Abstract
Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high α-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. In the elevated plus maze task, the total number of entries into the open- and enclosed-arms was smaller and the time spent in the dark enclosed arms tended to be longer in the perilla group than the safflower group. The time required to reach a safe platform in Morris's water maze test was less in the perilla group, but no significant difference was observed in the entries into the arms darkened with a movable cover in Y-maze dark-preference task. The safflower group was more sensitive to pentobarbital; the anesthesia onset time was less and the anesthetic time was longer than in the perilla group. Increased locomotion induced by scopolamine injection was less in the safflower group as compared with the perilla group. These results indicate that in mice the dietary α- linolenate/linoleate balance affects the n-3/n-6 ratio of brain phospholipid acyl chains and that this is accompanied by general behavioral changes as well as changes in sensitivities to drugs known to affect behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 239-247 |
| Number of pages | 9 |
| Journal | Journal of Lipid Research |
| Volume | 34 |
| Issue number | 2 |
| Publication status | Published - 01-01-1993 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Endocrinology
- Cell Biology
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Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice. / Nakashima, Y.; Yuasa, S.; Hukamizu, Y.; Okuyama, H.; Ohhara, T.; Kameyama, T.; Nabeshima, T.
In: Journal of Lipid Research, Vol. 34, No. 2, 01.01.1993, p. 239-247.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice
AU - Nakashima, Y.
AU - Yuasa, S.
AU - Hukamizu, Y.
AU - Okuyama, H.
AU - Ohhara, T.
AU - Kameyama, T.
AU - Nabeshima, T.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high α-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. In the elevated plus maze task, the total number of entries into the open- and enclosed-arms was smaller and the time spent in the dark enclosed arms tended to be longer in the perilla group than the safflower group. The time required to reach a safe platform in Morris's water maze test was less in the perilla group, but no significant difference was observed in the entries into the arms darkened with a movable cover in Y-maze dark-preference task. The safflower group was more sensitive to pentobarbital; the anesthesia onset time was less and the anesthetic time was longer than in the perilla group. Increased locomotion induced by scopolamine injection was less in the safflower group as compared with the perilla group. These results indicate that in mice the dietary α- linolenate/linoleate balance affects the n-3/n-6 ratio of brain phospholipid acyl chains and that this is accompanied by general behavioral changes as well as changes in sensitivities to drugs known to affect behavior.
AB - Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high α-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. In the elevated plus maze task, the total number of entries into the open- and enclosed-arms was smaller and the time spent in the dark enclosed arms tended to be longer in the perilla group than the safflower group. The time required to reach a safe platform in Morris's water maze test was less in the perilla group, but no significant difference was observed in the entries into the arms darkened with a movable cover in Y-maze dark-preference task. The safflower group was more sensitive to pentobarbital; the anesthesia onset time was less and the anesthetic time was longer than in the perilla group. Increased locomotion induced by scopolamine injection was less in the safflower group as compared with the perilla group. These results indicate that in mice the dietary α- linolenate/linoleate balance affects the n-3/n-6 ratio of brain phospholipid acyl chains and that this is accompanied by general behavioral changes as well as changes in sensitivities to drugs known to affect behavior.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027531669&partnerID=8YFLogxK
M3 - Article
C2 - 8094090
AN - SCOPUS:0027531669
VL - 34
SP - 239
EP - 247
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 2
ER -