Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: Comparative study of capability for management of pulmonary nodules

Yoshiharu Ohno, Hisanobu Koyama, Daisuke Takenaka, Munenobu Nogami, Yoshimasa Maniwa, Yoshihiro Nishimura, Chiho Ohbayashi, Kazuro Sugimura

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Purpose: To compare the nodule management capabilities of dynamic MRI, dynamic multidetector-row computed tomography (MDCT) and coregistered positron emission tomography (PET)/CT. Materials and Methods: Dynamic MRI, dynamic MDCT, PET, microbacterial, and pathological examinations were administered to 175 consecutive patients with 202 nodules (<30 mm in diameter). The final diagnoses resulted in the classification of 202 nodules into two groups: requiring further intervention and treatment (N = 163) and no further evaluation (N = 39) groups. Maximum relative enhancement and slope of enhancement ratio were calculated as dynamic MR indices. Maximum enhancement, net enhancement, slope of enhancement, and absolute loss of enhancement were calculated as dynamic CT indices, maximum value of standard uptake value (SUVmax) was measured on coregistered PET/CT. Receiver operating characteristics (ROC) analyses were performed to determine feasible threshold values for nodule management, and results were tested using McNemar's test. Results: When feasibility threshold values were adopted for nodule management, the specificity (82.1%) and accuracy (93.6%) of the slope of the enhancement ratio were significantly higher than those of dynamic CT indices (P < 0.05) and SUV max (P < 0.05). Conclusion: Dynamic MRI can play a more specific and/or accurate role for nodule management as compared with dynamic MDCT and coregistered PET/CT.

Original languageEnglish
Pages (from-to)1284-1295
Number of pages12
JournalJournal of Magnetic Resonance Imaging
Volume27
Issue number6
DOIs
Publication statusPublished - 06-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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