Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7

Akiko Yagami, Tetsushi Yoshikawa, Yoshizo Asano, Shin Koie, Tetsuo Shiohara, Kayoko Matsunaga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It has been suggested that reactivation of human herpesvirus 6 (HHV-6) infection may be involved in the pathogenesis of drug-induced hypersensitivity syndrome. We report a 45-year-old Japanese man who developed a generalized papuloerythematous rash, fever, hepatitis, lymphadenopathy and lymphocytosis with an increased number of atypical lymphocytes. He was diagnosed with DIHS due to mexiletine hydrochloride based on laboratory data, results of a patch test and the clinical course of his complaint, and was treated with systemic steroids. In order to determine whether HHV-6 or -7 was associated with the patient's disease, serological assays and PCR were carried out. Significant increases in antibody titers against HHV-6 and -7 were observed from day 12 to 24. From PCR analysis, none of the peripheral blood mononuclear cells or skin tissue samples contained HHV-6 DNA. All samples, however, were found to contain HHV-7 DNA. Reactivation of HHV-7 could be responsible for drug-induced hypersensitivity syndrome.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalDermatology
Volume213
Issue number4
DOIs
Publication statusPublished - 01-11-2006

Fingerprint

Human Herpesvirus 7
Drug Hypersensitivity Syndrome
Mexiletine
Human Herpesvirus 6
Herpesviridae Infections
Lymphocytosis
Polymerase Chain Reaction
Patch Tests
DNA
Lymphocyte Count
Exanthema
Hepatitis
Blood Cells
Fever
Steroids
Skin
Antibodies

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Yagami, Akiko ; Yoshikawa, Tetsushi ; Asano, Yoshizo ; Koie, Shin ; Shiohara, Tetsuo ; Matsunaga, Kayoko. / Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7. In: Dermatology. 2006 ; Vol. 213, No. 4. pp. 341-344.
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Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7. / Yagami, Akiko; Yoshikawa, Tetsushi; Asano, Yoshizo; Koie, Shin; Shiohara, Tetsuo; Matsunaga, Kayoko.

In: Dermatology, Vol. 213, No. 4, 01.11.2006, p. 341-344.

Research output: Contribution to journalArticle

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