Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

Takeo Yoshikawa, Chiyoko Kunishima, Kazuo Yamada, Toshitaka Nabeshima, Haruo Shibuya, Michio Toru

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

Original languageEnglish
Pages (from-to)471-473
Number of pages3
Issue number3
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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