Early age at menarche associated with increased all-cause mortality

Koji Tamakoshi, Hiroshi Yatsuya, Akiko Tamakoshi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The objective was to examine the association between age at menarche and all-cause mortality. A population-based prospective study involving 55,128 Japanese women aged 40-79 years in 1988-1990 and followed up to December 2006 was used. A total of 6,967 deaths occurred during the follow-up. Hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, smoking and drinking status, exercise, sleeping hours, parity, menopausal status, and body mass index at baseline were calculated by Cox proportional hazards model. The HRs (95% CI) of all-cause mortality were 1.16 (1.01-1.32), 1.01 (0.92-1.11), 1.00, 0.97 (0.90-1.05), 0.98 (0.91-1.05), 0.92 (0.84-1.01), and 1.05 (0.96-1.14) for women with menarche aged 9-12, 13, 14 (referent), 15, 16, 17, 18-20 years, respectively, indicating an inverse J-shaped association (P for quadratic trend <.01). Moreover, women with menarche aged >12 years have a significantly high risk of all-cause mortality compared with those with menarche aged ≤13 years (HR 1.17, 95% CI 1.03-1.33). Comparing between women with menarche aged >13 years and ≤14 years, those with earlier age at menarche had borderline significantly high risk of all-cause mortality in both comparisons (HR 1.07, 95% CI 0.99-1.15, P = .082). Japanese women with early age at menarche of >12 years were associated with increased risk of all-cause mortality and those with late age at menarche of ≤18 years also had a slightly higher mortality risk. These associations were independent of lifestyle, anthropometric, and reproductive factors.

Original languageEnglish
Pages (from-to)771-778
Number of pages8
JournalEuropean Journal of Epidemiology
Volume26
Issue number10
DOIs
Publication statusPublished - 01-10-2011
Externally publishedYes

Fingerprint

Menarche
Mortality
Confidence Intervals
Parity
Proportional Hazards Models
Drinking
Life Style
Body Mass Index
Smoking
Prospective Studies
Exercise
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Tamakoshi, Koji ; Yatsuya, Hiroshi ; Tamakoshi, Akiko. / Early age at menarche associated with increased all-cause mortality. In: European Journal of Epidemiology. 2011 ; Vol. 26, No. 10. pp. 771-778.
@article{7e97512554194beb9194f50e00ae14bf,
title = "Early age at menarche associated with increased all-cause mortality",
abstract = "The objective was to examine the association between age at menarche and all-cause mortality. A population-based prospective study involving 55,128 Japanese women aged 40-79 years in 1988-1990 and followed up to December 2006 was used. A total of 6,967 deaths occurred during the follow-up. Hazard ratios (HR) and 95{\%} confidence intervals (CI) adjusted for age, smoking and drinking status, exercise, sleeping hours, parity, menopausal status, and body mass index at baseline were calculated by Cox proportional hazards model. The HRs (95{\%} CI) of all-cause mortality were 1.16 (1.01-1.32), 1.01 (0.92-1.11), 1.00, 0.97 (0.90-1.05), 0.98 (0.91-1.05), 0.92 (0.84-1.01), and 1.05 (0.96-1.14) for women with menarche aged 9-12, 13, 14 (referent), 15, 16, 17, 18-20 years, respectively, indicating an inverse J-shaped association (P for quadratic trend <.01). Moreover, women with menarche aged >12 years have a significantly high risk of all-cause mortality compared with those with menarche aged ≤13 years (HR 1.17, 95{\%} CI 1.03-1.33). Comparing between women with menarche aged >13 years and ≤14 years, those with earlier age at menarche had borderline significantly high risk of all-cause mortality in both comparisons (HR 1.07, 95{\%} CI 0.99-1.15, P = .082). Japanese women with early age at menarche of >12 years were associated with increased risk of all-cause mortality and those with late age at menarche of ≤18 years also had a slightly higher mortality risk. These associations were independent of lifestyle, anthropometric, and reproductive factors.",
author = "Koji Tamakoshi and Hiroshi Yatsuya and Akiko Tamakoshi",
year = "2011",
month = "10",
day = "1",
doi = "10.1007/s10654-011-9623-0",
language = "English",
volume = "26",
pages = "771--778",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer Netherlands",
number = "10",

}

Early age at menarche associated with increased all-cause mortality. / Tamakoshi, Koji; Yatsuya, Hiroshi; Tamakoshi, Akiko.

In: European Journal of Epidemiology, Vol. 26, No. 10, 01.10.2011, p. 771-778.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Early age at menarche associated with increased all-cause mortality

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Akiko

PY - 2011/10/1

Y1 - 2011/10/1

N2 - The objective was to examine the association between age at menarche and all-cause mortality. A population-based prospective study involving 55,128 Japanese women aged 40-79 years in 1988-1990 and followed up to December 2006 was used. A total of 6,967 deaths occurred during the follow-up. Hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, smoking and drinking status, exercise, sleeping hours, parity, menopausal status, and body mass index at baseline were calculated by Cox proportional hazards model. The HRs (95% CI) of all-cause mortality were 1.16 (1.01-1.32), 1.01 (0.92-1.11), 1.00, 0.97 (0.90-1.05), 0.98 (0.91-1.05), 0.92 (0.84-1.01), and 1.05 (0.96-1.14) for women with menarche aged 9-12, 13, 14 (referent), 15, 16, 17, 18-20 years, respectively, indicating an inverse J-shaped association (P for quadratic trend <.01). Moreover, women with menarche aged >12 years have a significantly high risk of all-cause mortality compared with those with menarche aged ≤13 years (HR 1.17, 95% CI 1.03-1.33). Comparing between women with menarche aged >13 years and ≤14 years, those with earlier age at menarche had borderline significantly high risk of all-cause mortality in both comparisons (HR 1.07, 95% CI 0.99-1.15, P = .082). Japanese women with early age at menarche of >12 years were associated with increased risk of all-cause mortality and those with late age at menarche of ≤18 years also had a slightly higher mortality risk. These associations were independent of lifestyle, anthropometric, and reproductive factors.

AB - The objective was to examine the association between age at menarche and all-cause mortality. A population-based prospective study involving 55,128 Japanese women aged 40-79 years in 1988-1990 and followed up to December 2006 was used. A total of 6,967 deaths occurred during the follow-up. Hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, smoking and drinking status, exercise, sleeping hours, parity, menopausal status, and body mass index at baseline were calculated by Cox proportional hazards model. The HRs (95% CI) of all-cause mortality were 1.16 (1.01-1.32), 1.01 (0.92-1.11), 1.00, 0.97 (0.90-1.05), 0.98 (0.91-1.05), 0.92 (0.84-1.01), and 1.05 (0.96-1.14) for women with menarche aged 9-12, 13, 14 (referent), 15, 16, 17, 18-20 years, respectively, indicating an inverse J-shaped association (P for quadratic trend <.01). Moreover, women with menarche aged >12 years have a significantly high risk of all-cause mortality compared with those with menarche aged ≤13 years (HR 1.17, 95% CI 1.03-1.33). Comparing between women with menarche aged >13 years and ≤14 years, those with earlier age at menarche had borderline significantly high risk of all-cause mortality in both comparisons (HR 1.07, 95% CI 0.99-1.15, P = .082). Japanese women with early age at menarche of >12 years were associated with increased risk of all-cause mortality and those with late age at menarche of ≤18 years also had a slightly higher mortality risk. These associations were independent of lifestyle, anthropometric, and reproductive factors.

UR - http://www.scopus.com/inward/record.url?scp=82655172887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82655172887&partnerID=8YFLogxK

U2 - 10.1007/s10654-011-9623-0

DO - 10.1007/s10654-011-9623-0

M3 - Article

VL - 26

SP - 771

EP - 778

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 10

ER -