TY - JOUR
T1 - Early detection and invasive passivation of future culprit lesions
T2 - A future potential or an unrealistic pursuit of chimeras?
AU - Bourantas, Christos V.
AU - Garcia-Garcia, Hector M.
AU - Diletti, Roberto
AU - Muramatsu, Takashi
AU - Serruys, Patrick W.
N1 - Funding Information:
Christos Bourantas wishes to acknowledge the funding support of the Hellenic Heart Foundation (ELIKAR), Athens, Greece. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the manuscript, and its final contents. None of the authors have any conflict of interest to declare.
PY - 2013/6
Y1 - 2013/6
N2 - New advances in image and signal processing have allowed the development of numerous invasive and noninvasive imaging modalities that have revealed details of plaque pathology and allowed us to study in vivo the atherosclerotic evolution. Recent natural history of atherosclerosis studies permitted us to evaluate changes in the compositional and morphological characteristics of the plaque and identify predictors of future events. The idea of being able to identify future culprit lesions and passivate these plaques has gradually matured, and small scale studies have provided proofs about the feasibility of this concept. This review article summarizes the recent advances in the study of atherosclerosis, cites the current evidence, highlights our limitations in understanding the evolution of the plaque and in predicting plaque destabilization, and discusses the potentiality of an early invasive sealing of future culprit lesions. (Am Heart J 2013;165:869-881.e4.).
AB - New advances in image and signal processing have allowed the development of numerous invasive and noninvasive imaging modalities that have revealed details of plaque pathology and allowed us to study in vivo the atherosclerotic evolution. Recent natural history of atherosclerosis studies permitted us to evaluate changes in the compositional and morphological characteristics of the plaque and identify predictors of future events. The idea of being able to identify future culprit lesions and passivate these plaques has gradually matured, and small scale studies have provided proofs about the feasibility of this concept. This review article summarizes the recent advances in the study of atherosclerosis, cites the current evidence, highlights our limitations in understanding the evolution of the plaque and in predicting plaque destabilization, and discusses the potentiality of an early invasive sealing of future culprit lesions. (Am Heart J 2013;165:869-881.e4.).
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U2 - 10.1016/j.ahj.2013.02.015
DO - 10.1016/j.ahj.2013.02.015
M3 - Review article
C2 - 23708157
AN - SCOPUS:84880063070
SN - 0002-8703
VL - 165
SP - 869-881.e4
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -