Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

Kuniaki Saito, Kazuhiko Suyama, Keiji Nishida, Yoshitatsu Sei, Anthony S. Basile

Research output: Contribution to journalArticle

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Abstract

The effects of transient global ischemia using bilateral carotid artery occlusion on regional cytokine levels in gerbil brain were investigated using enzyme-linked immunoassay techniques. Brain concentrations of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were increased during the early recirculation period (<6 h) after 10 min of ischemia, with lesser degrees of elevation following only 5 min of ischemia. TNF-α levels in the hippocampus and striatum were significantly increased as early as 1 h after recirculation, declining sharply to control levels by 12 h, then transiently increasing at 24 h. Elevated levels of IL-1β and IL-6 were not seen until 3-6 h post-occlusion. No significant increases in cytokine concentrations were observed in the cerebellum or thalamus. These results suggest that regionally selective increases in cytokines may be involved in the pathophysiological changes in hippocampus and striatum following transient cerebral ischemia.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalNeuroscience Letters
Volume206
Issue number2-3
DOIs
Publication statusPublished - 15-03-1996
Externally publishedYes

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Gerbillinae
Transient Ischemic Attack
Interleukin-1
Interleukin-6
Ischemia
Tumor Necrosis Factor-alpha
Cytokines
Hippocampus
Brain
Thalamus
Immunoenzyme Techniques
Carotid Arteries
Cerebellum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Saito, Kuniaki ; Suyama, Kazuhiko ; Nishida, Keiji ; Sei, Yoshitatsu ; Basile, Anthony S. / Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain. In: Neuroscience Letters. 1996 ; Vol. 206, No. 2-3. pp. 149-152.
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Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain. / Saito, Kuniaki; Suyama, Kazuhiko; Nishida, Keiji; Sei, Yoshitatsu; Basile, Anthony S.

In: Neuroscience Letters, Vol. 206, No. 2-3, 15.03.1996, p. 149-152.

Research output: Contribution to journalArticle

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