Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy

Yasushi Takeichi, Kohzo Nagata, Hideo Izawa, Mitsunori Iwase, Toshikazu Sobue, Motoaki Sugawara, Mitsuhiro Yokota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated the effect of mild exercise on global and regional diastolic function in patients with hypertensive left ventricular hypertrophy (LVH), using simultaneous measurement of micromanometric left ventricular pressure and echocardiographic indexes. Although left ventricular end-diastolic pressure (LVEDP) at rest in the hypertensive LVH group was similar to that in the control normotensive group, who had no abnormality on echocardiography or cardiac catheterization, LVEDP showed a marked increase during exercise only in the hypertensive LVH group. The pressure-dimension relation was shifted upward during exercise in all patients with hypertensive LVH. We utilized a new index of regional diastolic myocardial stiffness, KDM, which is derived from the diastolic relation between the mean wall stress and the natural logarithm of the reciprocal of wall thickness. Although KDM at rest was similar in the two groups, KDM increased significantly during exercise, both in the septum and posterior wall in patients with hypertensive LVH. The present results imply that even low-grade exercise may have deleterious effects on regional myocardial performance in patients with hypertensive LVH.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalHeart and Vessels
Volume12
Issue numberSUPPL. 12
Publication statusPublished - 01-12-1997
Externally publishedYes

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Left Ventricular Hypertrophy
Myocardium
Exercise
Blood Pressure
Ventricular Pressure
Cardiac Catheterization
Echocardiography
Pressure
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Takeichi, Y., Nagata, K., Izawa, H., Iwase, M., Sobue, T., Sugawara, M., & Yokota, M. (1997). Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy. Heart and Vessels, 12(SUPPL. 12), 138-141.
Takeichi, Yasushi ; Nagata, Kohzo ; Izawa, Hideo ; Iwase, Mitsunori ; Sobue, Toshikazu ; Sugawara, Motoaki ; Yokota, Mitsuhiro. / Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy. In: Heart and Vessels. 1997 ; Vol. 12, No. SUPPL. 12. pp. 138-141.
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Takeichi, Y, Nagata, K, Izawa, H, Iwase, M, Sobue, T, Sugawara, M & Yokota, M 1997, 'Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy', Heart and Vessels, vol. 12, no. SUPPL. 12, pp. 138-141.

Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy. / Takeichi, Yasushi; Nagata, Kohzo; Izawa, Hideo; Iwase, Mitsunori; Sobue, Toshikazu; Sugawara, Motoaki; Yokota, Mitsuhiro.

In: Heart and Vessels, Vol. 12, No. SUPPL. 12, 01.12.1997, p. 138-141.

Research output: Contribution to journalArticle

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