Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Akiko Okuda; Tatsuyo Suzuki; Taro Kishi; Yoshio Yamanouchi; Kazunori Umeda; Hiroshi Haitoh; Shuji Hashimoto; Norio Ozaki; Nakao Iwata

doi:10.1111/j.1440-1819.2010.02091.x

Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Akiko Okuda
, Tatsuyo Suzuki
, Taro Kishi
, Yoshio Yamanouchi
, Kazunori Umeda
, Hiroshi Haitoh
, Shuji Hashimoto
, Norio Ozaki
, Nakao Iwata

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Aims: The aim of this study was to analyze the relation between treatment response and the duration of untreated illness (DUI) in 133 outpatients with the first major depressive disorder (MDD) episode. Methods: A logistic regression was performed with DUI, sex, age at onset, and score for 17 items on the Hamilton Depression Rating Scale at the time of start of fluvoxamine treatment as the explanatory variables, and the response and the remission as the outcome variables. Results: Regression analysis showed significant association between the response and DUI (P < 0.0001), and between the remission and DUI (P < 0.0001), respectively. The remission rate gradually decreased with longer DUI. Conclusion: Early treatment of first depressive episodes is important because a shorter DUI implied better remission outcomes.

Original language	English
Pages (from-to)	268-273
Number of pages	6
Journal	Psychiatry and clinical neurosciences
Volume	64
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1819.2010.02091.x
Publication status	Published - 06-2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Neuroscience
Neurology
Clinical Neurology
Psychiatry and Mental health

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10.1111/j.1440-1819.2010.02091.x

Cite this

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AU - Okuda, Akiko

AU - Suzuki, Tatsuyo

AU - Kishi, Taro

AU - Yamanouchi, Yoshio

AU - Umeda, Kazunori

AU - Haitoh, Hiroshi

AU - Hashimoto, Shuji

AU - Ozaki, Norio

AU - Iwata, Nakao

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Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Abstract

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