Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Akiko Okuda, Tatsuyo Suzuki, Taro Kishi, Yoshio Yamanouchi, Kazunori Umeda, Hiroshi Haitoh, Shuji Hashimoto, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Aims: The aim of this study was to analyze the relation between treatment response and the duration of untreated illness (DUI) in 133 outpatients with the first major depressive disorder (MDD) episode. Methods: A logistic regression was performed with DUI, sex, age at onset, and score for 17 items on the Hamilton Depression Rating Scale at the time of start of fluvoxamine treatment as the explanatory variables, and the response and the remission as the outcome variables. Results: Regression analysis showed significant association between the response and DUI (P < 0.0001), and between the remission and DUI (P < 0.0001), respectively. The remission rate gradually decreased with longer DUI. Conclusion: Early treatment of first depressive episodes is important because a shorter DUI implied better remission outcomes.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalPsychiatry and clinical neurosciences
Volume64
Issue number3
DOIs
Publication statusPublished - 06-2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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