Early recurrence of active IgA nephropathy after kidney transplantation

Yasuhiro Otsuka, Asami Takeda, Keiji Horike, Daijyo Inaguma, Norihiko Goto, Yoshihiko Watarai, Kunio Morozumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

IgA nephropathy (IgAN) is recurrent after transplantation; however, its time of recurrence is unpredictable. To date, factors influencing IgAN recurrence have not been elucidated. We present a case of a 23-year-old man with end-stage renal disease (ESRD) who underwent living-related ABO-identical pre-emptive kidney transplantation (PEKT) using his 57-year-old mother as a donor. IgAN started when the patient was 19 years old, and renal biopsy revealed the usual pathological findings of IgAN. In spite of steroid therapy including steroid pulse and tonsillectomy, the patient developed nephrotic syndrome and progressed to ESRD in 4 years. Protocol biopsy on day 19 following PEKT revealed active recurrent IgAN. Nephrotic-range proteinuria and mild deterioration of kidney function developed regardless of strong immunosuppressive therapy such as steroid pulse, double filtration plasmapheresis and rituximab. We report a case of refractory IgAN that recurred 19 days after transplantation. This case is considered of value to elucidate factors leading to active IgAN recurrence.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNephrology (Carlton, Vic.)
Volume19
DOIs
Publication statusPublished - 01-06-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology

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    Otsuka, Y., Takeda, A., Horike, K., Inaguma, D., Goto, N., Watarai, Y., & Morozumi, K. (2014). Early recurrence of active IgA nephropathy after kidney transplantation. Nephrology (Carlton, Vic.), 19, 45-48. https://doi.org/10.1111/nep.12252