Early detection and invasive passivation of future culprit lesions: A future potential or an unrealistic pursuit of chimeras?

Christos V. Bourantas; Hector M. Garcia-Garcia; Roberto Diletti; Takashi Muramatsu; Patrick W. Serruys

doi:10.1016/j.ahj.2013.02.015

Early detection and invasive passivation of future culprit lesions: A future potential or an unrealistic pursuit of chimeras?

Christos V. Bourantas
, Hector M. Garcia-Garcia
, Roberto Diletti
, Takashi Muramatsu
, Patrick W. Serruys

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

New advances in image and signal processing have allowed the development of numerous invasive and noninvasive imaging modalities that have revealed details of plaque pathology and allowed us to study in vivo the atherosclerotic evolution. Recent natural history of atherosclerosis studies permitted us to evaluate changes in the compositional and morphological characteristics of the plaque and identify predictors of future events. The idea of being able to identify future culprit lesions and passivate these plaques has gradually matured, and small scale studies have provided proofs about the feasibility of this concept. This review article summarizes the recent advances in the study of atherosclerosis, cites the current evidence, highlights our limitations in understanding the evolution of the plaque and in predicting plaque destabilization, and discusses the potentiality of an early invasive sealing of future culprit lesions. (Am Heart J 2013;165:869-881.e4.).

Original language	English
Pages (from-to)	869-881.e4
Journal	American Heart Journal
Volume	165
Issue number	6
DOIs	https://doi.org/10.1016/j.ahj.2013.02.015
Publication status	Published - 06-2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.ahj.2013.02.015

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@article{b5af71b0792743ceaecd3affadbe3300,

title = "Early detection and invasive passivation of future culprit lesions: A future potential or an unrealistic pursuit of chimeras?",

abstract = "New advances in image and signal processing have allowed the development of numerous invasive and noninvasive imaging modalities that have revealed details of plaque pathology and allowed us to study in vivo the atherosclerotic evolution. Recent natural history of atherosclerosis studies permitted us to evaluate changes in the compositional and morphological characteristics of the plaque and identify predictors of future events. The idea of being able to identify future culprit lesions and passivate these plaques has gradually matured, and small scale studies have provided proofs about the feasibility of this concept. This review article summarizes the recent advances in the study of atherosclerosis, cites the current evidence, highlights our limitations in understanding the evolution of the plaque and in predicting plaque destabilization, and discusses the potentiality of an early invasive sealing of future culprit lesions. (Am Heart J 2013;165:869-881.e4.).",

author = "Bourantas, \{Christos V.\} and Garcia-Garcia, \{Hector M.\} and Roberto Diletti and Takashi Muramatsu and Serruys, \{Patrick W.\}",

note = "Funding Information: Christos Bourantas wishes to acknowledge the funding support of the Hellenic Heart Foundation (ELIKAR), Athens, Greece. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the manuscript, and its final contents. None of the authors have any conflict of interest to declare. ",

year = "2013",

month = jun,

doi = "10.1016/j.ahj.2013.02.015",

language = "English",

volume = "165",

pages = "869--881.e4",

journal = "American Heart Journal",

issn = "0002-8703",

publisher = "Elsevier Inc.",

number = "6",

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TY - JOUR

T1 - Early detection and invasive passivation of future culprit lesions

T2 - A future potential or an unrealistic pursuit of chimeras?

AU - Bourantas, Christos V.

AU - Garcia-Garcia, Hector M.

AU - Diletti, Roberto

AU - Muramatsu, Takashi

AU - Serruys, Patrick W.

N1 - Funding Information: Christos Bourantas wishes to acknowledge the funding support of the Hellenic Heart Foundation (ELIKAR), Athens, Greece. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the manuscript, and its final contents. None of the authors have any conflict of interest to declare.

PY - 2013/6

Y1 - 2013/6

N2 - New advances in image and signal processing have allowed the development of numerous invasive and noninvasive imaging modalities that have revealed details of plaque pathology and allowed us to study in vivo the atherosclerotic evolution. Recent natural history of atherosclerosis studies permitted us to evaluate changes in the compositional and morphological characteristics of the plaque and identify predictors of future events. The idea of being able to identify future culprit lesions and passivate these plaques has gradually matured, and small scale studies have provided proofs about the feasibility of this concept. This review article summarizes the recent advances in the study of atherosclerosis, cites the current evidence, highlights our limitations in understanding the evolution of the plaque and in predicting plaque destabilization, and discusses the potentiality of an early invasive sealing of future culprit lesions. (Am Heart J 2013;165:869-881.e4.).

AB - New advances in image and signal processing have allowed the development of numerous invasive and noninvasive imaging modalities that have revealed details of plaque pathology and allowed us to study in vivo the atherosclerotic evolution. Recent natural history of atherosclerosis studies permitted us to evaluate changes in the compositional and morphological characteristics of the plaque and identify predictors of future events. The idea of being able to identify future culprit lesions and passivate these plaques has gradually matured, and small scale studies have provided proofs about the feasibility of this concept. This review article summarizes the recent advances in the study of atherosclerosis, cites the current evidence, highlights our limitations in understanding the evolution of the plaque and in predicting plaque destabilization, and discusses the potentiality of an early invasive sealing of future culprit lesions. (Am Heart J 2013;165:869-881.e4.).

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DO - 10.1016/j.ahj.2013.02.015

M3 - Review article

C2 - 23708157

AN - SCOPUS:84880063070

SN - 0002-8703

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JO - American Heart Journal

JF - American Heart Journal

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ER -

Early detection and invasive passivation of future culprit lesions: A future potential or an unrealistic pursuit of chimeras?

Abstract

All Science Journal Classification (ASJC) codes

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