Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice

Y. Nakashima, S. Yuasa, Y. Hukamizu, H. Okuyama, T. Ohhara, T. Kameyama, T. Nabeshima

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high α-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. In the elevated plus maze task, the total number of entries into the open- and enclosed-arms was smaller and the time spent in the dark enclosed arms tended to be longer in the perilla group than the safflower group. The time required to reach a safe platform in Morris's water maze test was less in the perilla group, but no significant difference was observed in the entries into the arms darkened with a movable cover in Y-maze dark-preference task. The safflower group was more sensitive to pentobarbital; the anesthesia onset time was less and the anesthetic time was longer than in the perilla group. Increased locomotion induced by scopolamine injection was less in the safflower group as compared with the perilla group. These results indicate that in mice the dietary α- linolenate/linoleate balance affects the n-3/n-6 ratio of brain phospholipid acyl chains and that this is accompanied by general behavioral changes as well as changes in sensitivities to drugs known to affect behavior.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalJournal of Lipid Research
Volume34
Issue number2
Publication statusPublished - 01-01-1993
Externally publishedYes

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Perilla
alpha-Linolenic Acid
Carthamus tinctorius
Linoleic Acid
Nutrition
Phospholipids
Diet
Pharmaceutical Preparations
Brain
Safflower Oil
Scopolamine Hydrobromide
Pentobarbital
Locomotion
Unsaturated Fatty Acids
Anesthetics
Anesthesia
Cholesterol
Injections
Water
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Nakashima, Y., Yuasa, S., Hukamizu, Y., Okuyama, H., Ohhara, T., Kameyama, T., & Nabeshima, T. (1993). Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice. Journal of Lipid Research, 34(2), 239-247.
Nakashima, Y. ; Yuasa, S. ; Hukamizu, Y. ; Okuyama, H. ; Ohhara, T. ; Kameyama, T. ; Nabeshima, T. / Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice. In: Journal of Lipid Research. 1993 ; Vol. 34, No. 2. pp. 239-247.
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Nakashima, Y, Yuasa, S, Hukamizu, Y, Okuyama, H, Ohhara, T, Kameyama, T & Nabeshima, T 1993, 'Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice', Journal of Lipid Research, vol. 34, no. 2, pp. 239-247.

Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice. / Nakashima, Y.; Yuasa, S.; Hukamizu, Y.; Okuyama, H.; Ohhara, T.; Kameyama, T.; Nabeshima, T.

In: Journal of Lipid Research, Vol. 34, No. 2, 01.01.1993, p. 239-247.

Research output: Contribution to journalArticle

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T1 - Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice

AU - Nakashima, Y.

AU - Yuasa, S.

AU - Hukamizu, Y.

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AU - Ohhara, T.

AU - Kameyama, T.

AU - Nabeshima, T.

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N2 - Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high α-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. In the elevated plus maze task, the total number of entries into the open- and enclosed-arms was smaller and the time spent in the dark enclosed arms tended to be longer in the perilla group than the safflower group. The time required to reach a safe platform in Morris's water maze test was less in the perilla group, but no significant difference was observed in the entries into the arms darkened with a movable cover in Y-maze dark-preference task. The safflower group was more sensitive to pentobarbital; the anesthesia onset time was less and the anesthetic time was longer than in the perilla group. Increased locomotion induced by scopolamine injection was less in the safflower group as compared with the perilla group. These results indicate that in mice the dietary α- linolenate/linoleate balance affects the n-3/n-6 ratio of brain phospholipid acyl chains and that this is accompanied by general behavioral changes as well as changes in sensitivities to drugs known to affect behavior.

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Nakashima Y, Yuasa S, Hukamizu Y, Okuyama H, Ohhara T, Kameyama T et al. Effect of a high linoleate and a high α-linolenate diet on general behavior and drug sensitivity in mice. Journal of Lipid Research. 1993 Jan 1;34(2):239-247.