Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

Takeo Yoshikawa; Chiyoko Kunishima; Kazuo Yamada; Toshitaka Nabeshima; Haruo Shibuya; Michio Toru

doi:10.1016/0196-9781(94)90208-9

Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

Takeo Yoshikawa, Chiyoko Kunishima, Kazuo Yamada, Toshitaka Nabeshima, Haruo Shibuya, Michio Toru

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

Original language	English
Pages (from-to)	471-473
Number of pages	3
Journal	Peptides
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(94)90208-9
Publication status	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(94)90208-9

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abstract = "The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.",

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AU - Yoshikawa, Takeo

AU - Kunishima, Chiyoko

AU - Yamada, Kazuo

AU - Nabeshima, Toshitaka

AU - Shibuya, Haruo

AU - Toru, Michio

PY - 1994

Y1 - 1994

N2 - The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

AB - The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

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JO - Peptides

JF - Peptides

SN - 0196-9781

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ER -

Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

Abstract

All Science Journal Classification (ASJC) codes

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