frequently detected in 30- to 49-year-old patients, HPV 16 was detected more frequently in the younger group than the other HPV types (P = 0.03). Among the HPV 16-positive patients with cervical neoplasia, the proportion of cervical intraepithelial neoplasia (CIN) 3 cases was high (44{\%}) in the 20- to 29-year-old group. Conclusions. Screening for cervical neoplasia by cytology should also be performed in women under 30 years old in Japan. The HPV typing could be a tool to strictly follow-up younger women who were diagnosed with CIN.",
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Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients. / Masumoto, Nobuo; Fujii, Takuma; Ishikawa, Mitsuya; Mukai, Makio; Ono, Akiko; Iwata, Takashi; Kubushiro, Kaneyuki; Nozawa, Shiro.

In: Gynecologic Oncology, Vol. 94, No. 2, 01.08.2004, p. 509-514.

Research output: Contribution to journalArticle

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T1 - Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients

AU - Masumoto, Nobuo

AU - Fujii, Takuma

AU - Ishikawa, Mitsuya

AU - Mukai, Makio

AU - Ono, Akiko

AU - Iwata, Takashi

AU - Kubushiro, Kaneyuki

AU - Nozawa, Shiro

PY - 2004/8/1

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N2 - Objective. Human papillomavirus (HPV) infection is reported to be related to carcinogenesis in the uterine cervix. In Japan, screening for cervical cancer by cytology is performed in women over 30 years old. The purpose of this study was to determine whether there is an association between patient age and cervical neoplasia or HPV infection in Japanese women. Methods. Specimens from 881 randomly selected patients who came to our clinic were tested for HPV DNA by using Hybrid Capture II, whereas specimens from a 204-patient randomly selected subset diagnosed with cervical neoplasia were tested for HPV DNA by using polymerase chain reaction (PCR). HPV typing was performed in all the PCR-positive cases. Results. The HPV-positive rate in the 20- to 29-year-old patients (29.0% in the normal cytology/histology group and 85.5% in the abnormal group) was higher than in the 30- to 59-year-old patients, and the rate declined until age 60 when age increased. While HPV 18, HPV 52, other HPV types, and HPV types as a whole were frequently detected in 30- to 49-year-old patients, HPV 16 was detected more frequently in the younger group than the other HPV types (P = 0.03). Among the HPV 16-positive patients with cervical neoplasia, the proportion of cervical intraepithelial neoplasia (CIN) 3 cases was high (44%) in the 20- to 29-year-old group. Conclusions. Screening for cervical neoplasia by cytology should also be performed in women under 30 years old in Japan. The HPV typing could be a tool to strictly follow-up younger women who were diagnosed with CIN.

AB - Objective. Human papillomavirus (HPV) infection is reported to be related to carcinogenesis in the uterine cervix. In Japan, screening for cervical cancer by cytology is performed in women over 30 years old. The purpose of this study was to determine whether there is an association between patient age and cervical neoplasia or HPV infection in Japanese women. Methods. Specimens from 881 randomly selected patients who came to our clinic were tested for HPV DNA by using Hybrid Capture II, whereas specimens from a 204-patient randomly selected subset diagnosed with cervical neoplasia were tested for HPV DNA by using polymerase chain reaction (PCR). HPV typing was performed in all the PCR-positive cases. Results. The HPV-positive rate in the 20- to 29-year-old patients (29.0% in the normal cytology/histology group and 85.5% in the abnormal group) was higher than in the 30- to 59-year-old patients, and the rate declined until age 60 when age increased. While HPV 18, HPV 52, other HPV types, and HPV types as a whole were frequently detected in 30- to 49-year-old patients, HPV 16 was detected more frequently in the younger group than the other HPV types (P = 0.03). Among the HPV 16-positive patients with cervical neoplasia, the proportion of cervical intraepithelial neoplasia (CIN) 3 cases was high (44%) in the 20- to 29-year-old group. Conclusions. Screening for cervical neoplasia by cytology should also be performed in women under 30 years old in Japan. The HPV typing could be a tool to strictly follow-up younger women who were diagnosed with CIN.

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