TY - JOUR
T1 - Effect of AD-5423 on animal models of schizophrenia
T2 - Phencyclidine-induced behavioral changes in mice
AU - Nagai, T.
AU - Noda, Y.
AU - Une, T.
AU - Furukawa, K.
AU - Furukawa, H.
AU - Kan, Q. M.
AU - Nabeshima, T.
PY - 2003/2/10
Y1 - 2003/2/10
N2 - The antipsychotic efficacy of AD-5423, which has the properties of both a serotonin 5-HT2 and a dopamine D2 receptor antagonist, was evaluated using animal models of schizophrenia. Sensitization to phencyclidine (PCP)-induced hyperlocomotion is considered a model of the positive symptoms of schizophrenia, and was significantly antagonized by AD-5423 and haloperidol. The PCP-induced enhancement of immobility induced by the forced swimming test, a model of the negative symptoms of schizophrenia, was attenuated by AD-5423 but not by haloperidol. Since this attenuated effect of AD-5423 was antagonized by DOI, a serotonin 5-HT2 receptor agonist, it is postulated to be mediated by serotonin 5-HT2 receptors. These findings suggest that AD-5423 would be clinically effective against both the positive and negative symptoms of schizophrenia.
AB - The antipsychotic efficacy of AD-5423, which has the properties of both a serotonin 5-HT2 and a dopamine D2 receptor antagonist, was evaluated using animal models of schizophrenia. Sensitization to phencyclidine (PCP)-induced hyperlocomotion is considered a model of the positive symptoms of schizophrenia, and was significantly antagonized by AD-5423 and haloperidol. The PCP-induced enhancement of immobility induced by the forced swimming test, a model of the negative symptoms of schizophrenia, was attenuated by AD-5423 but not by haloperidol. Since this attenuated effect of AD-5423 was antagonized by DOI, a serotonin 5-HT2 receptor agonist, it is postulated to be mediated by serotonin 5-HT2 receptors. These findings suggest that AD-5423 would be clinically effective against both the positive and negative symptoms of schizophrenia.
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U2 - 10.1097/00001756-200302100-00023
DO - 10.1097/00001756-200302100-00023
M3 - Article
C2 - 12598744
AN - SCOPUS:0037428772
SN - 0959-4965
VL - 14
SP - 269
EP - 272
JO - Neuroreport
JF - Neuroreport
IS - 2
ER -