Early detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein

Junichi Ishii, Youichi Nagamura, Masanori Nomura, Jian Hua Wang, Shinn Taga, Masatomo Kinoshita, Hiroshi Kurokawa, Masatsugu Iwase, Takeshi Kondo, Yoshihiko Watanabe, Hitoshi Hishida, Takao Tanaka, Keishiro Kawamura

Research output: Contribution to journalArticle

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Abstract

Both human heart-type cytoplasmic fatty acid-binding protein (H-FABPc) and myoglobin are low molecular weight proteins that are abundant in the cytoplasm of myocardial cells. Unlike myoglobin, H-FABPc content in the skeletal muscle is less than in cardiac muscle. To investigate the usefulness of the serum concentration of H-FABPc in the early detection of successful coronary reperfusion, we measured serum concentrations of H-FABPc and myoglobin in 45 patients with acute myocardial infarction treated with intracoronary thrombolysis or direct percutaneous translminal coronary angioplasty. Coronary angiography was performed every 5 min for reperfusion therapy to identify the onset of reperfusion. Reperfusion, defined as a TIMI grade 2 or 3, was achieved within 60 min of the initiation of reperfusion therapy in 30 patients (the reperfused group), but was not achieved in 15 patients (the non-reperfused group). Blood samples were obtained before initiation of treatment and 15, 30 and 60 min after initiation of treatment in the non-reperfused group. In the reperfused group, samples were obtained before reperfusion and 15, 30 and 60 min after reperfusion. The K-FABPc ratio (the ratio of value after to value before the initiation of treatment or reperfusion) increased sharply after the onset of reperfusion, peaking at 41±18 min, and decreased rapidly thereafter. The predictive accuracy of an H-FABPc ratio of > 1.8 for the detection of reperfusion within 60 min of the initiation of treatment was 93% at 15 min after reperfusion, 98% at 30 min, and 100% at 60 min. Similar rates of predictive accuracy were observed fora myoglobin ratio > 2.4. The H-FABPc ratio detected successful reperfusion as early as 15 min after the onset of reperfusion and was highly accurate in detecting reperfusion within 60 min of the onset of reperfusion. The predictive accuracy of the H-FABPc ratio was similar to that of the myoglobin ratio for the early detection of successful coronary reperfusion.

Original languageEnglish
Pages (from-to)13-27
Number of pages15
JournalClinica Chimica Acta
Volume262
Issue number1-2
DOIs
Publication statusPublished - 27-06-1997

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Fatty Acid-Binding Proteins
Myocardial Reperfusion
Myoglobin
Reperfusion
Serum
Muscle
Angiography
Blood
Molecular weight
human FABP3 protein
Therapeutics
Proteins
Coronary Angiography
Angioplasty

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ishii, Junichi ; Nagamura, Youichi ; Nomura, Masanori ; Wang, Jian Hua ; Taga, Shinn ; Kinoshita, Masatomo ; Kurokawa, Hiroshi ; Iwase, Masatsugu ; Kondo, Takeshi ; Watanabe, Yoshihiko ; Hishida, Hitoshi ; Tanaka, Takao ; Kawamura, Keishiro. / Early detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein. In: Clinica Chimica Acta. 1997 ; Vol. 262, No. 1-2. pp. 13-27.
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abstract = "Both human heart-type cytoplasmic fatty acid-binding protein (H-FABPc) and myoglobin are low molecular weight proteins that are abundant in the cytoplasm of myocardial cells. Unlike myoglobin, H-FABPc content in the skeletal muscle is less than in cardiac muscle. To investigate the usefulness of the serum concentration of H-FABPc in the early detection of successful coronary reperfusion, we measured serum concentrations of H-FABPc and myoglobin in 45 patients with acute myocardial infarction treated with intracoronary thrombolysis or direct percutaneous translminal coronary angioplasty. Coronary angiography was performed every 5 min for reperfusion therapy to identify the onset of reperfusion. Reperfusion, defined as a TIMI grade 2 or 3, was achieved within 60 min of the initiation of reperfusion therapy in 30 patients (the reperfused group), but was not achieved in 15 patients (the non-reperfused group). Blood samples were obtained before initiation of treatment and 15, 30 and 60 min after initiation of treatment in the non-reperfused group. In the reperfused group, samples were obtained before reperfusion and 15, 30 and 60 min after reperfusion. The K-FABPc ratio (the ratio of value after to value before the initiation of treatment or reperfusion) increased sharply after the onset of reperfusion, peaking at 41±18 min, and decreased rapidly thereafter. The predictive accuracy of an H-FABPc ratio of > 1.8 for the detection of reperfusion within 60 min of the initiation of treatment was 93{\%} at 15 min after reperfusion, 98{\%} at 30 min, and 100{\%} at 60 min. Similar rates of predictive accuracy were observed fora myoglobin ratio > 2.4. The H-FABPc ratio detected successful reperfusion as early as 15 min after the onset of reperfusion and was highly accurate in detecting reperfusion within 60 min of the onset of reperfusion. The predictive accuracy of the H-FABPc ratio was similar to that of the myoglobin ratio for the early detection of successful coronary reperfusion.",
author = "Junichi Ishii and Youichi Nagamura and Masanori Nomura and Wang, {Jian Hua} and Shinn Taga and Masatomo Kinoshita and Hiroshi Kurokawa and Masatsugu Iwase and Takeshi Kondo and Yoshihiko Watanabe and Hitoshi Hishida and Takao Tanaka and Keishiro Kawamura",
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Ishii, J, Nagamura, Y, Nomura, M, Wang, JH, Taga, S, Kinoshita, M, Kurokawa, H, Iwase, M, Kondo, T, Watanabe, Y, Hishida, H, Tanaka, T & Kawamura, K 1997, 'Early detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein', Clinica Chimica Acta, vol. 262, no. 1-2, pp. 13-27. https://doi.org/10.1016/S0009-8981(97)06547-9

Early detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein. / Ishii, Junichi; Nagamura, Youichi; Nomura, Masanori; Wang, Jian Hua; Taga, Shinn; Kinoshita, Masatomo; Kurokawa, Hiroshi; Iwase, Masatsugu; Kondo, Takeshi; Watanabe, Yoshihiko; Hishida, Hitoshi; Tanaka, Takao; Kawamura, Keishiro.

In: Clinica Chimica Acta, Vol. 262, No. 1-2, 27.06.1997, p. 13-27.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Early detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein

AU - Ishii, Junichi

AU - Nagamura, Youichi

AU - Nomura, Masanori

AU - Wang, Jian Hua

AU - Taga, Shinn

AU - Kinoshita, Masatomo

AU - Kurokawa, Hiroshi

AU - Iwase, Masatsugu

AU - Kondo, Takeshi

AU - Watanabe, Yoshihiko

AU - Hishida, Hitoshi

AU - Tanaka, Takao

AU - Kawamura, Keishiro

PY - 1997/6/27

Y1 - 1997/6/27

N2 - Both human heart-type cytoplasmic fatty acid-binding protein (H-FABPc) and myoglobin are low molecular weight proteins that are abundant in the cytoplasm of myocardial cells. Unlike myoglobin, H-FABPc content in the skeletal muscle is less than in cardiac muscle. To investigate the usefulness of the serum concentration of H-FABPc in the early detection of successful coronary reperfusion, we measured serum concentrations of H-FABPc and myoglobin in 45 patients with acute myocardial infarction treated with intracoronary thrombolysis or direct percutaneous translminal coronary angioplasty. Coronary angiography was performed every 5 min for reperfusion therapy to identify the onset of reperfusion. Reperfusion, defined as a TIMI grade 2 or 3, was achieved within 60 min of the initiation of reperfusion therapy in 30 patients (the reperfused group), but was not achieved in 15 patients (the non-reperfused group). Blood samples were obtained before initiation of treatment and 15, 30 and 60 min after initiation of treatment in the non-reperfused group. In the reperfused group, samples were obtained before reperfusion and 15, 30 and 60 min after reperfusion. The K-FABPc ratio (the ratio of value after to value before the initiation of treatment or reperfusion) increased sharply after the onset of reperfusion, peaking at 41±18 min, and decreased rapidly thereafter. The predictive accuracy of an H-FABPc ratio of > 1.8 for the detection of reperfusion within 60 min of the initiation of treatment was 93% at 15 min after reperfusion, 98% at 30 min, and 100% at 60 min. Similar rates of predictive accuracy were observed fora myoglobin ratio > 2.4. The H-FABPc ratio detected successful reperfusion as early as 15 min after the onset of reperfusion and was highly accurate in detecting reperfusion within 60 min of the onset of reperfusion. The predictive accuracy of the H-FABPc ratio was similar to that of the myoglobin ratio for the early detection of successful coronary reperfusion.

AB - Both human heart-type cytoplasmic fatty acid-binding protein (H-FABPc) and myoglobin are low molecular weight proteins that are abundant in the cytoplasm of myocardial cells. Unlike myoglobin, H-FABPc content in the skeletal muscle is less than in cardiac muscle. To investigate the usefulness of the serum concentration of H-FABPc in the early detection of successful coronary reperfusion, we measured serum concentrations of H-FABPc and myoglobin in 45 patients with acute myocardial infarction treated with intracoronary thrombolysis or direct percutaneous translminal coronary angioplasty. Coronary angiography was performed every 5 min for reperfusion therapy to identify the onset of reperfusion. Reperfusion, defined as a TIMI grade 2 or 3, was achieved within 60 min of the initiation of reperfusion therapy in 30 patients (the reperfused group), but was not achieved in 15 patients (the non-reperfused group). Blood samples were obtained before initiation of treatment and 15, 30 and 60 min after initiation of treatment in the non-reperfused group. In the reperfused group, samples were obtained before reperfusion and 15, 30 and 60 min after reperfusion. The K-FABPc ratio (the ratio of value after to value before the initiation of treatment or reperfusion) increased sharply after the onset of reperfusion, peaking at 41±18 min, and decreased rapidly thereafter. The predictive accuracy of an H-FABPc ratio of > 1.8 for the detection of reperfusion within 60 min of the initiation of treatment was 93% at 15 min after reperfusion, 98% at 30 min, and 100% at 60 min. Similar rates of predictive accuracy were observed fora myoglobin ratio > 2.4. The H-FABPc ratio detected successful reperfusion as early as 15 min after the onset of reperfusion and was highly accurate in detecting reperfusion within 60 min of the onset of reperfusion. The predictive accuracy of the H-FABPc ratio was similar to that of the myoglobin ratio for the early detection of successful coronary reperfusion.

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JF - Clinica Chimica Acta

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