TY - JOUR
T1 - Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain
AU - Saito, Kuniaki
AU - Suyama, Kazuhiko
AU - Nishida, Keiji
AU - Sei, Yoshitatsu
AU - Basile, Anthony S.
PY - 1996/3/15
Y1 - 1996/3/15
N2 - The effects of transient global ischemia using bilateral carotid artery occlusion on regional cytokine levels in gerbil brain were investigated using enzyme-linked immunoassay techniques. Brain concentrations of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were increased during the early recirculation period (<6 h) after 10 min of ischemia, with lesser degrees of elevation following only 5 min of ischemia. TNF-α levels in the hippocampus and striatum were significantly increased as early as 1 h after recirculation, declining sharply to control levels by 12 h, then transiently increasing at 24 h. Elevated levels of IL-1β and IL-6 were not seen until 3-6 h post-occlusion. No significant increases in cytokine concentrations were observed in the cerebellum or thalamus. These results suggest that regionally selective increases in cytokines may be involved in the pathophysiological changes in hippocampus and striatum following transient cerebral ischemia.
AB - The effects of transient global ischemia using bilateral carotid artery occlusion on regional cytokine levels in gerbil brain were investigated using enzyme-linked immunoassay techniques. Brain concentrations of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were increased during the early recirculation period (<6 h) after 10 min of ischemia, with lesser degrees of elevation following only 5 min of ischemia. TNF-α levels in the hippocampus and striatum were significantly increased as early as 1 h after recirculation, declining sharply to control levels by 12 h, then transiently increasing at 24 h. Elevated levels of IL-1β and IL-6 were not seen until 3-6 h post-occlusion. No significant increases in cytokine concentrations were observed in the cerebellum or thalamus. These results suggest that regionally selective increases in cytokines may be involved in the pathophysiological changes in hippocampus and striatum following transient cerebral ischemia.
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U2 - 10.1016/S0304-3940(96)12460-5
DO - 10.1016/S0304-3940(96)12460-5
M3 - Article
C2 - 8710173
AN - SCOPUS:0029670016
SN - 0304-3940
VL - 206
SP - 149
EP - 152
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -