Abstract
The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.
| Original language | English |
|---|---|
| Pages (from-to) | 471-473 |
| Number of pages | 3 |
| Journal | Peptides |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1994 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience
Cite this
}
Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain. / Yoshikawa, Takeo; Kunishima, Chiyoko; Yamada, Kazuo; Nabeshima, Toshitaka; Shibuya, Haruo; Toru, Michio.
In: Peptides, Vol. 15, No. 3, 01.01.1994, p. 471-473.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain
AU - Yoshikawa, Takeo
AU - Kunishima, Chiyoko
AU - Yamada, Kazuo
AU - Nabeshima, Toshitaka
AU - Shibuya, Haruo
AU - Toru, Michio
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.
AB - The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.
UR - http://www.scopus.com/inward/record.url?scp=0028238158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028238158&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(94)90208-9
DO - 10.1016/0196-9781(94)90208-9
M3 - Article
VL - 15
SP - 471
EP - 473
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 3
ER -