Early and delayed Tc-99m ECD brain SPECT in SLE patients with CNS involvement

Kaoru Kikukawa, Hiroshi Toyama, Masao Katayama, Tetsuhiro Nishimura, Kazutaka Ejiri, Kazuyuki Minami, Kaname Matsumura, Hitomi Miyama, Yutaka Emoto, Hisato Maeda, Kohei Senda, Akira Takeuchi, Hisaji Oshima, Shunji Yoshida, Katsutaka Torikai, Sukehiko Koga

Research output: Contribution to journalArticle

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Abstract

We compared early and delayed Tc-99m ECD SPECT scans in 32 SLE patients (Group 1, definite neuropsychiatric disorders; Group 2, minor neurologic symptoms or normal) with those of normal controls by visual inspection and semi-quantitative evaluation. With visual interpretation, 13 out of 14 patients in Group 1 (93%) and 7 out of 18 patients in Group 2 (39%) had diffuse uneven decrease in early scans. Seven patients in Group 2 (39%) who had normal early scans demonstrated focal decrease in the medial frontal lobe in delayed scans. With cerebral region to cerebellar ratios, in early scans, the medial frontal lobe in Group 1 and Group 2 was significantly lower than in normal controls, and lateral frontal lobe and occipital lobes in Group 1 were significantly lower than in normal controls. Nevertheless, in delayed scans, every cortical region except for the parietal lobe in Groups 1 and 2 was significantly lower than in normal controls. The retention rates in all regions in SLE patients were significantly lower than in normal controls. No case showed SPECT improvement on follow-up studies in either group in spite of clinical improvement. Delayed Tc-99m ECD brain SPECT of high sensitivity might be useful in detecting CNS involvement. Although the SPECT findings did not correlate with the neuropsychiatric symptoms, early and delayed Tc-99m ECD SPECT seems to provide useful objective diagnostic information in SLE patients.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalAnnals of Nuclear Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 01-01-2000

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Single-Photon Emission-Computed Tomography
Brain
Frontal Lobe
Occipital Lobe
Parietal Lobe
Neurologic Manifestations
technetium Tc 99m bicisate

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kikukawa, Kaoru ; Toyama, Hiroshi ; Katayama, Masao ; Nishimura, Tetsuhiro ; Ejiri, Kazutaka ; Minami, Kazuyuki ; Matsumura, Kaname ; Miyama, Hitomi ; Emoto, Yutaka ; Maeda, Hisato ; Senda, Kohei ; Takeuchi, Akira ; Oshima, Hisaji ; Yoshida, Shunji ; Torikai, Katsutaka ; Koga, Sukehiko. / Early and delayed Tc-99m ECD brain SPECT in SLE patients with CNS involvement. In: Annals of Nuclear Medicine. 2000 ; Vol. 14, No. 1. pp. 25-32.
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abstract = "We compared early and delayed Tc-99m ECD SPECT scans in 32 SLE patients (Group 1, definite neuropsychiatric disorders; Group 2, minor neurologic symptoms or normal) with those of normal controls by visual inspection and semi-quantitative evaluation. With visual interpretation, 13 out of 14 patients in Group 1 (93{\%}) and 7 out of 18 patients in Group 2 (39{\%}) had diffuse uneven decrease in early scans. Seven patients in Group 2 (39{\%}) who had normal early scans demonstrated focal decrease in the medial frontal lobe in delayed scans. With cerebral region to cerebellar ratios, in early scans, the medial frontal lobe in Group 1 and Group 2 was significantly lower than in normal controls, and lateral frontal lobe and occipital lobes in Group 1 were significantly lower than in normal controls. Nevertheless, in delayed scans, every cortical region except for the parietal lobe in Groups 1 and 2 was significantly lower than in normal controls. The retention rates in all regions in SLE patients were significantly lower than in normal controls. No case showed SPECT improvement on follow-up studies in either group in spite of clinical improvement. Delayed Tc-99m ECD brain SPECT of high sensitivity might be useful in detecting CNS involvement. Although the SPECT findings did not correlate with the neuropsychiatric symptoms, early and delayed Tc-99m ECD SPECT seems to provide useful objective diagnostic information in SLE patients.",
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Kikukawa, K, Toyama, H, Katayama, M, Nishimura, T, Ejiri, K, Minami, K, Matsumura, K, Miyama, H, Emoto, Y, Maeda, H, Senda, K, Takeuchi, A, Oshima, H, Yoshida, S, Torikai, K & Koga, S 2000, 'Early and delayed Tc-99m ECD brain SPECT in SLE patients with CNS involvement', Annals of Nuclear Medicine, vol. 14, no. 1, pp. 25-32. https://doi.org/10.1007/BF02990475

Early and delayed Tc-99m ECD brain SPECT in SLE patients with CNS involvement. / Kikukawa, Kaoru; Toyama, Hiroshi; Katayama, Masao; Nishimura, Tetsuhiro; Ejiri, Kazutaka; Minami, Kazuyuki; Matsumura, Kaname; Miyama, Hitomi; Emoto, Yutaka; Maeda, Hisato; Senda, Kohei; Takeuchi, Akira; Oshima, Hisaji; Yoshida, Shunji; Torikai, Katsutaka; Koga, Sukehiko.

In: Annals of Nuclear Medicine, Vol. 14, No. 1, 01.01.2000, p. 25-32.

Research output: Contribution to journalArticle

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T1 - Early and delayed Tc-99m ECD brain SPECT in SLE patients with CNS involvement

AU - Kikukawa, Kaoru

AU - Toyama, Hiroshi

AU - Katayama, Masao

AU - Nishimura, Tetsuhiro

AU - Ejiri, Kazutaka

AU - Minami, Kazuyuki

AU - Matsumura, Kaname

AU - Miyama, Hitomi

AU - Emoto, Yutaka

AU - Maeda, Hisato

AU - Senda, Kohei

AU - Takeuchi, Akira

AU - Oshima, Hisaji

AU - Yoshida, Shunji

AU - Torikai, Katsutaka

AU - Koga, Sukehiko

PY - 2000/1/1

Y1 - 2000/1/1

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