Drug addiction research using intravenous self-administration procedure in mice

Takenao Koseki, Toshitaka Nabeshima

Research output: Contribution to journalReview article

Abstract

A major clinical problem in treating drug abusers or addicts is the high rate of relapse to abuse even long after abstinence. In drug dependence research, drug self-administration displays excellent face validity, good construct validity, and appealing predictive validity with respect to drug consumption in humans. Because of the technical feasibility of intravenous drug self-administration, it is limited in mice relative to larger animals. Nevertheless, technical innovations made in the last 10 years have vastly improved the feasibility of long-term studies in mice. In addition, mice with targeted gene mutations, such as transgenic and knockout mice, provide a powerful tool for investigating candidate genes that may be involved in abuse of drugs in humans. Therefore, it is essential for researchers to extend the extinction-reinstatement procedure in mice. However, there are few reports that proven the relationship between genetic factor and relapsing behavior using drug self-administration procedure in mice. Based on recent documented information and our own experiences, in the present review, we described some procedural considerations for the successful establishment of drug self-administration procedure in mice, and then summarized some behavioral characteristics of genetic mouse models under the drug self-administration, and reinstatement procedure.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalNihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence
Volume45
Issue number3
Publication statusPublished - 01-06-2010
Externally publishedYes

Fingerprint

self-administration
Self Administration
drug dependence
Intravenous Administration
Substance-Related Disorders
drug
Research
Pharmaceutical Preparations
Drug Users
abuse
Behavioral Genetics
Genetic Models
heredity
relapse
Reproducibility of Results
Knockout Mice
Transgenic Mice
Genes
construct validity
technical innovation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health(social science)

Cite this

@article{989544f532e54b90be4aea5f220ac029,
title = "Drug addiction research using intravenous self-administration procedure in mice",
abstract = "A major clinical problem in treating drug abusers or addicts is the high rate of relapse to abuse even long after abstinence. In drug dependence research, drug self-administration displays excellent face validity, good construct validity, and appealing predictive validity with respect to drug consumption in humans. Because of the technical feasibility of intravenous drug self-administration, it is limited in mice relative to larger animals. Nevertheless, technical innovations made in the last 10 years have vastly improved the feasibility of long-term studies in mice. In addition, mice with targeted gene mutations, such as transgenic and knockout mice, provide a powerful tool for investigating candidate genes that may be involved in abuse of drugs in humans. Therefore, it is essential for researchers to extend the extinction-reinstatement procedure in mice. However, there are few reports that proven the relationship between genetic factor and relapsing behavior using drug self-administration procedure in mice. Based on recent documented information and our own experiences, in the present review, we described some procedural considerations for the successful establishment of drug self-administration procedure in mice, and then summarized some behavioral characteristics of genetic mouse models under the drug self-administration, and reinstatement procedure.",
author = "Takenao Koseki and Toshitaka Nabeshima",
year = "2010",
month = "6",
day = "1",
language = "English",
volume = "45",
pages = "147--156",
journal = "Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence",
issn = "1341-8963",
publisher = "Nihon Arukoru Igakkai/Japenese Medical Society of Alcohol Studies",
number = "3",

}

TY - JOUR

T1 - Drug addiction research using intravenous self-administration procedure in mice

AU - Koseki, Takenao

AU - Nabeshima, Toshitaka

PY - 2010/6/1

Y1 - 2010/6/1

N2 - A major clinical problem in treating drug abusers or addicts is the high rate of relapse to abuse even long after abstinence. In drug dependence research, drug self-administration displays excellent face validity, good construct validity, and appealing predictive validity with respect to drug consumption in humans. Because of the technical feasibility of intravenous drug self-administration, it is limited in mice relative to larger animals. Nevertheless, technical innovations made in the last 10 years have vastly improved the feasibility of long-term studies in mice. In addition, mice with targeted gene mutations, such as transgenic and knockout mice, provide a powerful tool for investigating candidate genes that may be involved in abuse of drugs in humans. Therefore, it is essential for researchers to extend the extinction-reinstatement procedure in mice. However, there are few reports that proven the relationship between genetic factor and relapsing behavior using drug self-administration procedure in mice. Based on recent documented information and our own experiences, in the present review, we described some procedural considerations for the successful establishment of drug self-administration procedure in mice, and then summarized some behavioral characteristics of genetic mouse models under the drug self-administration, and reinstatement procedure.

AB - A major clinical problem in treating drug abusers or addicts is the high rate of relapse to abuse even long after abstinence. In drug dependence research, drug self-administration displays excellent face validity, good construct validity, and appealing predictive validity with respect to drug consumption in humans. Because of the technical feasibility of intravenous drug self-administration, it is limited in mice relative to larger animals. Nevertheless, technical innovations made in the last 10 years have vastly improved the feasibility of long-term studies in mice. In addition, mice with targeted gene mutations, such as transgenic and knockout mice, provide a powerful tool for investigating candidate genes that may be involved in abuse of drugs in humans. Therefore, it is essential for researchers to extend the extinction-reinstatement procedure in mice. However, there are few reports that proven the relationship between genetic factor and relapsing behavior using drug self-administration procedure in mice. Based on recent documented information and our own experiences, in the present review, we described some procedural considerations for the successful establishment of drug self-administration procedure in mice, and then summarized some behavioral characteristics of genetic mouse models under the drug self-administration, and reinstatement procedure.

UR - http://www.scopus.com/inward/record.url?scp=77956996619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956996619&partnerID=8YFLogxK

M3 - Review article

VL - 45

SP - 147

EP - 156

JO - Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

JF - Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

SN - 1341-8963

IS - 3

ER -