TY - JOUR
T1 - Dysregulated HPA axis during postnatal developmental stages in the BTBR T+ Itpr3tf/J mouse
T2 - A model of autism spectrum disorder
AU - Endo, Nozomi
AU - Hiraishi, Atsuo
AU - Goto, Sayaka
AU - Nozu, Hitoshi
AU - Mannari-Sasagawa, Takayo
AU - Horii-Hayashi, Noriko
AU - Kitsuki, Michiko
AU - Okuda, Mamiko
AU - Makinodan, Manabu
AU - Nishi, Mayumi
N1 - Publisher Copyright:
© 2024 The Author(s). Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
PY - 2024
Y1 - 2024
N2 - Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Some children with ASD show enhanced cortisol response to stress. BTBR T+ Itpr3tf/J (BTBR) mice, an ASD model, display behavior consistent with the three diagnostic categories of ASD and exhibit an exaggerated response to stress in adulthood. However, it remains unclear how basal corticosterone levels change and how the hypothalamic–pituitary–adrenal axis responds to stress during the early life stages in BTBR mice. In this study, we found that basal corticosterone levels showed characteristic changes, peaking at weaning during postnatal development in both BTBR and control C57BL/6J (B6J) mice. Furthermore, we observed higher corticosterone and corticotropin-releasing hormone levels in BTBR mice than in B6J mice following acute stress exposure during weaning; however, adrenocorticotropic hormone levels were lower in BTBR mice. Glucocorticoid receptor mRNA expression levels in the hippocampus and lateral septum after stress were higher in BTBR mice than in B6J mice. This study documented changes in corticosterone levels at baseline during postnatal development in mice and showed that BTBR mice exhibited disrupted stress responses at weaning.
AB - Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Some children with ASD show enhanced cortisol response to stress. BTBR T+ Itpr3tf/J (BTBR) mice, an ASD model, display behavior consistent with the three diagnostic categories of ASD and exhibit an exaggerated response to stress in adulthood. However, it remains unclear how basal corticosterone levels change and how the hypothalamic–pituitary–adrenal axis responds to stress during the early life stages in BTBR mice. In this study, we found that basal corticosterone levels showed characteristic changes, peaking at weaning during postnatal development in both BTBR and control C57BL/6J (B6J) mice. Furthermore, we observed higher corticosterone and corticotropin-releasing hormone levels in BTBR mice than in B6J mice following acute stress exposure during weaning; however, adrenocorticotropic hormone levels were lower in BTBR mice. Glucocorticoid receptor mRNA expression levels in the hippocampus and lateral septum after stress were higher in BTBR mice than in B6J mice. This study documented changes in corticosterone levels at baseline during postnatal development in mice and showed that BTBR mice exhibited disrupted stress responses at weaning.
KW - autism spectrum disorder
KW - early life stages
KW - endocrinology
KW - mouse model
KW - stress responses
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U2 - 10.1002/npr2.12508
DO - 10.1002/npr2.12508
M3 - Article
C2 - 39610036
AN - SCOPUS:85210474158
SN - 1340-2544
VL - 45
JO - Neuropsychopharmacology reports
JF - Neuropsychopharmacology reports
IS - 1
M1 - e12508
ER -