Abstract
To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.
| Original language | English |
|---|---|
| Pages (from-to) | 616-638 |
| Number of pages | 23 |
| Journal | CHEMOTHERAPY |
| Volume | 42 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1994 |
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Drug Discovery
- Oncology
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Double-blind study on SY 5555 in bacterial pneumonia. / Saito, Atsushi; Fukuhara, Hiroshi; Inadome, Jun; Irabu, Yuei; Shimoji, Katsuyoshi; Saito, Akira; Tomizawa, Masumi; Hiraga, Yohmei; Ohmichi, Mitsuhide; Sekine, Kyuichiro; Takabatake, Hirotsugu; Ito, Susumu; Kikuchi, Kohki; Yamamoto, Asako; Miura, Hiroshi; Kurokawa, Hirokazu; Honma, Mitsunobu; Miura, Shinichi; Onodera, Akihiko; Konishi, Kazuki; Tamura, Masashi; Takeuchi, Kenichi; Watanabe, Akira; Nukiwa, Toshihiro; Matsuda, Takashi; Arai, Hideo; Niizuma, Kazunao; Tanno, Yasuo; Shirato, Kunio; Sakamoto, Masahiro; Katsu, Masataka; Ohishi, Akira; Shibata, Masaru; Uzuka, Yoshio; Shimada, Kaoru; Oka, Shinichi; Sano, Yasuyuki; Miyamoto, Yasufumi; Arai, Yasuo; Shiba, Kohya; Yoshida, Masaki; Sakai, Osamu; Tanimoto, Hiroichi; Ohara, Kazuo; Okamura, Tetsuo; Saito, Atsushi; Nakata, Koichiro; Narui, Koji; Koyama, Masaru; Kobayashi, Hiroyuki; Kawai, Shin; Kudo, Koichiro; Sugiyama, Haruhito; Shishido, Harumi; Nagai, Hideaki; Irimajiri, Shoichiro; Matsuoka, Yasuo; Ohki, Eiji; Shimada, Jingoro; Hori, Seiji; Azuma, Takeshi; Momose, Shigeki; Sakata, Moromichi; Someya, Kazuhiko; Takahashi, Satoru; Nagayama, Yoshiaki; Sekita, Kohjiro; Takahashi, Masamitsu; Namiki, Masahiko; Ishizaka, Akitoshi; Matsumoto, Fumio; Imai, Takeo; Odagiri, Shigeki; Takahashi, Hiroshi; Watanabe, Koshiro; Kunigashira, Hideo; Wada, Koichi; Arakawa, Masaaki; Hoshino, Shigeyuki; Tsukada, Hiroki; Iwata, Fumihide; Aoki, Nobuki; Suzuki, Yasutoshi; Sekine, Osamu; Sato, Atsuhiko; Chida, Kingo; Hayakawa, Keishi; Imokawa, Shiro; Yagi, Takeshi; Suganuma, Hideki; Taniguchi, Masami; Iwata, Masatoshi; Ida, Masaaki; Kita, Tomoko; Nakano, Yutaka; Shichi, Izumi; Morita, Sumihito; Kawakatsu, Sumio; Yasuda, Kazumasa; Akiyama, Niichiro; Takizawa, Shigeo; Nakamura, Mikae; Shimokata, Kaoru; Ichiyama, Satoshi; Ogura, Yukio; Miyachi, Takuya; Sakai, Shuzo; Minami, Hironobu; Yamamoto, Masashi; Takagi, Eishi; Yurikusa, Naoko; Murate, Takanao; Ohno, Joji; Imaizumi, Kazuyoshi; Totani, Yasunobu; Kawatsu, Hidetaka; Miyaji, Haruyo; Takeuchi, Toshihiko; Yamada, Yasuo; Yamamoto, Kazuhide; Usami, Ikuji; Yamamoto, Toshiyuki; Suzuki, Kanzo; Matsuura, Toru; Yasunaga, Kojiro; Yonezu, Seibun; Yamanaka, Yoshitaka; Miki, Fumio; Narita, Nobuhiro; Sawaki, Masayoshi; Mikasa, Keiichi; Soejima, Rinzo; Niki, Yoshihito; Okimoto, Niro; Matsushima, Toshiharu; Kimura, Makoto; Yamakido, Michio; Inamizu, Jyun; Miyazawa, Teruomi; Kuwabara, Masao; Arita, Kenichi; Daido, Kazuhiro; Sasaki, Takao; Matsumoto, Yukio; Sugimoto, Yuji; Ueda, Nobuo; Kitade, Masahiro; Yoshida, Minoru; Nakanishi, Masayuki; Toyoshima, Hideo; Oizumi, Kotaro; Yano, Takafumi; Tanaka, Fumio; Mitsutake, Yoshiyuki; Kawahara, Masashi; Kawaguchi, Shinzo; Saisho, Masazumi; Shigematsu, Hironari; Ishibashi, Tsuneo; Takamoto, Masahiro; Kajiki, Akira; Ikeda, Akihito; Yamada, Hozumi; Kato, Osamu; Kuroki, Shigetaka; Yamaguchi, Masaya; Hara, Kohei; Kohno, Shigeru; Koga, Hironobu; Tomono, Kazunori; Kaku, Mitsuo; Watanabe, Koichi; Dotsu, Yasumasa; Mashimoto, Hideo; Inoue, Yuichi; Ohtsubo, Takakazu; Fujii, Tsuyoshi; Kawamura, Sumio; Matsumoto, Keizo; Akiyama, Moritoshi; Iwagaki, Akitaka; Ohishi, Kazunori; Takasugi, Masakazu; Nasu, Masaru; Goto, Yoichiro; Yamasaki, Tohru; Nagai, Hiroyuki; Goto, Jun; Kitagawa, Kazuo; Nagaoka, Hiroshi; Ando, Masayuki; Suga, Moritaka; Yamasaki, Kazuto; Fukuda, Yasutsugu; Tokunaga, Katsumasa; Nakagawa, Yoshihisa; Shimazu, Kazuyasu; Muranaka, Hiroyuki; Tamiya, Jiro; Sakata, Tetsunobu; Go, Yoshikatsu; Nishiura, Yuriko; Shima, Kiyoshi; Takenaka, Shinobu; Nakashima, Mitsuyoshi; Yamaguchi, Keizo; Hirakata, Yoichi; Kashitani, Fusako.
In: CHEMOTHERAPY, Vol. 42, No. 5, 1994, p. 616-638.Research output: Contribution to journal › Article
TY - JOUR
T1 - Double-blind study on SY 5555 in bacterial pneumonia
AU - Saito, Atsushi
AU - Fukuhara, Hiroshi
AU - Inadome, Jun
AU - Irabu, Yuei
AU - Shimoji, Katsuyoshi
AU - Saito, Akira
AU - Tomizawa, Masumi
AU - Hiraga, Yohmei
AU - Ohmichi, Mitsuhide
AU - Sekine, Kyuichiro
AU - Takabatake, Hirotsugu
AU - Ito, Susumu
AU - Kikuchi, Kohki
AU - Yamamoto, Asako
AU - Miura, Hiroshi
AU - Kurokawa, Hirokazu
AU - Honma, Mitsunobu
AU - Miura, Shinichi
AU - Onodera, Akihiko
AU - Konishi, Kazuki
AU - Tamura, Masashi
AU - Takeuchi, Kenichi
AU - Watanabe, Akira
AU - Nukiwa, Toshihiro
AU - Matsuda, Takashi
AU - Arai, Hideo
AU - Niizuma, Kazunao
AU - Tanno, Yasuo
AU - Shirato, Kunio
AU - Sakamoto, Masahiro
AU - Katsu, Masataka
AU - Ohishi, Akira
AU - Shibata, Masaru
AU - Uzuka, Yoshio
AU - Shimada, Kaoru
AU - Oka, Shinichi
AU - Sano, Yasuyuki
AU - Miyamoto, Yasufumi
AU - Arai, Yasuo
AU - Shiba, Kohya
AU - Yoshida, Masaki
AU - Sakai, Osamu
AU - Tanimoto, Hiroichi
AU - Ohara, Kazuo
AU - Okamura, Tetsuo
AU - Saito, Atsushi
AU - Nakata, Koichiro
AU - Narui, Koji
AU - Koyama, Masaru
AU - Kobayashi, Hiroyuki
AU - Kawai, Shin
AU - Kudo, Koichiro
AU - Sugiyama, Haruhito
AU - Shishido, Harumi
AU - Nagai, Hideaki
AU - Irimajiri, Shoichiro
AU - Matsuoka, Yasuo
AU - Ohki, Eiji
AU - Shimada, Jingoro
AU - Hori, Seiji
AU - Azuma, Takeshi
AU - Momose, Shigeki
AU - Sakata, Moromichi
AU - Someya, Kazuhiko
AU - Takahashi, Satoru
AU - Nagayama, Yoshiaki
AU - Sekita, Kohjiro
AU - Takahashi, Masamitsu
AU - Namiki, Masahiko
AU - Ishizaka, Akitoshi
AU - Matsumoto, Fumio
AU - Imai, Takeo
AU - Odagiri, Shigeki
AU - Takahashi, Hiroshi
AU - Watanabe, Koshiro
AU - Kunigashira, Hideo
AU - Wada, Koichi
AU - Arakawa, Masaaki
AU - Hoshino, Shigeyuki
AU - Tsukada, Hiroki
AU - Iwata, Fumihide
AU - Aoki, Nobuki
AU - Suzuki, Yasutoshi
AU - Sekine, Osamu
AU - Sato, Atsuhiko
AU - Chida, Kingo
AU - Hayakawa, Keishi
AU - Imokawa, Shiro
AU - Yagi, Takeshi
AU - Suganuma, Hideki
AU - Taniguchi, Masami
AU - Iwata, Masatoshi
AU - Ida, Masaaki
AU - Kita, Tomoko
AU - Nakano, Yutaka
AU - Shichi, Izumi
AU - Morita, Sumihito
AU - Kawakatsu, Sumio
AU - Yasuda, Kazumasa
AU - Akiyama, Niichiro
AU - Takizawa, Shigeo
AU - Nakamura, Mikae
AU - Shimokata, Kaoru
AU - Ichiyama, Satoshi
AU - Ogura, Yukio
AU - Miyachi, Takuya
AU - Sakai, Shuzo
AU - Minami, Hironobu
AU - Yamamoto, Masashi
AU - Takagi, Eishi
AU - Yurikusa, Naoko
AU - Murate, Takanao
AU - Ohno, Joji
AU - Imaizumi, Kazuyoshi
AU - Totani, Yasunobu
AU - Kawatsu, Hidetaka
AU - Miyaji, Haruyo
AU - Takeuchi, Toshihiko
AU - Yamada, Yasuo
AU - Yamamoto, Kazuhide
AU - Usami, Ikuji
AU - Yamamoto, Toshiyuki
AU - Suzuki, Kanzo
AU - Matsuura, Toru
AU - Yasunaga, Kojiro
AU - Yonezu, Seibun
AU - Yamanaka, Yoshitaka
AU - Miki, Fumio
AU - Narita, Nobuhiro
AU - Sawaki, Masayoshi
AU - Mikasa, Keiichi
AU - Soejima, Rinzo
AU - Niki, Yoshihito
AU - Okimoto, Niro
AU - Matsushima, Toshiharu
AU - Kimura, Makoto
AU - Yamakido, Michio
AU - Inamizu, Jyun
AU - Miyazawa, Teruomi
AU - Kuwabara, Masao
AU - Arita, Kenichi
AU - Daido, Kazuhiro
AU - Sasaki, Takao
AU - Matsumoto, Yukio
AU - Sugimoto, Yuji
AU - Ueda, Nobuo
AU - Kitade, Masahiro
AU - Yoshida, Minoru
AU - Nakanishi, Masayuki
AU - Toyoshima, Hideo
AU - Oizumi, Kotaro
AU - Yano, Takafumi
AU - Tanaka, Fumio
AU - Mitsutake, Yoshiyuki
AU - Kawahara, Masashi
AU - Kawaguchi, Shinzo
AU - Saisho, Masazumi
AU - Shigematsu, Hironari
AU - Ishibashi, Tsuneo
AU - Takamoto, Masahiro
AU - Kajiki, Akira
AU - Ikeda, Akihito
AU - Yamada, Hozumi
AU - Kato, Osamu
AU - Kuroki, Shigetaka
AU - Yamaguchi, Masaya
AU - Hara, Kohei
AU - Kohno, Shigeru
AU - Koga, Hironobu
AU - Tomono, Kazunori
AU - Kaku, Mitsuo
AU - Watanabe, Koichi
AU - Dotsu, Yasumasa
AU - Mashimoto, Hideo
AU - Inoue, Yuichi
AU - Ohtsubo, Takakazu
AU - Fujii, Tsuyoshi
AU - Kawamura, Sumio
AU - Matsumoto, Keizo
AU - Akiyama, Moritoshi
AU - Iwagaki, Akitaka
AU - Ohishi, Kazunori
AU - Takasugi, Masakazu
AU - Nasu, Masaru
AU - Goto, Yoichiro
AU - Yamasaki, Tohru
AU - Nagai, Hiroyuki
AU - Goto, Jun
AU - Kitagawa, Kazuo
AU - Nagaoka, Hiroshi
AU - Ando, Masayuki
AU - Suga, Moritaka
AU - Yamasaki, Kazuto
AU - Fukuda, Yasutsugu
AU - Tokunaga, Katsumasa
AU - Nakagawa, Yoshihisa
AU - Shimazu, Kazuyasu
AU - Muranaka, Hiroyuki
AU - Tamiya, Jiro
AU - Sakata, Tetsunobu
AU - Go, Yoshikatsu
AU - Nishiura, Yuriko
AU - Shima, Kiyoshi
AU - Takenaka, Shinobu
AU - Nakashima, Mitsuyoshi
AU - Yamaguchi, Keizo
AU - Hirakata, Yoichi
AU - Kashitani, Fusako
PY - 1994
Y1 - 1994
N2 - To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.
AB - To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.
UR - http://www.scopus.com/inward/record.url?scp=0028235428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028235428&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1953.42.616
DO - 10.11250/chemotherapy1953.42.616
M3 - Article
AN - SCOPUS:0028235428
VL - 42
SP - 616
EP - 638
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
SN - 0009-3165
IS - 5
ER -