Abstract
Fas and single stranded DNA (ssDNA) are markers of cell apoptosis. We used immunohistochemical methods to locate the presence of Fas and ssDNA in surgically obtained lens epithelial cells. One specimen was from atopic cataract with pyramidal opacity in the anterior pole in a 22-year-old male. The other was a fibrous opacity along the margin of anterior capsulotomy in a 65-year-old female who had received cataract surgery with intraocular lens implantation 6 years before. In the case of anterior polar cataract, both Fas and ssDNA were positive in the multilayered lens epithelial cells. In the case of secondary cataract with fibrous opacity, Fas was negative and ssDNA was positive in the stratified lens epithelial cells. The finding seemed to show that apoptosis may have occurred through a route bypassing Fas in the fibrous opacity along the margin of anterior capsular capsulotomy.
| Original language | English |
|---|---|
| Pages (from-to) | 347-351 |
| Number of pages | 5 |
| Journal | Japanese Journal of Clinical Ophthalmology |
| Volume | 55 |
| Issue number | 3 |
| Publication status | Published - 01-01-2001 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
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Duplication of lens epithelial cells and apoptosis. / Majima, K.; Kiribuchi, K.; Itonaga, K.; Yamamoto, N.
In: Japanese Journal of Clinical Ophthalmology, Vol. 55, No. 3, 01.01.2001, p. 347-351.Research output: Contribution to journal › Article
TY - JOUR
T1 - Duplication of lens epithelial cells and apoptosis
AU - Majima, K.
AU - Kiribuchi, K.
AU - Itonaga, K.
AU - Yamamoto, N.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Fas and single stranded DNA (ssDNA) are markers of cell apoptosis. We used immunohistochemical methods to locate the presence of Fas and ssDNA in surgically obtained lens epithelial cells. One specimen was from atopic cataract with pyramidal opacity in the anterior pole in a 22-year-old male. The other was a fibrous opacity along the margin of anterior capsulotomy in a 65-year-old female who had received cataract surgery with intraocular lens implantation 6 years before. In the case of anterior polar cataract, both Fas and ssDNA were positive in the multilayered lens epithelial cells. In the case of secondary cataract with fibrous opacity, Fas was negative and ssDNA was positive in the stratified lens epithelial cells. The finding seemed to show that apoptosis may have occurred through a route bypassing Fas in the fibrous opacity along the margin of anterior capsular capsulotomy.
AB - Fas and single stranded DNA (ssDNA) are markers of cell apoptosis. We used immunohistochemical methods to locate the presence of Fas and ssDNA in surgically obtained lens epithelial cells. One specimen was from atopic cataract with pyramidal opacity in the anterior pole in a 22-year-old male. The other was a fibrous opacity along the margin of anterior capsulotomy in a 65-year-old female who had received cataract surgery with intraocular lens implantation 6 years before. In the case of anterior polar cataract, both Fas and ssDNA were positive in the multilayered lens epithelial cells. In the case of secondary cataract with fibrous opacity, Fas was negative and ssDNA was positive in the stratified lens epithelial cells. The finding seemed to show that apoptosis may have occurred through a route bypassing Fas in the fibrous opacity along the margin of anterior capsular capsulotomy.
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M3 - Article
VL - 55
SP - 347
EP - 351
JO - Japanese Journal of Clinical Ophthalmology
JF - Japanese Journal of Clinical Ophthalmology
SN - 0370-5579
IS - 3
ER -