Dynamic acquisition with a three-headed SPECT system: Application to technetium 99m-SQ30217 myocardial imaging

K. Nakajima, J. Taki, H. Bunko, M. Matsudaira, A. Muramori, I. Matsunari, K. Hisada, T. Ichihara

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36 Citations (Scopus)

Abstract

A method for SPECT data acquisition, 'continuous repetitive rotation acquisition,' was developed with a high-sensitivity three-headed SPECT system. The method was applied to the dynamic imaging of 99mTc-SQ30217, a new myocardial imaging agent. After acquisition and reconstruction of SPECT data every minute, projection images at arbitrary intervals were used for tomographic reconstruction to determine the best timing of SPECT imaging in 99mTc-SQ30217. Based on a comparison of several possible acquisition intervals, SPECT data acquisition within 9 min after injection is recommended because of high myocardial uptake (myocardium-to-lung ratio, 2.83 ± 0.42 (mean ± s.e.m.) at 3-6 min) and relatively low hepatic uptake (myocardium-to-liver ratio, 0.85 ± 0.13 at 3-6 min). The rate constant of the clearance of 99mTc-SQ30217 from the myocardium obtained by SPECT was: k1 = 0.249 ± 0.050 per min (average half-life = 2.8 min) and k2 = 0.012 ± 0.004/min (average half-life = 58 min). The continuous repetitive rotation acquisition SPECT study appears useful for imaging SQ30217 with its rapidly changing myocardial distribution.

Original languageEnglish
Pages (from-to)1273-1277
Number of pages5
JournalJournal of Nuclear Medicine
Volume32
Issue number6
Publication statusPublished - 01-01-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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