Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases

Hiroshi Matsubara, Akihiro Itoh, Hiroki Kawashima, Toshifumi Kasugai, Eizaburo Ohno, Takuya Ishikawa, Yuya Itoh, Yosuke Nakamura, Takeshi Hiramatsu, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto, Yoshiki Hirooka

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Objectives: This study aimed to investigate the usefulness of contrast-enhanced endoscopic ultrasonography (EUS) with time-intensity curve (TIC) in differentiating pancreatic diseases. Methods: Patients who underwent contrast-enhanced EUS between January 2007 and June 2009 were analyzed retrospectively, including 48 with pancreatic ductal cancer (PC), 14 with autoimmune pancreatitis (AIP), 13 with mass-forming pancreatitis (MFP), and 16 with pancreatic endocrine tumor (PET). After intravenous injection of contrast agent, contrast imaging pattern, TIC-based quantitative evaluation, and diagnostic ability of EUS in combination with TIC to diagnose benignancy or malignancy were assessed. Results: Hypovascular and heterogeneous pattern (42/48) in PC, isovascular and homogenous (21/27) in AIP and MFP, and hypervascular and rapid stained (16/16) in PET were observed. The echo intensity reduction rate from the peak at 1 minute was the greatest in PC followed by MFP, AIP, and PET (P < 0.05). The diagnostic accuracies based on contrast imaging pattern (84.0%) and TIC (88.0%) were higher than those based on B-mode imaging (82.6%) and dynamic computed tomography (81.3%). In EUS in combination with TIC, sensitivity, specificity, and accuracy rose up to 95.8%, 92.6%, and 94.7%, respectively. Conclusions: Contrast-enhanced EUS with the dynamic quantitative analysis preparing TIC increased the diagnostic accuracy for pancreatic diseases.

Original languageEnglish
Pages (from-to)1073-1079
Number of pages7
JournalPancreas
Volume40
Issue number7
DOIs
Publication statusPublished - 01-10-2011
Externally publishedYes

Fingerprint

Pancreatic Diseases
Endosonography
Pancreatitis
Pancreatic Neoplasms
Neoplasms
Intravenous Injections
Contrast Media
Tomography
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Matsubara, H., Itoh, A., Kawashima, H., Kasugai, T., Ohno, E., Ishikawa, T., ... Hirooka, Y. (2011). Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases. Pancreas, 40(7), 1073-1079. https://doi.org/10.1097/MPA.0b013e31821f57b7
Matsubara, Hiroshi ; Itoh, Akihiro ; Kawashima, Hiroki ; Kasugai, Toshifumi ; Ohno, Eizaburo ; Ishikawa, Takuya ; Itoh, Yuya ; Nakamura, Yosuke ; Hiramatsu, Takeshi ; Nakamura, Masanao ; Miyahara, Ryoji ; Ohmiya, Naoki ; Ishigami, Masatoshi ; Katano, Yoshiaki ; Goto, Hidemi ; Hirooka, Yoshiki. / Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases. In: Pancreas. 2011 ; Vol. 40, No. 7. pp. 1073-1079.
@article{2c12f7da648845969fd350366b7dc0c0,
title = "Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases",
abstract = "Objectives: This study aimed to investigate the usefulness of contrast-enhanced endoscopic ultrasonography (EUS) with time-intensity curve (TIC) in differentiating pancreatic diseases. Methods: Patients who underwent contrast-enhanced EUS between January 2007 and June 2009 were analyzed retrospectively, including 48 with pancreatic ductal cancer (PC), 14 with autoimmune pancreatitis (AIP), 13 with mass-forming pancreatitis (MFP), and 16 with pancreatic endocrine tumor (PET). After intravenous injection of contrast agent, contrast imaging pattern, TIC-based quantitative evaluation, and diagnostic ability of EUS in combination with TIC to diagnose benignancy or malignancy were assessed. Results: Hypovascular and heterogeneous pattern (42/48) in PC, isovascular and homogenous (21/27) in AIP and MFP, and hypervascular and rapid stained (16/16) in PET were observed. The echo intensity reduction rate from the peak at 1 minute was the greatest in PC followed by MFP, AIP, and PET (P < 0.05). The diagnostic accuracies based on contrast imaging pattern (84.0{\%}) and TIC (88.0{\%}) were higher than those based on B-mode imaging (82.6{\%}) and dynamic computed tomography (81.3{\%}). In EUS in combination with TIC, sensitivity, specificity, and accuracy rose up to 95.8{\%}, 92.6{\%}, and 94.7{\%}, respectively. Conclusions: Contrast-enhanced EUS with the dynamic quantitative analysis preparing TIC increased the diagnostic accuracy for pancreatic diseases.",
author = "Hiroshi Matsubara and Akihiro Itoh and Hiroki Kawashima and Toshifumi Kasugai and Eizaburo Ohno and Takuya Ishikawa and Yuya Itoh and Yosuke Nakamura and Takeshi Hiramatsu and Masanao Nakamura and Ryoji Miyahara and Naoki Ohmiya and Masatoshi Ishigami and Yoshiaki Katano and Hidemi Goto and Yoshiki Hirooka",
year = "2011",
month = "10",
day = "1",
doi = "10.1097/MPA.0b013e31821f57b7",
language = "English",
volume = "40",
pages = "1073--1079",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

Matsubara, H, Itoh, A, Kawashima, H, Kasugai, T, Ohno, E, Ishikawa, T, Itoh, Y, Nakamura, Y, Hiramatsu, T, Nakamura, M, Miyahara, R, Ohmiya, N, Ishigami, M, Katano, Y, Goto, H & Hirooka, Y 2011, 'Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases', Pancreas, vol. 40, no. 7, pp. 1073-1079. https://doi.org/10.1097/MPA.0b013e31821f57b7

Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases. / Matsubara, Hiroshi; Itoh, Akihiro; Kawashima, Hiroki; Kasugai, Toshifumi; Ohno, Eizaburo; Ishikawa, Takuya; Itoh, Yuya; Nakamura, Yosuke; Hiramatsu, Takeshi; Nakamura, Masanao; Miyahara, Ryoji; Ohmiya, Naoki; Ishigami, Masatoshi; Katano, Yoshiaki; Goto, Hidemi; Hirooka, Yoshiki.

In: Pancreas, Vol. 40, No. 7, 01.10.2011, p. 1073-1079.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases

AU - Matsubara, Hiroshi

AU - Itoh, Akihiro

AU - Kawashima, Hiroki

AU - Kasugai, Toshifumi

AU - Ohno, Eizaburo

AU - Ishikawa, Takuya

AU - Itoh, Yuya

AU - Nakamura, Yosuke

AU - Hiramatsu, Takeshi

AU - Nakamura, Masanao

AU - Miyahara, Ryoji

AU - Ohmiya, Naoki

AU - Ishigami, Masatoshi

AU - Katano, Yoshiaki

AU - Goto, Hidemi

AU - Hirooka, Yoshiki

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Objectives: This study aimed to investigate the usefulness of contrast-enhanced endoscopic ultrasonography (EUS) with time-intensity curve (TIC) in differentiating pancreatic diseases. Methods: Patients who underwent contrast-enhanced EUS between January 2007 and June 2009 were analyzed retrospectively, including 48 with pancreatic ductal cancer (PC), 14 with autoimmune pancreatitis (AIP), 13 with mass-forming pancreatitis (MFP), and 16 with pancreatic endocrine tumor (PET). After intravenous injection of contrast agent, contrast imaging pattern, TIC-based quantitative evaluation, and diagnostic ability of EUS in combination with TIC to diagnose benignancy or malignancy were assessed. Results: Hypovascular and heterogeneous pattern (42/48) in PC, isovascular and homogenous (21/27) in AIP and MFP, and hypervascular and rapid stained (16/16) in PET were observed. The echo intensity reduction rate from the peak at 1 minute was the greatest in PC followed by MFP, AIP, and PET (P < 0.05). The diagnostic accuracies based on contrast imaging pattern (84.0%) and TIC (88.0%) were higher than those based on B-mode imaging (82.6%) and dynamic computed tomography (81.3%). In EUS in combination with TIC, sensitivity, specificity, and accuracy rose up to 95.8%, 92.6%, and 94.7%, respectively. Conclusions: Contrast-enhanced EUS with the dynamic quantitative analysis preparing TIC increased the diagnostic accuracy for pancreatic diseases.

AB - Objectives: This study aimed to investigate the usefulness of contrast-enhanced endoscopic ultrasonography (EUS) with time-intensity curve (TIC) in differentiating pancreatic diseases. Methods: Patients who underwent contrast-enhanced EUS between January 2007 and June 2009 were analyzed retrospectively, including 48 with pancreatic ductal cancer (PC), 14 with autoimmune pancreatitis (AIP), 13 with mass-forming pancreatitis (MFP), and 16 with pancreatic endocrine tumor (PET). After intravenous injection of contrast agent, contrast imaging pattern, TIC-based quantitative evaluation, and diagnostic ability of EUS in combination with TIC to diagnose benignancy or malignancy were assessed. Results: Hypovascular and heterogeneous pattern (42/48) in PC, isovascular and homogenous (21/27) in AIP and MFP, and hypervascular and rapid stained (16/16) in PET were observed. The echo intensity reduction rate from the peak at 1 minute was the greatest in PC followed by MFP, AIP, and PET (P < 0.05). The diagnostic accuracies based on contrast imaging pattern (84.0%) and TIC (88.0%) were higher than those based on B-mode imaging (82.6%) and dynamic computed tomography (81.3%). In EUS in combination with TIC, sensitivity, specificity, and accuracy rose up to 95.8%, 92.6%, and 94.7%, respectively. Conclusions: Contrast-enhanced EUS with the dynamic quantitative analysis preparing TIC increased the diagnostic accuracy for pancreatic diseases.

UR - http://www.scopus.com/inward/record.url?scp=80052965860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052965860&partnerID=8YFLogxK

U2 - 10.1097/MPA.0b013e31821f57b7

DO - 10.1097/MPA.0b013e31821f57b7

M3 - Article

C2 - 21633317

AN - SCOPUS:80052965860

VL - 40

SP - 1073

EP - 1079

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 7

ER -