[EBV-associated B-cell lymphoproliferative disorder of the elderly successfully treated with autologous peripheral blood stem cell transplantation and locoregional radiotherapy].

Noriko Sugino, Chishiho Nakamura, Sumie Fujii, Yusuke Matsui, Hitomi Kaneko, Mitsumasa Watanabe, Yasuo Miura, Tomoko Wakasa, Mitsuru Tsudo

Research output: Contribution to journalArticle

Abstract

Age-related EBV-associated B-cell lymphoproliferative disorder is a highly aggressive lymphoma, and a standard therapy for this disease has not yet been established. A 58-year-old male was admitted to our hospital because of fever and lymphadenopathy across the whole body. Neck lymph node biopsy showed hemorrhagic and geographic necrosis with Hodgkin-like large cells against a background of small lymphocytes. The large cells were positive for CD30 and EBER. The patient was diagnosed as having age-related EBV-associated B-cell lymphoproliferative disorder. Although there was no response to CHOP therapy, he obtained partial response after 3 courses of DeVIC therapy. Because his lymphoma was highly aggressive and chemotherapy-resistant, he underwent autologous stem cell transplantation with a conditioning regimen including ranimustine, etoposide, cytarabine, and melphalan. After stem cell transplantation and subsequent radiotherapy to the residual lesion, the patient achieved complete remission. This is the first report of successful autologous stem cell transplantation for a patient with age-related EBV-associated B-cell lymphoproliferative disorder.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume52
Issue number3
Publication statusPublished - 01-03-2011

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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