TY - JOUR
T1 - Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents
T2 - A cross-sectional study
AU - Hara, Akinori
AU - Nguyen, Phat Minh
AU - Tsujiguchi, Hiromasa
AU - Nakamura, Masaharu
AU - Yamada, Yohei
AU - Suzuki, Keita
AU - Suzuki, Fumihiko
AU - Kasahara, Tomoko
AU - Pham, Oanh Kim
AU - Nakamura, Haruki
AU - Kambayashi, Yasuhiro
AU - Shimizu, Yukari
AU - Nguyen, Thao Thi Thu
AU - Miyagi, Sakae
AU - Kannon, Takayuki
AU - Sato, Takehiro
AU - Hosomichi, Kazuyoshi
AU - Tajima, Atsushi
AU - Nakamura, Hiroyuki
N1 - Funding Information:
We would like to thank the staff of the Health and Welfare Center of Shika town and the staff of the Department of Environmental and Preventive Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University. This study was supported by a Grant-in-Aid for Scientific Research (B) by the Ministry of Education, Culture, Sport, Science and Technology (MEXT), number 19H03882, KAKEN Grant-in-Aid for Challenging Research (Exploratory) (19K22753), and a Grant-in-Aid for Scientific Research (C) by the MEXT, number 21K11720.
Funding Information:
We would like to thank the staff of the Health and Welfare Center of Shika town and the staff of the Department of Environmental and Preventive Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University. This study was supported by a Grant‐in‐Aid for Scientific Research (B) by the Ministry of Education, Culture, Sport, Science and Technology (MEXT), number 19H03882, KAKEN Grant‐in‐Aid for Challenging Research (Exploratory) (19K22753), and a Grant‐in‐Aid for Scientific Research (C) by the MEXT, number 21K11720.
Publisher Copyright:
© 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.
PY - 2022/4
Y1 - 2022/4
N2 - Objectives: The β3-adrenergic receptor (ADRB3) gene polymorphism has been implicated in obesity. Therefore, the contribution of ADRB3 Trp64Arg polymorphism to obesity-related indicators was investigated, taking into account the lifestyle-related factors in a Japanese rural population. Methods: A total of 600 Japanese adults aged ≥40 years in a population-based cohort study were analyzed. The ADRB3 polymorphism was determined using peripheral blood samples. Associations between genotype and body mass index (BMI), waist circumference (WC), and body fat (BF) percentage were examined, adjusting for lifestyle-related factors, including daily nutrient intake. Results: The frequency of Arg64 allele carriers was 36%. There was no significant difference in BMI, WC, or BF between the groups with or without the Trp64Arg polymorphism. Multivariable logistic regression analysis showed that the Trp64Arg polymorphism was not associated with these three indicators, but lifestyle factors including physical inactivity, higher energy and sodium consumption, and less animal protein intake were significantly related to increased WC and BF percentages. Conclusions: The Trp64Arg polymorphism of ADRB3 gene did not contribute to increased BMI, WC, or BF. However, lifestyle-related factors impacted these indicators in middle-aged and older Japanese individuals living in rural areas.
AB - Objectives: The β3-adrenergic receptor (ADRB3) gene polymorphism has been implicated in obesity. Therefore, the contribution of ADRB3 Trp64Arg polymorphism to obesity-related indicators was investigated, taking into account the lifestyle-related factors in a Japanese rural population. Methods: A total of 600 Japanese adults aged ≥40 years in a population-based cohort study were analyzed. The ADRB3 polymorphism was determined using peripheral blood samples. Associations between genotype and body mass index (BMI), waist circumference (WC), and body fat (BF) percentage were examined, adjusting for lifestyle-related factors, including daily nutrient intake. Results: The frequency of Arg64 allele carriers was 36%. There was no significant difference in BMI, WC, or BF between the groups with or without the Trp64Arg polymorphism. Multivariable logistic regression analysis showed that the Trp64Arg polymorphism was not associated with these three indicators, but lifestyle factors including physical inactivity, higher energy and sodium consumption, and less animal protein intake were significantly related to increased WC and BF percentages. Conclusions: The Trp64Arg polymorphism of ADRB3 gene did not contribute to increased BMI, WC, or BF. However, lifestyle-related factors impacted these indicators in middle-aged and older Japanese individuals living in rural areas.
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U2 - 10.1002/osp4.560
DO - 10.1002/osp4.560
M3 - Article
AN - SCOPUS:85115271371
SN - 2055-2238
VL - 8
SP - 199
EP - 207
JO - Obesity Science and Practice
JF - Obesity Science and Practice
IS - 2
ER -