Double-blind study on SY 5555 in bacterial pneumonia

Atsushi Saito; Hiroshi Fukuhara; Jun Inadome; Yuei Irabu; Katsuyoshi Shimoji; Akira Saito; Masumi Tomizawa; Yohmei Hiraga; Mitsuhide Ohmichi; Kyuichiro Sekine; Hirotsugu Takabatake; Susumu Ito; Kohki Kikuchi; Asako Yamamoto; Hiroshi Miura; Hirokazu Kurokawa; Mitsunobu Honma; Shinichi Miura; Akihiko Onodera; Kazuki Konishi; Masashi Tamura; Kenichi Takeuchi; Akira Watanabe; Toshihiro Nukiwa; Takashi Matsuda; Hideo Arai; Kazunao Niizuma; Yasuo Tanno; Kunio Shirato; Masahiro Sakamoto; Masataka Katsu; Akira Ohishi; Masaru Shibata; Yoshio Uzuka; Kaoru Shimada; Shinichi Oka; Yasuyuki Sano; Yasufumi Miyamoto; Yasuo Arai; Kohya Shiba; Masaki Yoshida; Osamu Sakai; Hiroichi Tanimoto; Kazuo Ohara; Tetsuo Okamura; Atsushi Saito; Koichiro Nakata; Koji Narui; Masaru Koyama; Hiroyuki Kobayashi; Shin Kawai; Koichiro Kudo; Haruhito Sugiyama; Harumi Shishido; Hideaki Nagai; Shoichiro Irimajiri; Yasuo Matsuoka; Eiji Ohki; Jingoro Shimada; Seiji Hori; Takeshi Azuma; Shigeki Momose; Moromichi Sakata; Kazuhiko Someya; Satoru Takahashi; Yoshiaki Nagayama; Kohjiro Sekita; Masamitsu Takahashi; Masahiko Namiki; Akitoshi Ishizaka; Fumio Matsumoto; Takeo Imai; Shigeki Odagiri; Hiroshi Takahashi; Koshiro Watanabe; Hideo Kunigashira; Koichi Wada; Masaaki Arakawa; Shigeyuki Hoshino; Hiroki Tsukada; Fumihide Iwata; Nobuki Aoki; Yasutoshi Suzuki; Osamu Sekine; Atsuhiko Sato; Kingo Chida; Keishi Hayakawa; Shiro Imokawa; Takeshi Yagi; Hideki Suganuma; Masami Taniguchi; Masatoshi Iwata; Masaaki Ida; Tomoko Kita; Yutaka Nakano; Izumi Shichi; Sumihito Morita; Sumio Kawakatsu; Kazumasa Yasuda; Niichiro Akiyama; Shigeo Takizawa; Mikae Nakamura; Kaoru Shimokata; Satoshi Ichiyama; Yukio Ogura; Takuya Miyachi; Shuzo Sakai; Hironobu Minami; Masashi Yamamoto; Eishi Takagi; Naoko Yurikusa; Takanao Murate; Joji Ohno; Kazuyoshi Imaizumi; Yasunobu Totani; Hidetaka Kawatsu; Haruyo Miyaji; Toshihiko Takeuchi; Yasuo Yamada; Kazuhide Yamamoto; Ikuji Usami; Toshiyuki Yamamoto; Kanzo Suzuki; Toru Matsuura; Kojiro Yasunaga; Seibun Yonezu; Yoshitaka Yamanaka; Fumio Miki; Nobuhiro Narita; Masayoshi Sawaki; Keiichi Mikasa; Rinzo Soejima; Yoshihito Niki; Niro Okimoto; Toshiharu Matsushima; Makoto Kimura; Michio Yamakido; Jyun Inamizu; Teruomi Miyazawa; Masao Kuwabara; Kenichi Arita; Kazuhiro Daido; Takao Sasaki; Yukio Matsumoto; Yuji Sugimoto; Nobuo Ueda; Masahiro Kitade; Minoru Yoshida; Masayuki Nakanishi; Hideo Toyoshima; Kotaro Oizumi; Takafumi Yano; Fumio Tanaka; Yoshiyuki Mitsutake; Masashi Kawahara; Shinzo Kawaguchi; Masazumi Saisho; Hironari Shigematsu; Tsuneo Ishibashi; Masahiro Takamoto; Akira Kajiki; Akihito Ikeda; Hozumi Yamada; Osamu Kato; Shigetaka Kuroki; Masaya Yamaguchi; Kohei Hara; Shigeru Kohno; Hironobu Koga; Kazunori Tomono; Mitsuo Kaku; Koichi Watanabe; Yasumasa Dotsu; Hideo Mashimoto; Yuichi Inoue; Takakazu Ohtsubo; Tsuyoshi Fujii; Sumio Kawamura; Keizo Matsumoto; Moritoshi Akiyama; Akitaka Iwagaki; Kazunori Ohishi; Masakazu Takasugi; Masaru Nasu; Yoichiro Goto; Tohru Yamasaki; Hiroyuki Nagai; Jun Goto; Kazuo Kitagawa; Hiroshi Nagaoka; Masayuki Ando; Moritaka Suga; Kazuto Yamasaki; Yasutsugu Fukuda; Katsumasa Tokunaga; Yoshihisa Nakagawa; Kazuyasu Shimazu; Hiroyuki Muranaka; Jiro Tamiya; Tetsunobu Sakata; Yoshikatsu Go; Yuriko Nishiura; Kiyoshi Shima; Shinobu Takenaka; Mitsuyoshi Nakashima; Keizo Yamaguchi; Yoichi Hirakata; Fusako Kashitani

doi:10.11250/chemotherapy1953.42.616

Double-blind study on SY 5555 in bacterial pneumonia

Atsushi Saito, Hiroshi Fukuhara, Jun Inadome, Yuei Irabu, Katsuyoshi Shimoji, Akira Saito, Masumi Tomizawa, Yohmei Hiraga, Mitsuhide Ohmichi, Kyuichiro Sekine, Hirotsugu Takabatake, Susumu Ito, Kohki Kikuchi, Asako Yamamoto, Hiroshi Miura, Hirokazu Kurokawa, Mitsunobu Honma, Shinichi Miura, Akihiko Onodera, Kazuki KonishiMasashi Tamura, Kenichi Takeuchi, Akira Watanabe, Toshihiro Nukiwa, Takashi Matsuda, Hideo Arai, Kazunao Niizuma, Yasuo Tanno, Kunio Shirato, Masahiro Sakamoto, Masataka Katsu, Akira Ohishi, Masaru Shibata, Yoshio Uzuka, Kaoru Shimada, Shinichi Oka, Yasuyuki Sano, Yasufumi Miyamoto, Yasuo Arai, Kohya Shiba, Masaki Yoshida, Osamu Sakai, Hiroichi Tanimoto, Kazuo Ohara, Tetsuo Okamura, Atsushi Saito, Koichiro Nakata, Koji Narui, Masaru Koyama, Hiroyuki Kobayashi, Shin Kawai, Koichiro Kudo, Haruhito Sugiyama, Harumi Shishido, Hideaki Nagai, Shoichiro Irimajiri, Yasuo Matsuoka, Eiji Ohki, Jingoro Shimada, Seiji Hori, Takeshi Azuma, Shigeki Momose, Moromichi Sakata, Kazuhiko Someya, Satoru Takahashi, Yoshiaki Nagayama, Kohjiro Sekita, Masamitsu Takahashi, Masahiko Namiki, Akitoshi Ishizaka, Fumio Matsumoto, Takeo Imai, Shigeki Odagiri, Hiroshi Takahashi, Koshiro Watanabe, Hideo Kunigashira, Koichi Wada, Masaaki Arakawa, Shigeyuki Hoshino, Hiroki Tsukada, Fumihide Iwata, Nobuki Aoki, Yasutoshi Suzuki, Osamu Sekine, Atsuhiko Sato, Kingo Chida, Keishi Hayakawa, Shiro Imokawa, Takeshi Yagi, Hideki Suganuma, Masami Taniguchi, Masatoshi Iwata, Masaaki Ida, Tomoko Kita, Yutaka Nakano, Izumi Shichi, Sumihito Morita, Sumio Kawakatsu, Kazumasa Yasuda, Niichiro Akiyama, Shigeo Takizawa, Mikae Nakamura, Kaoru Shimokata, Satoshi Ichiyama, Yukio Ogura, Takuya Miyachi, Shuzo Sakai, Hironobu Minami, Masashi Yamamoto, Eishi Takagi, Naoko Yurikusa, Takanao Murate, Joji Ohno, Kazuyoshi Imaizumi, Yasunobu Totani, Hidetaka Kawatsu, Haruyo Miyaji, Toshihiko Takeuchi, Yasuo Yamada, Kazuhide Yamamoto, Ikuji Usami, Toshiyuki Yamamoto, Kanzo Suzuki, Toru Matsuura, Kojiro Yasunaga, Seibun Yonezu, Yoshitaka Yamanaka, Fumio Miki, Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Rinzo Soejima, Yoshihito Niki, Niro Okimoto, Toshiharu Matsushima, Makoto Kimura, Michio Yamakido, Jyun Inamizu, Teruomi Miyazawa, Masao Kuwabara, Kenichi Arita, Kazuhiro Daido, Takao Sasaki, Yukio Matsumoto, Yuji Sugimoto, Nobuo Ueda, Masahiro Kitade, Minoru Yoshida, Masayuki Nakanishi, Hideo Toyoshima, Kotaro Oizumi, Takafumi Yano, Fumio Tanaka, Yoshiyuki Mitsutake, Masashi Kawahara, Shinzo Kawaguchi, Masazumi Saisho, Hironari Shigematsu, Tsuneo Ishibashi, Masahiro Takamoto, Akira Kajiki, Akihito Ikeda, Hozumi Yamada, Osamu Kato, Shigetaka Kuroki, Masaya Yamaguchi, Kohei Hara, Shigeru Kohno, Hironobu Koga, Kazunori Tomono, Mitsuo Kaku, Koichi Watanabe, Yasumasa Dotsu, Hideo Mashimoto, Yuichi Inoue, Takakazu Ohtsubo, Tsuyoshi Fujii, Sumio Kawamura, Keizo Matsumoto, Moritoshi Akiyama, Akitaka Iwagaki, Kazunori Ohishi, Masakazu Takasugi, Masaru Nasu, Yoichiro Goto, Tohru Yamasaki, Hiroyuki Nagai, Jun Goto, Kazuo Kitagawa, Hiroshi Nagaoka, Masayuki Ando, Moritaka Suga, Kazuto Yamasaki, Yasutsugu Fukuda, Katsumasa Tokunaga, Yoshihisa Nakagawa, Kazuyasu Shimazu, Hiroyuki Muranaka, Jiro Tamiya, Tetsunobu Sakata, Yoshikatsu Go, Yuriko Nishiura, Kiyoshi Shima, Shinobu Takenaka, Mitsuyoshi Nakashima, Keizo Yamaguchi, Yoichi Hirakata, Fusako Kashitani

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.

Original language	English
Pages (from-to)	616-638
Number of pages	23
Journal	CHEMOTHERAPY
Volume	42
Issue number	5
DOIs	https://doi.org/10.11250/chemotherapy1953.42.616
Publication status	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

Access to Document

10.11250/chemotherapy1953.42.616

Cite this

Saito, A., Fukuhara, H., Inadome, J., Irabu, Y., Shimoji, K., Saito, A., Tomizawa, M., Hiraga, Y., Ohmichi, M., Sekine, K., Takabatake, H., Ito, S., Kikuchi, K., Yamamoto, A., Miura, H., Kurokawa, H., Honma, M., Miura, S., Onodera, A., ... Kashitani, F. (1994). Double-blind study on SY 5555 in bacterial pneumonia. CHEMOTHERAPY, 42(5), 616-638. https://doi.org/10.11250/chemotherapy1953.42.616

Saito, Atsushi ; Fukuhara, Hiroshi ; Inadome, Jun ; Irabu, Yuei ; Shimoji, Katsuyoshi ; Saito, Akira ; Tomizawa, Masumi ; Hiraga, Yohmei ; Ohmichi, Mitsuhide ; Sekine, Kyuichiro ; Takabatake, Hirotsugu ; Ito, Susumu ; Kikuchi, Kohki ; Yamamoto, Asako ; Miura, Hiroshi ; Kurokawa, Hirokazu ; Honma, Mitsunobu ; Miura, Shinichi ; Onodera, Akihiko ; Konishi, Kazuki ; Tamura, Masashi ; Takeuchi, Kenichi ; Watanabe, Akira ; Nukiwa, Toshihiro ; Matsuda, Takashi ; Arai, Hideo ; Niizuma, Kazunao ; Tanno, Yasuo ; Shirato, Kunio ; Sakamoto, Masahiro ; Katsu, Masataka ; Ohishi, Akira ; Shibata, Masaru ; Uzuka, Yoshio ; Shimada, Kaoru ; Oka, Shinichi ; Sano, Yasuyuki ; Miyamoto, Yasufumi ; Arai, Yasuo ; Shiba, Kohya ; Yoshida, Masaki ; Sakai, Osamu ; Tanimoto, Hiroichi ; Ohara, Kazuo ; Okamura, Tetsuo ; Saito, Atsushi ; Nakata, Koichiro ; Narui, Koji ; Koyama, Masaru ; Kobayashi, Hiroyuki ; Kawai, Shin ; Kudo, Koichiro ; Sugiyama, Haruhito ; Shishido, Harumi ; Nagai, Hideaki ; Irimajiri, Shoichiro ; Matsuoka, Yasuo ; Ohki, Eiji ; Shimada, Jingoro ; Hori, Seiji ; Azuma, Takeshi ; Momose, Shigeki ; Sakata, Moromichi ; Someya, Kazuhiko ; Takahashi, Satoru ; Nagayama, Yoshiaki ; Sekita, Kohjiro ; Takahashi, Masamitsu ; Namiki, Masahiko ; Ishizaka, Akitoshi ; Matsumoto, Fumio ; Imai, Takeo ; Odagiri, Shigeki ; Takahashi, Hiroshi ; Watanabe, Koshiro ; Kunigashira, Hideo ; Wada, Koichi ; Arakawa, Masaaki ; Hoshino, Shigeyuki ; Tsukada, Hiroki ; Iwata, Fumihide ; Aoki, Nobuki ; Suzuki, Yasutoshi ; Sekine, Osamu ; Sato, Atsuhiko ; Chida, Kingo ; Hayakawa, Keishi ; Imokawa, Shiro ; Yagi, Takeshi ; Suganuma, Hideki ; Taniguchi, Masami ; Iwata, Masatoshi ; Ida, Masaaki ; Kita, Tomoko ; Nakano, Yutaka ; Shichi, Izumi ; Morita, Sumihito ; Kawakatsu, Sumio ; Yasuda, Kazumasa ; Akiyama, Niichiro ; Takizawa, Shigeo ; Nakamura, Mikae ; Shimokata, Kaoru ; Ichiyama, Satoshi ; Ogura, Yukio ; Miyachi, Takuya ; Sakai, Shuzo ; Minami, Hironobu ; Yamamoto, Masashi ; Takagi, Eishi ; Yurikusa, Naoko ; Murate, Takanao ; Ohno, Joji ; Imaizumi, Kazuyoshi ; Totani, Yasunobu ; Kawatsu, Hidetaka ; Miyaji, Haruyo ; Takeuchi, Toshihiko ; Yamada, Yasuo ; Yamamoto, Kazuhide ; Usami, Ikuji ; Yamamoto, Toshiyuki ; Suzuki, Kanzo ; Matsuura, Toru ; Yasunaga, Kojiro ; Yonezu, Seibun ; Yamanaka, Yoshitaka ; Miki, Fumio ; Narita, Nobuhiro ; Sawaki, Masayoshi ; Mikasa, Keiichi ; Soejima, Rinzo ; Niki, Yoshihito ; Okimoto, Niro ; Matsushima, Toshiharu ; Kimura, Makoto ; Yamakido, Michio ; Inamizu, Jyun ; Miyazawa, Teruomi ; Kuwabara, Masao ; Arita, Kenichi ; Daido, Kazuhiro ; Sasaki, Takao ; Matsumoto, Yukio ; Sugimoto, Yuji ; Ueda, Nobuo ; Kitade, Masahiro ; Yoshida, Minoru ; Nakanishi, Masayuki ; Toyoshima, Hideo ; Oizumi, Kotaro ; Yano, Takafumi ; Tanaka, Fumio ; Mitsutake, Yoshiyuki ; Kawahara, Masashi ; Kawaguchi, Shinzo ; Saisho, Masazumi ; Shigematsu, Hironari ; Ishibashi, Tsuneo ; Takamoto, Masahiro ; Kajiki, Akira ; Ikeda, Akihito ; Yamada, Hozumi ; Kato, Osamu ; Kuroki, Shigetaka ; Yamaguchi, Masaya ; Hara, Kohei ; Kohno, Shigeru ; Koga, Hironobu ; Tomono, Kazunori ; Kaku, Mitsuo ; Watanabe, Koichi ; Dotsu, Yasumasa ; Mashimoto, Hideo ; Inoue, Yuichi ; Ohtsubo, Takakazu ; Fujii, Tsuyoshi ; Kawamura, Sumio ; Matsumoto, Keizo ; Akiyama, Moritoshi ; Iwagaki, Akitaka ; Ohishi, Kazunori ; Takasugi, Masakazu ; Nasu, Masaru ; Goto, Yoichiro ; Yamasaki, Tohru ; Nagai, Hiroyuki ; Goto, Jun ; Kitagawa, Kazuo ; Nagaoka, Hiroshi ; Ando, Masayuki ; Suga, Moritaka ; Yamasaki, Kazuto ; Fukuda, Yasutsugu ; Tokunaga, Katsumasa ; Nakagawa, Yoshihisa ; Shimazu, Kazuyasu ; Muranaka, Hiroyuki ; Tamiya, Jiro ; Sakata, Tetsunobu ; Go, Yoshikatsu ; Nishiura, Yuriko ; Shima, Kiyoshi ; Takenaka, Shinobu ; Nakashima, Mitsuyoshi ; Yamaguchi, Keizo ; Hirakata, Yoichi ; Kashitani, Fusako. / Double-blind study on SY 5555 in bacterial pneumonia. In: CHEMOTHERAPY. 1994 ; Vol. 42, No. 5. pp. 616-638.

@article{85c3746b36ce49c882bb9becf8e613e1,

title = "Double-blind study on SY 5555 in bacterial pneumonia",

abstract = "To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.",

author = "Atsushi Saito and Hiroshi Fukuhara and Jun Inadome and Yuei Irabu and Katsuyoshi Shimoji and Akira Saito and Masumi Tomizawa and Yohmei Hiraga and Mitsuhide Ohmichi and Kyuichiro Sekine and Hirotsugu Takabatake and Susumu Ito and Kohki Kikuchi and Asako Yamamoto and Hiroshi Miura and Hirokazu Kurokawa and Mitsunobu Honma and Shinichi Miura and Akihiko Onodera and Kazuki Konishi and Masashi Tamura and Kenichi Takeuchi and Akira Watanabe and Toshihiro Nukiwa and Takashi Matsuda and Hideo Arai and Kazunao Niizuma and Yasuo Tanno and Kunio Shirato and Masahiro Sakamoto and Masataka Katsu and Akira Ohishi and Masaru Shibata and Yoshio Uzuka and Kaoru Shimada and Shinichi Oka and Yasuyuki Sano and Yasufumi Miyamoto and Yasuo Arai and Kohya Shiba and Masaki Yoshida and Osamu Sakai and Hiroichi Tanimoto and Kazuo Ohara and Tetsuo Okamura and Atsushi Saito and Koichiro Nakata and Koji Narui and Masaru Koyama and Hiroyuki Kobayashi and Shin Kawai and Koichiro Kudo and Haruhito Sugiyama and Harumi Shishido and Hideaki Nagai and Shoichiro Irimajiri and Yasuo Matsuoka and Eiji Ohki and Jingoro Shimada and Seiji Hori and Takeshi Azuma and Shigeki Momose and Moromichi Sakata and Kazuhiko Someya and Satoru Takahashi and Yoshiaki Nagayama and Kohjiro Sekita and Masamitsu Takahashi and Masahiko Namiki and Akitoshi Ishizaka and Fumio Matsumoto and Takeo Imai and Shigeki Odagiri and Hiroshi Takahashi and Koshiro Watanabe and Hideo Kunigashira and Koichi Wada and Masaaki Arakawa and Shigeyuki Hoshino and Hiroki Tsukada and Fumihide Iwata and Nobuki Aoki and Yasutoshi Suzuki and Osamu Sekine and Atsuhiko Sato and Kingo Chida and Keishi Hayakawa and Shiro Imokawa and Takeshi Yagi and Hideki Suganuma and Masami Taniguchi and Masatoshi Iwata and Masaaki Ida and Tomoko Kita and Yutaka Nakano and Izumi Shichi and Sumihito Morita and Sumio Kawakatsu and Kazumasa Yasuda and Niichiro Akiyama and Shigeo Takizawa and Mikae Nakamura and Kaoru Shimokata and Satoshi Ichiyama and Yukio Ogura and Takuya Miyachi and Shuzo Sakai and Hironobu Minami and Masashi Yamamoto and Eishi Takagi and Naoko Yurikusa and Takanao Murate and Joji Ohno and Kazuyoshi Imaizumi and Yasunobu Totani and Hidetaka Kawatsu and Haruyo Miyaji and Toshihiko Takeuchi and Yasuo Yamada and Kazuhide Yamamoto and Ikuji Usami and Toshiyuki Yamamoto and Kanzo Suzuki and Toru Matsuura and Kojiro Yasunaga and Seibun Yonezu and Yoshitaka Yamanaka and Fumio Miki and Nobuhiro Narita and Masayoshi Sawaki and Keiichi Mikasa and Rinzo Soejima and Yoshihito Niki and Niro Okimoto and Toshiharu Matsushima and Makoto Kimura and Michio Yamakido and Jyun Inamizu and Teruomi Miyazawa and Masao Kuwabara and Kenichi Arita and Kazuhiro Daido and Takao Sasaki and Yukio Matsumoto and Yuji Sugimoto and Nobuo Ueda and Masahiro Kitade and Minoru Yoshida and Masayuki Nakanishi and Hideo Toyoshima and Kotaro Oizumi and Takafumi Yano and Fumio Tanaka and Yoshiyuki Mitsutake and Masashi Kawahara and Shinzo Kawaguchi and Masazumi Saisho and Hironari Shigematsu and Tsuneo Ishibashi and Masahiro Takamoto and Akira Kajiki and Akihito Ikeda and Hozumi Yamada and Osamu Kato and Shigetaka Kuroki and Masaya Yamaguchi and Kohei Hara and Shigeru Kohno and Hironobu Koga and Kazunori Tomono and Mitsuo Kaku and Koichi Watanabe and Yasumasa Dotsu and Hideo Mashimoto and Yuichi Inoue and Takakazu Ohtsubo and Tsuyoshi Fujii and Sumio Kawamura and Keizo Matsumoto and Moritoshi Akiyama and Akitaka Iwagaki and Kazunori Ohishi and Masakazu Takasugi and Masaru Nasu and Yoichiro Goto and Tohru Yamasaki and Hiroyuki Nagai and Jun Goto and Kazuo Kitagawa and Hiroshi Nagaoka and Masayuki Ando and Moritaka Suga and Kazuto Yamasaki and Yasutsugu Fukuda and Katsumasa Tokunaga and Yoshihisa Nakagawa and Kazuyasu Shimazu and Hiroyuki Muranaka and Jiro Tamiya and Tetsunobu Sakata and Yoshikatsu Go and Yuriko Nishiura and Kiyoshi Shima and Shinobu Takenaka and Mitsuyoshi Nakashima and Keizo Yamaguchi and Yoichi Hirakata and Fusako Kashitani",

year = "1994",

doi = "10.11250/chemotherapy1953.42.616",

language = "English",

volume = "42",

pages = "616--638",

journal = "CHEMOTHERAPY",

issn = "0009-3165",

number = "5",

}

Saito, A, Fukuhara, H, Inadome, J, Irabu, Y, Shimoji, K, Saito, A, Tomizawa, M, Hiraga, Y, Ohmichi, M, Sekine, K, Takabatake, H, Ito, S, Kikuchi, K, Yamamoto, A, Miura, H, Kurokawa, H, Honma, M, Miura, S, Onodera, A, Konishi, K, Tamura, M, Takeuchi, K, Watanabe, A, Nukiwa, T, Matsuda, T, Arai, H, Niizuma, K, Tanno, Y, Shirato, K, Sakamoto, M, Katsu, M, Ohishi, A, Shibata, M, Uzuka, Y, Shimada, K, Oka, S, Sano, Y, Miyamoto, Y, Arai, Y, Shiba, K, Yoshida, M, Sakai, O, Tanimoto, H, Ohara, K, Okamura, T, Saito, A, Nakata, K, Narui, K, Koyama, M, Kobayashi, H, Kawai, S, Kudo, K, Sugiyama, H, Shishido, H, Nagai, H, Irimajiri, S, Matsuoka, Y, Ohki, E, Shimada, J, Hori, S, Azuma, T, Momose, S, Sakata, M, Someya, K, Takahashi, S, Nagayama, Y, Sekita, K, Takahashi, M, Namiki, M, Ishizaka, A, Matsumoto, F, Imai, T, Odagiri, S, Takahashi, H, Watanabe, K, Kunigashira, H, Wada, K, Arakawa, M, Hoshino, S, Tsukada, H, Iwata, F, Aoki, N, Suzuki, Y, Sekine, O, Sato, A, Chida, K, Hayakawa, K, Imokawa, S, Yagi, T, Suganuma, H, Taniguchi, M, Iwata, M, Ida, M, Kita, T, Nakano, Y, Shichi, I, Morita, S, Kawakatsu, S, Yasuda, K, Akiyama, N, Takizawa, S, Nakamura, M, Shimokata, K, Ichiyama, S, Ogura, Y, Miyachi, T, Sakai, S, Minami, H, Yamamoto, M, Takagi, E, Yurikusa, N, Murate, T, Ohno, J, Imaizumi, K, Totani, Y, Kawatsu, H, Miyaji, H, Takeuchi, T, Yamada, Y, Yamamoto, K, Usami, I, Yamamoto, T, Suzuki, K, Matsuura, T, Yasunaga, K, Yonezu, S, Yamanaka, Y, Miki, F, Narita, N, Sawaki, M, Mikasa, K, Soejima, R, Niki, Y, Okimoto, N, Matsushima, T, Kimura, M, Yamakido, M, Inamizu, J, Miyazawa, T, Kuwabara, M, Arita, K, Daido, K, Sasaki, T, Matsumoto, Y, Sugimoto, Y, Ueda, N, Kitade, M, Yoshida, M, Nakanishi, M, Toyoshima, H, Oizumi, K, Yano, T, Tanaka, F, Mitsutake, Y, Kawahara, M, Kawaguchi, S, Saisho, M, Shigematsu, H, Ishibashi, T, Takamoto, M, Kajiki, A, Ikeda, A, Yamada, H, Kato, O, Kuroki, S, Yamaguchi, M, Hara, K, Kohno, S, Koga, H, Tomono, K, Kaku, M, Watanabe, K, Dotsu, Y, Mashimoto, H, Inoue, Y, Ohtsubo, T, Fujii, T, Kawamura, S, Matsumoto, K, Akiyama, M, Iwagaki, A, Ohishi, K, Takasugi, M, Nasu, M, Goto, Y, Yamasaki, T, Nagai, H, Goto, J, Kitagawa, K, Nagaoka, H, Ando, M, Suga, M, Yamasaki, K, Fukuda, Y, Tokunaga, K, Nakagawa, Y, Shimazu, K, Muranaka, H, Tamiya, J, Sakata, T, Go, Y, Nishiura, Y, Shima, K, Takenaka, S, Nakashima, M, Yamaguchi, K, Hirakata, Y & Kashitani, F 1994, 'Double-blind study on SY 5555 in bacterial pneumonia', CHEMOTHERAPY, vol. 42, no. 5, pp. 616-638. https://doi.org/10.11250/chemotherapy1953.42.616

Double-blind study on SY 5555 in bacterial pneumonia. / Saito, Atsushi; Fukuhara, Hiroshi; Inadome, Jun; Irabu, Yuei; Shimoji, Katsuyoshi; Saito, Akira; Tomizawa, Masumi; Hiraga, Yohmei; Ohmichi, Mitsuhide; Sekine, Kyuichiro; Takabatake, Hirotsugu; Ito, Susumu; Kikuchi, Kohki; Yamamoto, Asako; Miura, Hiroshi; Kurokawa, Hirokazu; Honma, Mitsunobu; Miura, Shinichi; Onodera, Akihiko; Konishi, Kazuki; Tamura, Masashi; Takeuchi, Kenichi; Watanabe, Akira; Nukiwa, Toshihiro; Matsuda, Takashi; Arai, Hideo; Niizuma, Kazunao; Tanno, Yasuo; Shirato, Kunio; Sakamoto, Masahiro; Katsu, Masataka; Ohishi, Akira; Shibata, Masaru; Uzuka, Yoshio; Shimada, Kaoru; Oka, Shinichi; Sano, Yasuyuki; Miyamoto, Yasufumi; Arai, Yasuo; Shiba, Kohya; Yoshida, Masaki; Sakai, Osamu; Tanimoto, Hiroichi; Ohara, Kazuo; Okamura, Tetsuo; Saito, Atsushi; Nakata, Koichiro; Narui, Koji; Koyama, Masaru; Kobayashi, Hiroyuki; Kawai, Shin; Kudo, Koichiro; Sugiyama, Haruhito; Shishido, Harumi; Nagai, Hideaki; Irimajiri, Shoichiro; Matsuoka, Yasuo; Ohki, Eiji; Shimada, Jingoro; Hori, Seiji; Azuma, Takeshi; Momose, Shigeki; Sakata, Moromichi; Someya, Kazuhiko; Takahashi, Satoru; Nagayama, Yoshiaki; Sekita, Kohjiro; Takahashi, Masamitsu; Namiki, Masahiko; Ishizaka, Akitoshi; Matsumoto, Fumio; Imai, Takeo; Odagiri, Shigeki; Takahashi, Hiroshi; Watanabe, Koshiro; Kunigashira, Hideo; Wada, Koichi; Arakawa, Masaaki; Hoshino, Shigeyuki; Tsukada, Hiroki; Iwata, Fumihide; Aoki, Nobuki; Suzuki, Yasutoshi; Sekine, Osamu; Sato, Atsuhiko; Chida, Kingo; Hayakawa, Keishi; Imokawa, Shiro; Yagi, Takeshi; Suganuma, Hideki; Taniguchi, Masami; Iwata, Masatoshi; Ida, Masaaki; Kita, Tomoko; Nakano, Yutaka; Shichi, Izumi; Morita, Sumihito; Kawakatsu, Sumio; Yasuda, Kazumasa; Akiyama, Niichiro; Takizawa, Shigeo; Nakamura, Mikae; Shimokata, Kaoru; Ichiyama, Satoshi; Ogura, Yukio; Miyachi, Takuya; Sakai, Shuzo; Minami, Hironobu; Yamamoto, Masashi; Takagi, Eishi; Yurikusa, Naoko; Murate, Takanao; Ohno, Joji; Imaizumi, Kazuyoshi; Totani, Yasunobu; Kawatsu, Hidetaka; Miyaji, Haruyo; Takeuchi, Toshihiko; Yamada, Yasuo; Yamamoto, Kazuhide; Usami, Ikuji; Yamamoto, Toshiyuki; Suzuki, Kanzo; Matsuura, Toru; Yasunaga, Kojiro; Yonezu, Seibun; Yamanaka, Yoshitaka; Miki, Fumio; Narita, Nobuhiro; Sawaki, Masayoshi; Mikasa, Keiichi; Soejima, Rinzo; Niki, Yoshihito; Okimoto, Niro; Matsushima, Toshiharu; Kimura, Makoto; Yamakido, Michio; Inamizu, Jyun; Miyazawa, Teruomi; Kuwabara, Masao; Arita, Kenichi; Daido, Kazuhiro; Sasaki, Takao; Matsumoto, Yukio; Sugimoto, Yuji; Ueda, Nobuo; Kitade, Masahiro; Yoshida, Minoru; Nakanishi, Masayuki; Toyoshima, Hideo; Oizumi, Kotaro; Yano, Takafumi; Tanaka, Fumio; Mitsutake, Yoshiyuki; Kawahara, Masashi; Kawaguchi, Shinzo; Saisho, Masazumi; Shigematsu, Hironari; Ishibashi, Tsuneo; Takamoto, Masahiro; Kajiki, Akira; Ikeda, Akihito; Yamada, Hozumi; Kato, Osamu; Kuroki, Shigetaka; Yamaguchi, Masaya; Hara, Kohei; Kohno, Shigeru; Koga, Hironobu; Tomono, Kazunori; Kaku, Mitsuo; Watanabe, Koichi; Dotsu, Yasumasa; Mashimoto, Hideo; Inoue, Yuichi; Ohtsubo, Takakazu; Fujii, Tsuyoshi; Kawamura, Sumio; Matsumoto, Keizo; Akiyama, Moritoshi; Iwagaki, Akitaka; Ohishi, Kazunori; Takasugi, Masakazu; Nasu, Masaru; Goto, Yoichiro; Yamasaki, Tohru; Nagai, Hiroyuki; Goto, Jun; Kitagawa, Kazuo; Nagaoka, Hiroshi; Ando, Masayuki; Suga, Moritaka; Yamasaki, Kazuto; Fukuda, Yasutsugu; Tokunaga, Katsumasa; Nakagawa, Yoshihisa; Shimazu, Kazuyasu; Muranaka, Hiroyuki; Tamiya, Jiro; Sakata, Tetsunobu; Go, Yoshikatsu; Nishiura, Yuriko; Shima, Kiyoshi; Takenaka, Shinobu; Nakashima, Mitsuyoshi; Yamaguchi, Keizo; Hirakata, Yoichi; Kashitani, Fusako.

In: CHEMOTHERAPY, Vol. 42, No. 5, 1994, p. 616-638.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Double-blind study on SY 5555 in bacterial pneumonia

AU - Saito, Atsushi

AU - Fukuhara, Hiroshi

AU - Inadome, Jun

AU - Irabu, Yuei

AU - Shimoji, Katsuyoshi

AU - Saito, Akira

AU - Tomizawa, Masumi

AU - Hiraga, Yohmei

AU - Ohmichi, Mitsuhide

AU - Sekine, Kyuichiro

AU - Takabatake, Hirotsugu

AU - Ito, Susumu

AU - Kikuchi, Kohki

AU - Yamamoto, Asako

AU - Miura, Hiroshi

AU - Kurokawa, Hirokazu

AU - Honma, Mitsunobu

AU - Miura, Shinichi

AU - Onodera, Akihiko

AU - Konishi, Kazuki

AU - Tamura, Masashi

AU - Takeuchi, Kenichi

AU - Watanabe, Akira

AU - Nukiwa, Toshihiro

AU - Matsuda, Takashi

AU - Arai, Hideo

AU - Niizuma, Kazunao

AU - Tanno, Yasuo

AU - Shirato, Kunio

AU - Sakamoto, Masahiro

AU - Katsu, Masataka

AU - Ohishi, Akira

AU - Shibata, Masaru

AU - Uzuka, Yoshio

AU - Shimada, Kaoru

AU - Oka, Shinichi

AU - Sano, Yasuyuki

AU - Miyamoto, Yasufumi

AU - Arai, Yasuo

AU - Shiba, Kohya

AU - Yoshida, Masaki

AU - Sakai, Osamu

AU - Tanimoto, Hiroichi

AU - Ohara, Kazuo

AU - Okamura, Tetsuo

AU - Saito, Atsushi

AU - Nakata, Koichiro

AU - Narui, Koji

AU - Koyama, Masaru

AU - Kobayashi, Hiroyuki

AU - Kawai, Shin

AU - Kudo, Koichiro

AU - Sugiyama, Haruhito

AU - Shishido, Harumi

AU - Nagai, Hideaki

AU - Irimajiri, Shoichiro

AU - Matsuoka, Yasuo

AU - Ohki, Eiji

AU - Shimada, Jingoro

AU - Hori, Seiji

AU - Azuma, Takeshi

AU - Momose, Shigeki

AU - Sakata, Moromichi

AU - Someya, Kazuhiko

AU - Takahashi, Satoru

AU - Nagayama, Yoshiaki

AU - Sekita, Kohjiro

AU - Takahashi, Masamitsu

AU - Namiki, Masahiko

AU - Ishizaka, Akitoshi

AU - Matsumoto, Fumio

AU - Imai, Takeo

AU - Odagiri, Shigeki

AU - Takahashi, Hiroshi

AU - Watanabe, Koshiro

AU - Kunigashira, Hideo

AU - Wada, Koichi

AU - Arakawa, Masaaki

AU - Hoshino, Shigeyuki

AU - Tsukada, Hiroki

AU - Iwata, Fumihide

AU - Aoki, Nobuki

AU - Suzuki, Yasutoshi

AU - Sekine, Osamu

AU - Sato, Atsuhiko

AU - Chida, Kingo

AU - Hayakawa, Keishi

AU - Imokawa, Shiro

AU - Yagi, Takeshi

AU - Suganuma, Hideki

AU - Taniguchi, Masami

AU - Iwata, Masatoshi

AU - Ida, Masaaki

AU - Kita, Tomoko

AU - Nakano, Yutaka

AU - Shichi, Izumi

AU - Morita, Sumihito

AU - Kawakatsu, Sumio

AU - Yasuda, Kazumasa

AU - Akiyama, Niichiro

AU - Takizawa, Shigeo

AU - Nakamura, Mikae

AU - Shimokata, Kaoru

AU - Ichiyama, Satoshi

AU - Ogura, Yukio

AU - Miyachi, Takuya

AU - Sakai, Shuzo

AU - Minami, Hironobu

AU - Yamamoto, Masashi

AU - Takagi, Eishi

AU - Yurikusa, Naoko

AU - Murate, Takanao

AU - Ohno, Joji

AU - Imaizumi, Kazuyoshi

AU - Totani, Yasunobu

AU - Kawatsu, Hidetaka

AU - Miyaji, Haruyo

AU - Takeuchi, Toshihiko

AU - Yamada, Yasuo

AU - Yamamoto, Kazuhide

AU - Usami, Ikuji

AU - Yamamoto, Toshiyuki

AU - Suzuki, Kanzo

AU - Matsuura, Toru

AU - Yasunaga, Kojiro

AU - Yonezu, Seibun

AU - Yamanaka, Yoshitaka

AU - Miki, Fumio

AU - Narita, Nobuhiro

AU - Sawaki, Masayoshi

AU - Mikasa, Keiichi

AU - Soejima, Rinzo

AU - Niki, Yoshihito

AU - Okimoto, Niro

AU - Matsushima, Toshiharu

AU - Kimura, Makoto

AU - Yamakido, Michio

AU - Inamizu, Jyun

AU - Miyazawa, Teruomi

AU - Kuwabara, Masao

AU - Arita, Kenichi

AU - Daido, Kazuhiro

AU - Sasaki, Takao

AU - Matsumoto, Yukio

AU - Sugimoto, Yuji

AU - Ueda, Nobuo

AU - Kitade, Masahiro

AU - Yoshida, Minoru

AU - Nakanishi, Masayuki

AU - Toyoshima, Hideo

AU - Oizumi, Kotaro

AU - Yano, Takafumi

AU - Tanaka, Fumio

AU - Mitsutake, Yoshiyuki

AU - Kawahara, Masashi

AU - Kawaguchi, Shinzo

AU - Saisho, Masazumi

AU - Shigematsu, Hironari

AU - Ishibashi, Tsuneo

AU - Takamoto, Masahiro

AU - Kajiki, Akira

AU - Ikeda, Akihito

AU - Yamada, Hozumi

AU - Kato, Osamu

AU - Kuroki, Shigetaka

AU - Yamaguchi, Masaya

AU - Hara, Kohei

AU - Kohno, Shigeru

AU - Koga, Hironobu

AU - Tomono, Kazunori

AU - Kaku, Mitsuo

AU - Watanabe, Koichi

AU - Dotsu, Yasumasa

AU - Mashimoto, Hideo

AU - Inoue, Yuichi

AU - Ohtsubo, Takakazu

AU - Fujii, Tsuyoshi

AU - Kawamura, Sumio

AU - Matsumoto, Keizo

AU - Akiyama, Moritoshi

AU - Iwagaki, Akitaka

AU - Ohishi, Kazunori

AU - Takasugi, Masakazu

AU - Nasu, Masaru

AU - Goto, Yoichiro

AU - Yamasaki, Tohru

AU - Nagai, Hiroyuki

AU - Goto, Jun

AU - Kitagawa, Kazuo

AU - Nagaoka, Hiroshi

AU - Ando, Masayuki

AU - Suga, Moritaka

AU - Yamasaki, Kazuto

AU - Fukuda, Yasutsugu

AU - Tokunaga, Katsumasa

AU - Nakagawa, Yoshihisa

AU - Shimazu, Kazuyasu

AU - Muranaka, Hiroyuki

AU - Tamiya, Jiro

AU - Sakata, Tetsunobu

AU - Go, Yoshikatsu

AU - Nishiura, Yuriko

AU - Shima, Kiyoshi

AU - Takenaka, Shinobu

AU - Nakashima, Mitsuyoshi

AU - Yamaguchi, Keizo

AU - Hirakata, Yoichi

AU - Kashitani, Fusako

PY - 1994

Y1 - 1994

N2 - To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.

AB - To evaluate the clinical usefulness of SY 5555, a new oral penem, in the treatment of bacterial pneumonia, a double-blind comparative study, using cefotiam hexetil (CTM-HE) as the control drug, was conducted in various clinical institutes. The drugs were given at a daily dose of 900 mg of SY 5555 or 600 mg of CTM-HE, divided three times a day, for 14 days. 1. The clinical efficacy rates were 90.2% (83/92) for the SY 5555 group and 85.1% (86/101) for the CTM-HE group. The efficacy rates of the two drugs were not significantly different. 2. Bacteriologically, the eradication rates were 77.4%(24/31) for the SY 5555 group and 89.2% (33/37) for the CTM-HE group, showing no statisticaly significant difference between them. 3. Side effects were observed 8 of 111 patients in the SY 5555 group and 7 of 111 patients in the CTM-HE group. The main side effect was gastrointestinal symptoms in both groups. 4. The incidence of abnormal changes in laboratory findings was 19.6% (21/107) in the SY 5555 group and 16.8% (18/107) in the CTM-HE group. 5. The total usefulness rates were 88.3% (83/94) in the SY 5555 group and 81.4% (83/102) in the CTM-HE group. There was no significant difference between the two groups. The above results showed that in terms of efficacy and safety the SY 5555 group was equal to the CTM-HE group. SY 5555 was concluded to be a useful drug for the treatment of bacterial pneumonia.

UR - http://www.scopus.com/inward/record.url?scp=0028235428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028235428&partnerID=8YFLogxK

U2 - 10.11250/chemotherapy1953.42.616

DO - 10.11250/chemotherapy1953.42.616

M3 - Article

AN - SCOPUS:0028235428

VL - 42

SP - 616

EP - 638

JO - CHEMOTHERAPY

JF - CHEMOTHERAPY

SN - 0009-3165

IS - 5

ER -

Double-blind study on SY 5555 in bacterial pneumonia

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